Stable isotope ratio analysis: an emerging tool to trace the origin of falsified medicines
Issued Date
2024-05-01
Resource Type
ISSN
01659936
eISSN
18793142
Scopus ID
2-s2.0-85190537399
Journal Title
TrAC - Trends in Analytical Chemistry
Volume
174
Rights Holder(s)
SCOPUS
Bibliographic Citation
TrAC - Trends in Analytical Chemistry Vol.174 (2024)
Suggested Citation
Roncone A., Kelly S.D., Giannioti Z., Hauk C., Caillet C., Newton P.N., Perez-Mon C., Bontempo L. Stable isotope ratio analysis: an emerging tool to trace the origin of falsified medicines. TrAC - Trends in Analytical Chemistry Vol.174 (2024). doi:10.1016/j.trac.2024.117666 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/98069
Title
Stable isotope ratio analysis: an emerging tool to trace the origin of falsified medicines
Corresponding Author(s)
Other Contributor(s)
Abstract
Falsified medicines pose a serious threat to global public health. Over the past few decades, the number of public health issues and seizures of falsified medicines has dramatically increased across the world. The development of new analytical techniques for the identification and traceability of these products hold great promise for innovation to help curtail the high number of deaths caused by the lack of adequate treatments and in combating the criminals responsible for manufacturing these products. This review presents the main approaches, based on stable isotope ratios of the bio-elements, mainly Isotope Ratio Mass Spectrometry and Site-specific Natural Isotopic Fractionation by Nuclear Magnetic Resonance, that can contribute to identifying the origin of these products, both in terms of geographical origin and raw materials employed as well as for the batch controls by the producers.