Eosinophil-derived neurotoxin levels can predict allergic disease development and atopic march in children
Issued Date
2025-06-01
Resource Type
eISSN
27134148
Scopus ID
2-s2.0-105007646251
Journal Title
Clinical and Experimental Pediatrics
Volume
68
Issue
6
Start Page
398
End Page
405
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical and Experimental Pediatrics Vol.68 No.6 (2025) , 398-405
Suggested Citation
Callaway Z., Kim C.K. Eosinophil-derived neurotoxin levels can predict allergic disease development and atopic march in children. Clinical and Experimental Pediatrics Vol.68 No.6 (2025) , 398-405. 405. doi:10.3345/cep.2024.01382 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/110734
Title
Eosinophil-derived neurotoxin levels can predict allergic disease development and atopic march in children
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Author's Affiliation
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Abstract
In some children, atopic manifestations begin with atopic dermatitis and progress to allergic asthma and allergic rhinitis; of them, a small subset experience food allergies as well. This progression shares genetic and environmental predisposing factors and immunological features, such as allergen-specific T-helper type 2 responses, that manifest as specific immunoglobulin E production and eosinophil activation. Eosinophil-derived neurotoxin (EDN), which is released by eosinophils during this activation, shows promise as a reliable and accurate biomarker. EDN levels are elevated in a subset of patients with atopic march-associated conditions. Elevated EDN levels predict allergic disease development, demonstrating that EDN is a good biomarker for the prognosis, diagnosis, treatment, and monitoring of allergic diseases comprising atopic march. The early measurement of EDN would help identify those who are more likely to develop allergic diseases later in life. Thus, the early detection and treatment of elevated EDN could lead to better outcomes, including halting atopic march.