Effects of Phycocyanin on Oxidative Stress in The Brain of Prolonged Strenuous Exercise Rats
3
Issued Date
2025-07-01
Resource Type
eISSN
27740226
Scopus ID
2-s2.0-105010622425
Journal Title
Trends in Sciences
Volume
22
Issue
7
Rights Holder(s)
SCOPUS
Bibliographic Citation
Trends in Sciences Vol.22 No.7 (2025)
Suggested Citation
Khongsombat O., Kamsaen F., Buapheng N., Choemsuwan P., Klinprathap K., Tunsophon S. Effects of Phycocyanin on Oxidative Stress in The Brain of Prolonged Strenuous Exercise Rats. Trends in Sciences Vol.22 No.7 (2025). doi:10.48048/tis.2025.9967 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/111332
Title
Effects of Phycocyanin on Oxidative Stress in The Brain of Prolonged Strenuous Exercise Rats
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Abstract
Excessive exercise can lead to oxidative stress which can negatively affect the nervous system. Phycocyanin, a pigment in blue-green algae like spirulina, has potent antioxidant properties that help neutralize free radicals and reduce oxidative stress. This study examined the effects of phycocyanin on oxidative stress in the rat brain induced by prolonged strenuous exercise. The male Sprague-Dawley rats were divided into 5 groups: Control group, exercise group, exercise with low (100 mg/kg BW) or high (200 mg/kg BW) doses of phycocyanin or vitamin C (200 mg/kg BW). After the 8<sup>th</sup> week of experiment, brain tissue was collected to analyze malondialdehyde levels (MDA) and antioxidant activity in the prefrontal cortex, hippocampus, and amygdala. The results show that excessive exercise tends to increase MDA levels and decrease superoxide dismutase (SOD) levels, although these changes are not statistically significant. However, excessive exercise significantly reduces the antioxidant enzymes catalase (CAT) and glutathione peroxidase (GPx), which may contribute to oxidative stress. Phycocyanin, on the other hand, enhances the antioxidant activity of SOD and CAT, both of which play a critical role in mitigating oxidative damage. Interestingly, phycocyanin does not appear to significantly affect GPx levels. This suggests that phycocyanin may selectively target specific antioxidant pathways while leaving others unaffected.