Virulence Characteristics and Emerging Therapies for Biofilm-Forming Acinetobacter baumannii: A Review
Issued Date
2022-09-01
Resource Type
eISSN
20797737
Scopus ID
2-s2.0-85138738071
Journal Title
Biology
Volume
11
Issue
9
Rights Holder(s)
SCOPUS
Bibliographic Citation
Biology Vol.11 No.9 (2022)
Suggested Citation
Dolma K.G., Khati R., Paul A.K., Rahmatullah M., de Lourdes Pereira M., Wilairatana P., Khandelwal B., Gupta C., Gautam D., Gupta M., Goyal R.K., Wiart C., Nissapatorn V. Virulence Characteristics and Emerging Therapies for Biofilm-Forming Acinetobacter baumannii: A Review. Biology Vol.11 No.9 (2022). doi:10.3390/biology11091343 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/84909
Title
Virulence Characteristics and Emerging Therapies for Biofilm-Forming Acinetobacter baumannii: A Review
Author's Affiliation
Faculty of Tropical Medicine, Mahidol University
Sikkim Manipal Institute of Medical Sciences
Walailak University
Universidade de Aveiro
Universiti Malaysia Sabah
University of Tasmania
CICECO – Instituto de Materiais de Aveiro
University of Development Alternative
Delhi Pharmaceutical Sciences and Research University
Sikkim Manipal Institute of Medical Sciences
Walailak University
Universidade de Aveiro
Universiti Malaysia Sabah
University of Tasmania
CICECO – Instituto de Materiais de Aveiro
University of Development Alternative
Delhi Pharmaceutical Sciences and Research University
Other Contributor(s)
Abstract
Acinetobacter species is one of the most prevailing nosocomial pathogens with a potent ability to develop antimicrobial resistance. It commonly causes infections where there is a prolonged utilization of medical devices such as CSF shunts, catheters, endotracheal tubes, and similar. There are several strains of Acinetobacter (A) species (spp), among which the majority are pathogenic to humans, but A. baumannii are entirely resistant to several clinically available antibiotics. The crucial mechanism that renders them a multidrug-resistant strain is their potent ability to synthesize biofilms. Biofilms provide ample opportunity for the microorganisms to withstand the harsh environment and further cause chronic infections. Several studies have enumerated multiple physiological and virulence factors responsible for the production and maintenance of biofilms. To further enhance our understanding of this pathogen, in this review, we discuss its taxonomy, pathogenesis, current treatment options, global resistance rates, mechanisms of its resistance against various groups of antimicrobials, and future therapeutics.