Asian diversity in human immune cells
1
Issued Date
2025-01-01
Resource Type
ISSN
00928674
eISSN
10974172
Scopus ID
2-s2.0-105000483474
Journal Title
Cell
Rights Holder(s)
SCOPUS
Bibliographic Citation
Cell (2025)
Suggested Citation
Kock K.H., Tan L.M., Han K.Y., Ando Y., Jevapatarakul D., Chatterjee A., Lin Q.X.X., Buyamin E.V., Sonthalia R., Rajagopalan D., Tomofuji Y., Sankaran S., Park M.S., Abe M., Chantaraamporn J., Furukawa S., Ghosh S., Inoue G., Kojima M., Kouno T., Lim J., Myouzen K., Nguantad S., Oh J.M., Rayan N.A., Sarkar S., Suzuki A., Thungsatianpun N., Venkatesh P.N., Moody J., Nakano M., Chen Z., Tian C., Zhang Y., Tong Y., Tan C.T.Y., Tizazu A.M., Loh M., Hwang Y.Y., Ho R.C., Larbi A., Ng T.P., Won H.H., Wright F.A., Villani A.C., Park J.E., Choi M., Liu B., Maitra A., Pithukpakorn M., Suktitipat B., Ishigaki K., Okada Y., Yamamoto K., Carninci P., Chambers J.C., Hon C.C., Matangkasombut P., Charoensawan V., Majumder P.P., Shin J.W., Park W.Y., Prabhakar S. Asian diversity in human immune cells. Cell (2025). doi:10.1016/j.cell.2025.02.017 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/108517
Title
Asian diversity in human immune cells
Author(s)
Kock K.H.
Tan L.M.
Han K.Y.
Ando Y.
Jevapatarakul D.
Chatterjee A.
Lin Q.X.X.
Buyamin E.V.
Sonthalia R.
Rajagopalan D.
Tomofuji Y.
Sankaran S.
Park M.S.
Abe M.
Chantaraamporn J.
Furukawa S.
Ghosh S.
Inoue G.
Kojima M.
Kouno T.
Lim J.
Myouzen K.
Nguantad S.
Oh J.M.
Rayan N.A.
Sarkar S.
Suzuki A.
Thungsatianpun N.
Venkatesh P.N.
Moody J.
Nakano M.
Chen Z.
Tian C.
Zhang Y.
Tong Y.
Tan C.T.Y.
Tizazu A.M.
Loh M.
Hwang Y.Y.
Ho R.C.
Larbi A.
Ng T.P.
Won H.H.
Wright F.A.
Villani A.C.
Park J.E.
Choi M.
Liu B.
Maitra A.
Pithukpakorn M.
Suktitipat B.
Ishigaki K.
Okada Y.
Yamamoto K.
Carninci P.
Chambers J.C.
Hon C.C.
Matangkasombut P.
Charoensawan V.
Majumder P.P.
Shin J.W.
Park W.Y.
Prabhakar S.
Tan L.M.
Han K.Y.
Ando Y.
Jevapatarakul D.
Chatterjee A.
Lin Q.X.X.
Buyamin E.V.
Sonthalia R.
Rajagopalan D.
Tomofuji Y.
Sankaran S.
Park M.S.
Abe M.
Chantaraamporn J.
Furukawa S.
Ghosh S.
Inoue G.
Kojima M.
Kouno T.
Lim J.
Myouzen K.
Nguantad S.
Oh J.M.
Rayan N.A.
Sarkar S.
Suzuki A.
Thungsatianpun N.
Venkatesh P.N.
Moody J.
Nakano M.
Chen Z.
Tian C.
Zhang Y.
Tong Y.
Tan C.T.Y.
Tizazu A.M.
Loh M.
Hwang Y.Y.
Ho R.C.
Larbi A.
Ng T.P.
Won H.H.
Wright F.A.
Villani A.C.
Park J.E.
Choi M.
Liu B.
Maitra A.
Pithukpakorn M.
Suktitipat B.
Ishigaki K.
Okada Y.
Yamamoto K.
Carninci P.
Chambers J.C.
Hon C.C.
Matangkasombut P.
Charoensawan V.
Majumder P.P.
Shin J.W.
Park W.Y.
Prabhakar S.
Author's Affiliation
Biotechnology Research and Innovation Council
RIKEN Center for Integrative Medical Sciences
Institute for Health Innovation & Technology
Fondazione Human Technopole
Faculty of Science, Mahidol University
Siriraj Hospital
Lee Kong Chian School of Medicine
A-Star, Singapore Immunology Network
Cancer Science Institute of Singapore
Khoo Teck Puat Hospital
WPI Immunology Frontier Research Center, Osaka University
Korea Advanced Institute of Science and Technology
A-Star, Genome Institute of Singapore
Hiroshima University
NUS Yong Loo Lin School of Medicine
Suranaree University of Technology
The University of Tokyo
Indian Statistical Institute, Kolkata
Osaka University
Samsung Medical Center, Sungkyunkwan university
National University of Singapore
Riken
Osaka University Faculty of Medicine
Mahidol University
Massachusetts General Hospital Cancer Center
Sungkyunkwan University
NC State University
Harvard Medical School
Broad Institute
Seoul National University College of Medicine
Geriatric Education and Research Institute
John C. Martin Centre for Liver Research and Innovations
St Luke's Hospital
RIKEN Center for Integrative Medical Sciences
Institute for Health Innovation & Technology
Fondazione Human Technopole
Faculty of Science, Mahidol University
Siriraj Hospital
Lee Kong Chian School of Medicine
A-Star, Singapore Immunology Network
Cancer Science Institute of Singapore
Khoo Teck Puat Hospital
WPI Immunology Frontier Research Center, Osaka University
Korea Advanced Institute of Science and Technology
A-Star, Genome Institute of Singapore
Hiroshima University
NUS Yong Loo Lin School of Medicine
Suranaree University of Technology
The University of Tokyo
Indian Statistical Institute, Kolkata
Osaka University
Samsung Medical Center, Sungkyunkwan university
National University of Singapore
Riken
Osaka University Faculty of Medicine
Mahidol University
Massachusetts General Hospital Cancer Center
Sungkyunkwan University
NC State University
Harvard Medical School
Broad Institute
Seoul National University College of Medicine
Geriatric Education and Research Institute
John C. Martin Centre for Liver Research and Innovations
St Luke's Hospital
Corresponding Author(s)
Other Contributor(s)
Abstract
The relationships of human diversity with biomedical phenotypes are pervasive yet remain understudied, particularly in a single-cell genomics context. Here, we present the Asian Immune Diversity Atlas (AIDA), a multi-national single-cell RNA sequencing (scRNA-seq) healthy reference atlas of human immune cells. AIDA comprises 1,265,624 circulating immune cells from 619 donors, spanning 7 population groups across 5 Asian countries, and 6 controls. Though population groups are frequently compared at the continental level, we found that sub-continental diversity, age, and sex pervasively impacted cellular and molecular properties of immune cells. These included differential abundance of cell neighborhoods as well as cell populations and genes relevant to disease risk, pathogenesis, and diagnostics. We discovered functional genetic variants influencing cell-type-specific gene expression, which were under-represented in non-Asian populations, and helped contextualize disease-associated variants. AIDA enables analyses of multi-ancestry disease datasets and facilitates the development of precision medicine efforts in Asia and beyond.