MYELOstudy: lymph node stage of aggressiveness in medullary thyroid cancer—a retrospective multi-center study analysis
2
Issued Date
2026-01-01
Resource Type
ISSN
2038131X
eISSN
20383312
Scopus ID
2-s2.0-105033273528
Journal Title
Updates in Surgery
Rights Holder(s)
SCOPUS
Bibliographic Citation
Updates in Surgery (2026)
Suggested Citation
Papavramidis T., Chorti A., Bakkar S., Raffaelli M., Košec A., Hoang V.T., Lim J.Y., Genc V., Minuto M.N., Calò P.G., Hellmann A., Di Filippo G., Karakozis L., Chrisoulidou A., Gamgaram V.K.D., Sriphrapradang C., Leclère J.C., Orois A., Marco D., Dhiwakar M., de Pasquale L., Buemi A., Nesti C., Pandev R., Chala A., Yalıman S.S., Hajiioannou J., Liu S.Y.W., Cherenko S., Voloudakis N., Koutelidakis I., Nastos K., Constanza R., Dobrinja C., Brunner M., Bains L., Panchangam R.B., Girardi F.M., Arikan A.E., El Malki H.O., de Cillia M., Oragano L., Pliakos I., Moysidis M., Pennestrì F., De Crea C., Čukman M., Tarle A., Senashova O.S., Shindo M.L., Tüzken İ., Turhan M.A., Varaldo E., Albertelli M., Medas F., Canu G.L., Cappellacci F., Śledziński M., Lazzari G., Morelli E., Karakozis S., Boudina M., Katsamakas M., Guevara M.I., Aroonroch R., Manyalich M., Vidal O., Triponez F., Masse N., Kathirvel L., Muthusamy R., La Rubia P., Castellani L., Maria-Cristina B., Raluca-Maria F., Kaderli R., Teksoz S., Chow T.C.M., Lai M.S., Shchekaturova L., Bellou E., Banus M., Da Milano R., Mastronardi M., Grützmann R., Hauth L.A., Abentroth A.L., Dulgeroglu O., Uras C., Placentino G., Leutner M. MYELOstudy: lymph node stage of aggressiveness in medullary thyroid cancer—a retrospective multi-center study analysis. Updates in Surgery (2026). doi:10.1007/s13304-025-02513-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/115907
Title
MYELOstudy: lymph node stage of aggressiveness in medullary thyroid cancer—a retrospective multi-center study analysis
Author(s)
Papavramidis T.
Chorti A.
Bakkar S.
Raffaelli M.
Košec A.
Hoang V.T.
Lim J.Y.
Genc V.
Minuto M.N.
Calò P.G.
Hellmann A.
Di Filippo G.
Karakozis L.
Chrisoulidou A.
Gamgaram V.K.D.
Sriphrapradang C.
Leclère J.C.
Orois A.
Marco D.
Dhiwakar M.
de Pasquale L.
Buemi A.
Nesti C.
Pandev R.
Chala A.
Yalıman S.S.
Hajiioannou J.
Liu S.Y.W.
Cherenko S.
Voloudakis N.
Koutelidakis I.
Nastos K.
Constanza R.
Dobrinja C.
Brunner M.
Bains L.
Panchangam R.B.
Girardi F.M.
Arikan A.E.
El Malki H.O.
de Cillia M.
Oragano L.
Pliakos I.
Moysidis M.
Pennestrì F.
De Crea C.
Čukman M.
Tarle A.
Senashova O.S.
Shindo M.L.
Tüzken İ.
Turhan M.A.
Varaldo E.
Albertelli M.
Medas F.
Canu G.L.
Cappellacci F.
Śledziński M.
Lazzari G.
Morelli E.
Karakozis S.
Boudina M.
Katsamakas M.
Guevara M.I.
Aroonroch R.
Manyalich M.
Vidal O.
Triponez F.
Masse N.
Kathirvel L.
Muthusamy R.
La Rubia P.
Castellani L.
Maria-Cristina B.
Raluca-Maria F.
Kaderli R.
Teksoz S.
Chow T.C.M.
Lai M.S.
Shchekaturova L.
Bellou E.
Banus M.
Da Milano R.
Mastronardi M.
Grützmann R.
Hauth L.A.
Abentroth A.L.
Dulgeroglu O.
Uras C.
Placentino G.
Leutner M.
Chorti A.
Bakkar S.
Raffaelli M.
Košec A.
Hoang V.T.
Lim J.Y.
Genc V.
Minuto M.N.
Calò P.G.
Hellmann A.
Di Filippo G.
Karakozis L.
Chrisoulidou A.
Gamgaram V.K.D.
Sriphrapradang C.
Leclère J.C.
Orois A.
Marco D.
Dhiwakar M.
de Pasquale L.
Buemi A.
Nesti C.
Pandev R.
Chala A.
Yalıman S.S.
Hajiioannou J.
Liu S.Y.W.
Cherenko S.
Voloudakis N.
Koutelidakis I.
Nastos K.
Constanza R.
Dobrinja C.
Brunner M.
Bains L.
Panchangam R.B.
Girardi F.M.
Arikan A.E.
El Malki H.O.
de Cillia M.
Oragano L.
Pliakos I.
Moysidis M.
Pennestrì F.
De Crea C.
Čukman M.
Tarle A.
Senashova O.S.
Shindo M.L.
Tüzken İ.
Turhan M.A.
Varaldo E.
Albertelli M.
Medas F.
Canu G.L.
Cappellacci F.
Śledziński M.
Lazzari G.
Morelli E.
Karakozis S.
Boudina M.
Katsamakas M.
Guevara M.I.
Aroonroch R.
Manyalich M.
Vidal O.
Triponez F.
Masse N.
Kathirvel L.
Muthusamy R.
La Rubia P.
Castellani L.
Maria-Cristina B.
Raluca-Maria F.
Kaderli R.
Teksoz S.
Chow T.C.M.
Lai M.S.
Shchekaturova L.
Bellou E.
Banus M.
Da Milano R.
Mastronardi M.
Grützmann R.
Hauth L.A.
Abentroth A.L.
Dulgeroglu O.
Uras C.
Placentino G.
Leutner M.
Author's Affiliation
Chinese University of Hong Kong
Università degli Studi di Genova
Oregon Health & Science University
Hospital Clínic de Barcelona
Università degli Studi di Trieste
Ankara Üniversitesi
Università degli Studi di Cagliari
University Hospital Bern
Hôpitaux Universitaires de Genève
IRCCS San Martino Polyclinic Hospital
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Universitätsklinikum Erlangen
Mohammed V University in Rabat
Gdanski Uniwersytet Medyczny
Cliniques Universitaires Saint-Luc
Medical University of Sofia
İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine
Hashemite University
Azienda Ospedaliera Universitaria Integrata Verona
Centre Hospitalier Universitaire de Brest
Maulana Azad Medical College
Hospital Regional Universitario Carlos Haya
Klinički Bolnički Centar Sestre Milosrdnice
Acıbadem Mehmet Ali Aydınlar Üniversitesi
University General Hospital of Thessaloniki "AHEPA"
Ospedale San Paolo
Faculty of Medicine Ramathibodi Hospital, Mahidol University
University Hospital of Larissa
Universidad de Caldas
Hospital Privado Centro Medico de Cordoba
Kovai Medical Center and Hospital
Evgenidion Hospital
Thien Hanh Hospital
Hospital Ana Nery
Gennimatas General Hospital
Saint John of God Hospital
Theageneio Cancer Hospital
International Medical Center “CITI DOCTOR”
Bhargav Endocrine Hospital
Thyroid Surgery Clinic IKE
San Biagio” Hospital - ASL VCO - Domodossola (VB)
Università degli Studi di Genova
Oregon Health & Science University
Hospital Clínic de Barcelona
Università degli Studi di Trieste
Ankara Üniversitesi
Università degli Studi di Cagliari
University Hospital Bern
Hôpitaux Universitaires de Genève
IRCCS San Martino Polyclinic Hospital
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Universitätsklinikum Erlangen
Mohammed V University in Rabat
Gdanski Uniwersytet Medyczny
Cliniques Universitaires Saint-Luc
Medical University of Sofia
İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine
Hashemite University
Azienda Ospedaliera Universitaria Integrata Verona
Centre Hospitalier Universitaire de Brest
Maulana Azad Medical College
Hospital Regional Universitario Carlos Haya
Klinički Bolnički Centar Sestre Milosrdnice
Acıbadem Mehmet Ali Aydınlar Üniversitesi
University General Hospital of Thessaloniki "AHEPA"
Ospedale San Paolo
Faculty of Medicine Ramathibodi Hospital, Mahidol University
University Hospital of Larissa
Universidad de Caldas
Hospital Privado Centro Medico de Cordoba
Kovai Medical Center and Hospital
Evgenidion Hospital
Thien Hanh Hospital
Hospital Ana Nery
Gennimatas General Hospital
Saint John of God Hospital
Theageneio Cancer Hospital
International Medical Center “CITI DOCTOR”
Bhargav Endocrine Hospital
Thyroid Surgery Clinic IKE
San Biagio” Hospital - ASL VCO - Domodossola (VB)
Corresponding Author(s)
Other Contributor(s)
Abstract
Medullary thyroid carcinoma (MTC) is a rare, but biologically aggressive cancer that accounts for 1–2% of all thyroid malignancies. Its aggressiveness has been linked to distinct clinicopathological features. Novel pathological predictors of aggressiveness have also been described in the literature. However, these remain contentious, to date. To assess the prognosticators of aggressiveness for MTC and establish potentially novel ones. The primary endpoint was to establish predictors for central and/or lateral cervical nodal metastatic disease. Whereas secondary endpoints include defining biochemical and histopathologic markers of aggressiveness. A multi-center retrospective analysis of prognosticators of aggressiveness in MTC. 785 patients with MTC were enrolled. The mean age was 56 years with a female to male ratio of 1: 1.7. Regression analysis demonstrated that aggressive prognosticator predictive of nodal metastasis included: age, pre- and post-operative Calcitonin and CEA levels, tumor size, multifocality, capsular and lymphovascular invasion, the presence of extrathyroidal extension, Ki-67, and RET positivity, desmoplasia, and inflammatory scores. This study provides an expanded spectrum of prognosticators of tumor aggressiveness. Furthermore, it also highlights the potential meaningful therapeutic implications of preoperative inflammatory scores, tumor desmoplastic reaction, and metastatic nodal ratio.