Factors Influencing Bronchopulmonary Dysplasia: An Eight-Year Study in a Single Tertiary Care Unit in Thailand
Issued Date
2025-01-01
Resource Type
eISSN
22288082
Scopus ID
2-s2.0-85216941721
Journal Title
Siriraj Medical Journal
Volume
77
Issue
2
Start Page
158
End Page
167
Rights Holder(s)
SCOPUS
Bibliographic Citation
Siriraj Medical Journal Vol.77 No.2 (2025) , 158-167
Suggested Citation
Moolmai P., Rattanachamnongk P., Yangthara B., Wutthigate P. Factors Influencing Bronchopulmonary Dysplasia: An Eight-Year Study in a Single Tertiary Care Unit in Thailand. Siriraj Medical Journal Vol.77 No.2 (2025) , 158-167. 167. doi:10.33192/smj.v77i2.271246 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/105300
Title
Factors Influencing Bronchopulmonary Dysplasia: An Eight-Year Study in a Single Tertiary Care Unit in Thailand
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Corresponding Author(s)
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Abstract
Objective: To assess the incidence trends of severe BPD or death, identify associated risk factors, and develop a predictive model using Jensen’s BPD grading system. Materials and Methods: This retrospective study included infants with a gestational age (GA) < 32 weeks born between 2013 and 2020. Infants were classified into no BPD and BPD (all grades) or death categories. Risk factors and a predictive model for outcomes were identified using multivariable logistic regression and evaluated with a receiver operating characteristic (ROC) curve. Results: Among the 772 infants, 286 (37%) were classified into the BPD group. The incidence of BPD continuously increased from 16.3% in 2013 to 49.4% in 2020. Multivariate analyses revealed factors associated with severe BPD, including IUGR, the 1-minute Apgar score, surfactant administration, late-onset sepsis, hydrocortisone, PDA ligation, postnatal steroid and mechanical ventilation (MV) days. The highest adjusted odds ratio (aOR) was for MV?> 42 days at 19.29 (95% CI; 7.22–51.55; p<0.001). The area under the curve (AUC) was 0.898, with 80.68% sensitivity and 84.83% specificity. Conclusion: When Jensen’s criteria were used, the incidence and risk factors for severe BPD or death in Thai neonates were similar to those reported in previous studies. The regression model exhibited good predictive value, potentially assisting clinicians in targeted interventions.
