Cost-effective analysis of hepatitis A vaccination in Kerala state, India
Issued Date
2024-01-01
Resource Type
eISSN
19326203
Scopus ID
2-s2.0-85197185055
Pubmed ID
38935781
Journal Title
PloS one
Volume
19
Issue
6
Rights Holder(s)
SCOPUS
Bibliographic Citation
PloS one Vol.19 No.6 (2024) , e0306293
Suggested Citation
Gurav Y.K., Bagepally B.S., Chitpim N., Sobhonslidsuk A., Gupte M.D., Chaikledkaew U., Thakkinstian A., Thavorncharoensap M. Cost-effective analysis of hepatitis A vaccination in Kerala state, India. PloS one Vol.19 No.6 (2024) , e0306293. doi:10.1371/journal.pone.0306293 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/99514
Title
Cost-effective analysis of hepatitis A vaccination in Kerala state, India
Corresponding Author(s)
Other Contributor(s)
Abstract
Several hepatitis A outbreaks have recently been reported in Kerala state, India. To inform coverage decision of hepatitis A vaccine in Kerala, this study aimed to examine the cost-effectiveness of 1) hepatitis A vaccination among children aged 1 year and individuals aged 15 years, and 2) serological screening of individuals aged 15 years and vaccination of susceptible as compared to no vaccination or vaccination without serological screening. Both live attenuated hepatitis A vaccine and inactivated hepatitis A vaccine were considered in the analysis. A combination of decision tree and Markov models with a cycle length of one year was employed to estimate costs and benefits of different vaccination strategies. Analysis were based on both societal and payer perspectives. The lifetime costs and outcomes were discounted by 3%. Our findings indicated that all strategies were cost-saving for both societal and payer perspectives. Moreover, budget impact analysis revealed that vaccination without screening among individuals aged 15 years could save the government's budget by reducing treatment cost of hepatitis A. Our cost-effectiveness evidence supports the inclusion of hepatitis A vaccination into the vaccination program for children aged 1 year and individuals aged 15 years in Kerala state, India.