Stability and biological activity enhancement of fucoxanthin through encapsulation in alginate/chitosan nanoparticles
Issued Date
2024-04-01
Resource Type
ISSN
01418130
eISSN
18790003
Scopus ID
2-s2.0-85185886261
Pubmed ID
38368987
Journal Title
International Journal of Biological Macromolecules
Volume
263
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Biological Macromolecules Vol.263 (2024)
Suggested Citation
Sorasitthiyanukarn F.N., Muangnoi C., Rojsitthisak P., Rojsitthisak P. Stability and biological activity enhancement of fucoxanthin through encapsulation in alginate/chitosan nanoparticles. International Journal of Biological Macromolecules Vol.263 (2024). doi:10.1016/j.ijbiomac.2024.130264 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/97443
Title
Stability and biological activity enhancement of fucoxanthin through encapsulation in alginate/chitosan nanoparticles
Corresponding Author(s)
Other Contributor(s)
Abstract
A response surface methodology based on the Box-Behnken design was employed to develop fucoxanthin (FX) delivery nanocarrier from alginate (ALG) and chitosan (CS). The FX-loaded ALG/CS nanoparticles (FX-ALG/CS-NPs) were fabricated using oil-in-water emulsification and ionic gelation. The optimal formulation consisted of an ALG:CS mass ratio of 0.015:1, 0.71 % w/v Tween™ 80, and 5 mg/mL FX concentrations. The resulting FX-ALG/CS-NPs had a size of 227 ± 23 nm, a zeta potential of 35.3 ± 1.7 mV, and an encapsulation efficiency of 81.2 ± 2.8 %. These nanoparticles exhibited enhanced stability under simulated environmental conditions and controlled FX release in simulated gastrointestinal fluids. Furthermore, FX-ALG/CS-NPs showed increased in vitro oral bioaccessibility, gastrointestinal stability, antioxidant activity, anti-inflammatory effect, and cytotoxicity against various cancer cells. The findings suggest that ALG/CS-NPs are effective nanocarriers for the delivery of FX in nutraceuticals, functional foods, and pharmaceuticals.