High PEEP/low FiO<inf>2</inf> ventilation is associated with lower mortality in COVID–19
Issued Date
2024-10-01
Resource Type
ISSN
08839441
eISSN
15578615
Scopus ID
2-s2.0-85198266818
Journal Title
Journal of Critical Care
Volume
83
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Critical Care Vol.83 (2024)
Suggested Citation
Goossen R.L., van Vliet R., Bos L.D.J., Buiteman-Kruizinga L.A., Hollman M.W., Myatra S.N., Neto A.S., Spronk P.E., van der Woude M.C.E., van Meenen D.M.P., Paulus F., Schultz M.J., Ahuja S., Algera A.G., Algoe C.K., van Amstel R.B., Artigas A., Aydeniz E., van den Berg A.E., van de Berg P., Bergmans D.C.J.J., van den Bersselaar D.I., Bertens F.A., Bevers M., Bindels A.J.G.H., Breel J.S., de Bruin S., Bruna C.L., de Boer M., den Boer S., Boers L.S., Bogerd M.B., Bos L.D.J., Bosman B., Botta M., de Bie A.J.R., Baur O.L., Buiteman-Kruizinga L.A., Coene W., Cremer O.L., Daenen K., Delmte M., Determann R.M., Dieperink W., Di Leo V., van Dijk J., Dongelmans D.A., Dormans T., Endeman H., Elting L.M., Esmeijer A.A., Franke H.S., Galek-aldridge M.S., Gama de Abreu M.G., Girbes A.R., Go D.M., Goossen R.L., de Graaff M.J., Hagens L.A., Hansen H.J., Haringman J.J., van der Heide S.T., van der Heiden P.L.J., Heijnen N.F.L., Hiel S.J.P., Hoeijmakers L.L., Hol L., Hollmann M.W., Hoogendoorn M.E., Horn J., van der Horst R., Huijben J.A., Ie E.L.K., van Ingen L.E., Ivanov D.P., Juffermans N.P., Kranen H.T., Kho E., de Klerk E.S., Koek N., Koopman-van Gemert A.W.M.M., Koopmans M., Kucukcelebi S., Kuiper M.A., Kuipers L.J., Koornstra E., Lokhorst A., de Lange D.W., Martin-Loeches I., van Meenen D.M.P., Mazzinari G., Moeniralam H., van Mourik N., Myatra S.N., Nijbroek S.G., van Oosten P., Offermans M., Onrust M., Oostdijk E.A.N., Paulus F. High PEEP/low FiO<inf>2</inf> ventilation is associated with lower mortality in COVID–19. Journal of Critical Care Vol.83 (2024). doi:10.1016/j.jcrc.2024.154854 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/99746
Title
High PEEP/low FiO<inf>2</inf> ventilation is associated with lower mortality in COVID–19
Author(s)
Goossen R.L.
van Vliet R.
Bos L.D.J.
Buiteman-Kruizinga L.A.
Hollman M.W.
Myatra S.N.
Neto A.S.
Spronk P.E.
van der Woude M.C.E.
van Meenen D.M.P.
Paulus F.
Schultz M.J.
Ahuja S.
Algera A.G.
Algoe C.K.
van Amstel R.B.
Artigas A.
Aydeniz E.
van den Berg A.E.
van de Berg P.
Bergmans D.C.J.J.
van den Bersselaar D.I.
Bertens F.A.
Bevers M.
Bindels A.J.G.H.
Breel J.S.
de Bruin S.
Bruna C.L.
de Boer M.
den Boer S.
Boers L.S.
Bogerd M.B.
Bos L.D.J.
Bosman B.
Botta M.
de Bie A.J.R.
Baur O.L.
Buiteman-Kruizinga L.A.
Coene W.
Cremer O.L.
Daenen K.
Delmte M.
Determann R.M.
Dieperink W.
Di Leo V.
van Dijk J.
Dongelmans D.A.
Dormans T.
Endeman H.
Elting L.M.
Esmeijer A.A.
Franke H.S.
Galek-aldridge M.S.
Gama de Abreu M.G.
Girbes A.R.
Go D.M.
Goossen R.L.
de Graaff M.J.
Hagens L.A.
Hansen H.J.
Haringman J.J.
van der Heide S.T.
van der Heiden P.L.J.
Heijnen N.F.L.
Hiel S.J.P.
Hoeijmakers L.L.
Hol L.
Hollmann M.W.
Hoogendoorn M.E.
Horn J.
van der Horst R.
Huijben J.A.
Ie E.L.K.
van Ingen L.E.
Ivanov D.P.
Juffermans N.P.
Kranen H.T.
Kho E.
de Klerk E.S.
Koek N.
Koopman-van Gemert A.W.M.M.
Koopmans M.
Kucukcelebi S.
Kuiper M.A.
Kuipers L.J.
Koornstra E.
Lokhorst A.
de Lange D.W.
Martin-Loeches I.
van Meenen D.M.P.
Mazzinari G.
Moeniralam H.
van Mourik N.
Myatra S.N.
Nijbroek S.G.
van Oosten P.
Offermans M.
Onrust M.
Oostdijk E.A.N.
Paulus F.
van Vliet R.
Bos L.D.J.
Buiteman-Kruizinga L.A.
Hollman M.W.
Myatra S.N.
Neto A.S.
Spronk P.E.
van der Woude M.C.E.
van Meenen D.M.P.
Paulus F.
Schultz M.J.
Ahuja S.
Algera A.G.
Algoe C.K.
van Amstel R.B.
Artigas A.
Aydeniz E.
van den Berg A.E.
van de Berg P.
Bergmans D.C.J.J.
van den Bersselaar D.I.
Bertens F.A.
Bevers M.
Bindels A.J.G.H.
Breel J.S.
de Bruin S.
Bruna C.L.
de Boer M.
den Boer S.
Boers L.S.
Bogerd M.B.
Bos L.D.J.
Bosman B.
Botta M.
de Bie A.J.R.
Baur O.L.
Buiteman-Kruizinga L.A.
Coene W.
Cremer O.L.
Daenen K.
Delmte M.
Determann R.M.
Dieperink W.
Di Leo V.
van Dijk J.
Dongelmans D.A.
Dormans T.
Endeman H.
Elting L.M.
Esmeijer A.A.
Franke H.S.
Galek-aldridge M.S.
Gama de Abreu M.G.
Girbes A.R.
Go D.M.
Goossen R.L.
de Graaff M.J.
Hagens L.A.
Hansen H.J.
Haringman J.J.
van der Heide S.T.
van der Heiden P.L.J.
Heijnen N.F.L.
Hiel S.J.P.
Hoeijmakers L.L.
Hol L.
Hollmann M.W.
Hoogendoorn M.E.
Horn J.
van der Horst R.
Huijben J.A.
Ie E.L.K.
van Ingen L.E.
Ivanov D.P.
Juffermans N.P.
Kranen H.T.
Kho E.
de Klerk E.S.
Koek N.
Koopman-van Gemert A.W.M.M.
Koopmans M.
Kucukcelebi S.
Kuiper M.A.
Kuipers L.J.
Koornstra E.
Lokhorst A.
de Lange D.W.
Martin-Loeches I.
van Meenen D.M.P.
Mazzinari G.
Moeniralam H.
van Mourik N.
Myatra S.N.
Nijbroek S.G.
van Oosten P.
Offermans M.
Onrust M.
Oostdijk E.A.N.
Paulus F.
Author's Affiliation
Mahidol Oxford Tropical Medicine Research Unit
Gelre Ziekenhuizen
University of Melbourne
Monash University
Tata Memorial Hospital
Hospital Israelita Albert Einstein
Faculty of Medicine, Nursing and Health Sciences
Medizinische Universität Wien
Nuffield Department of Medicine
Amsterdam UMC - University of Amsterdam
Reinier de Graaf Hospital - SSDZ
Heerlen Medical Center
University of Applied Science
Gelre Ziekenhuizen
University of Melbourne
Monash University
Tata Memorial Hospital
Hospital Israelita Albert Einstein
Faculty of Medicine, Nursing and Health Sciences
Medizinische Universität Wien
Nuffield Department of Medicine
Amsterdam UMC - University of Amsterdam
Reinier de Graaf Hospital - SSDZ
Heerlen Medical Center
University of Applied Science
Corresponding Author(s)
Other Contributor(s)
Abstract
Rationale: The positive end–expiratory pressure (PEEP) strategy in patients with coronavirus 2019 (COVID–19) acute respiratory distress syndrome (ARDS) remains debated. Most studies originate from the initial waves of the pandemic. Here we aimed to assess the impact of high PEEP/low FiO2 ventilation on outcomes during the second wave in the Netherlands. Methods: Retrospective observational study of invasively ventilated COVID–19 patients during the second wave. Patients were categorized based on whether they received high PEEP or low PEEP ventilation according to the ARDS Network tables. The primary outcome was ICU mortality, and secondary outcomes included hospital and 90–day mortality, duration of ventilation and length of stay, and the occurrence of kidney injury. Propensity matching was performed to correct for factors with a known relationship to ICU mortality. Results: This analysis included 790 COVID–ARDS patients. At ICU discharge, 32 (22.5%) out of 142 high PEEP patients and 254 (39.2%) out of 848 low PEEP patients had died (HR 0.66 [0.46–0.96]; P = 0.03). High PEEP was linked to improved secondary outcomes. Matched analysis did not change findings. Conclusions: High PEEP ventilation was associated with improved ICU survival in patients with COVID–ARDS.