Potential antihypertensive activity of novel peptides from green basil leaves
1
Issued Date
2023-08-08
Resource Type
eISSN
26627671
Scopus ID
2-s2.0-85167370414
Pubmed ID
37553559
Journal Title
BMC complementary medicine and therapies
Volume
23
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
BMC complementary medicine and therapies Vol.23 No.1 (2023) , 282
Suggested Citation
Prangthip P., Panbangred W., Reamtong O. Potential antihypertensive activity of novel peptides from green basil leaves. BMC complementary medicine and therapies Vol.23 No.1 (2023) , 282. doi:10.1186/s12906-023-04098-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/88353
Title
Potential antihypertensive activity of novel peptides from green basil leaves
Author(s)
Other Contributor(s)
Abstract
Hypertension is among the risk factors of death globally. Novel antihypertensive peptides are alternative choices of antihypertensive assistance. This study aimed to discover novel antihypertensive peptides from green basil leaves. Two bioactive peptides with high angiotensin-converting enzyme inhibition (Asp-Leu-Ser-Ser-Ala-Pro; peptide 1) and antioxidant (Asp-Ser-Val-Ser-Ala-Ser-Pro; peptide 2) activities were gavaged to male Wistar rats induced with NG-nitro-l-arginine methyl-ester (L-NAME). L-NAME-treated rats (HT) had decreased body weights and levels of nitrite and nitrate, which are metabolites of nitric oxide. The levels of their glucose and liver function indicators increased as compared to normal rats. HT rats receiving antihypertensive drugs (HTD) showed higher low-density lipoprotein and low-density lipoprotein/high-density lipoprotein levels than HT rats. Peptide 1 seems to benefit the rat lipid profiles, liver functions, antioxidant, nitrite, nitrate, and angiotensin II peptide levels but not peptide 2. In conclusion, our findings indicate the antihypertensive potential related to vasodilation of peptides from green basil leaves.