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Publication Metadata only Oestrogen-receptor-α gene polymorphism affects response in bone mineral density to oestrogen in post-menopausal women(2000-06-19) Boonsong Ongphiphadhanakul; S. Chanprasertyothin; P. Payatikul; S. Sae Tung; N. Piaseu; L. Chailurkit; S. Chansirikarn; G. Puavilai; R. Rajatanavin; Mahidol University; Division of EndocrinologyOBJECTIVE: An oestrogen-receptor-α (ERα) gene polymorphism has been variably reported to be related to bone mass. To investigate whether this ERα gene polymorphism is associated with a functional difference, we assessed the response in bone mineral... density (BMD) to oestrogen therapy in postmenopausal women in relation to ERα gene polymorphism. PATIENTS AND MEASUREMENTS: Subjects consisted of 124 Thai post-menopausal women. Sixty- three of the women were less than 6 years post-menopausal and 61 werePublication Metadata only Impact of vitamin D receptor gene polymorphisms on blood lead levels in Thai lead exposed workers(2012-02-01) Winai Wananukul; Tanyachai Sura; Krongtong Yoovathaworn; Nirada Kasiwut; Boonsong Ongphiphadhanakul; Mahidol Universityof BsmI and the tt genotype of TaqI have significantly lower blood lead levels than other genotypes of their polymorphisms. Conclusion: The BsmI and TaqI polymorphisms of the vitamin D receptor gene had impact on the blood lead level. This association...Background: Although lead poisoning has aroused public concern, its toxicokinetics and mechanism of toxicity are still unclear. Vitamin D regulates calcium homeostasis via vitamin D receptor (VDR) and its polymorphisms cause variability of bodyPublication Metadata only Genetic polymorphisms of estrogen receptor-α: Possible implications for targeted osteoporosis therapy(2003-03-22) Boonsong Ongphiphadhanakul; Mahidol University), and others. A number of association studies have been performed with single nucleotide polymorphisms in the ERα gene to assess their relation with bone mineral density in pre- and postmenopausal women, as well as the rate of bone loss after menopause...Genetic factors play an important role in the determination of bone mass and osteoporosis. A number of candidate genes have been implicated in osteoporosis, including genes encoding type 1 collagen, vitamin D receptor, estrogen receptor-α (ERαPublication Metadata only Serum oestradiol and oestrogen-receptor gene polymorphism are associated with bone mineral density independently of serum testosterone in normal males(1998-12-01) Boonsong Ongphiphadhanakul; R. Rajatanavin; S. Chanprasertyothin; N. Piaseu; L. Chailurkit; Mahidol University; Faculty of Medicine, Ramathibodi Hospital, Mahidol University) compared to that of free testosterone (FT) with bone mineral density (BMD) in normal men. The effect of oestrogen receptor (ER) gene polymorphism on BMD in men was also addressed. SUBJECTS Eighty-one Thai men aged 20-79 years. All were healthy and did... with higher BMD at AP L2-L4 (P < 0.05). CONCLUSIONS Serum oestradiol is more related to bone mass than free testosterone in normal men. Oestrogen-receptor gene polymorphism is also associated with bone mass in men independently of oestradiol levels. SerumPublication Metadata only The association of soluble IGF2R and IGF2R gene polymorphism with type 2 diabetes(2015-01-01) Suwannee Chanprasertyothin; Wallaya Jongjaroenprasert; Boonsong Ongphiphadhanakul; Mahidol UniversityCopyright © 2015 Suwannee Chanprasertyothin et al. The aim of this study is to investigate the insulin-like growth factor type 2 (IGF2R) gene and circulating soluble IGF2R in relation to type 2 diabetes (T2DM). Six hundred fifty-four subjects... was measured by colorimetric method; insulin levels were determined by chemiluminescent method; IGF2R gene rs416572 was genotyped using real-time PCR. The distributions of IGF2R genotypes were 69.2% CC, 27.8% CT, and 3.0% TT. The C allele was more commonlyPublication Metadata only Osteoporosis: The role of genetics and the environment(2007-08-23) Boonsong Ongphiphadhanakul; Mahidol Universitypreventive or therapeutic measures to subjects genetically determined to have better responsiveness. Intestinal calcium absorption is dependent on vitamin D receptor gene polymorphisms. Skeletal responsiveness to estrogen, particularly at lower doses..., is related to polymorphisms in the estrogen receptor-α gene. Recently, circulating homocysteine levels have been shown to be associated with fracture risk. Folate and vitamin B supplements for reducing serum homocysteine and fractures in postmenopausal womenPublication Metadata only Vitamin D binding protein gene polymorphism as a risk factor for Vitamin D deficiency in thais(2015-03-01) Pranee Thongthai; La Or Chailurkit; Suwannee Chanprasertyothin; Hataikarn Nimitphong; Piyamitr Sritara; Wichai Aekplakorn; Boonsong Ongphiphadhanakul; Mahidol Universitydeficiency including age, sex, and BMI.Conclusion: A specific GC gene polymorphism is associated with lower 25(OH)D levels independent of age, sex, and adiposity in Thai subjects....© 2015 AACE. Objective: Vitamin D deficiency is related to increased risks for a number of diseases. To date, at least 3 candidate genes, vitamin D binding protein (VDBP) gene (GC), 25-hydroxylase (CYP2R1), and 7-dehydrocholesterol reductase/NADPublication Metadata only The association of bone mineral density and G2014A polymorphism in the estrogen receptor alpha gene in osteoporotic hip fracture in Thai population(2015-01-01) Wiwat Wajanavisit; Sakda Suppachokmongkorn; Patarawan Woratanarat; Boonsong Ongphiphadhanakul; Tulyapruek Tawonsawatruk; Mahidol University© 2015, Medical Association of Thailand. All right reserved. Objective: This study aimed to determine the association of a recent identified G2014A single nucleotide polymorphism (SNP) genotype distribution in exon 8 of the estrogen receptor... distribution of gene G2014A SNP were G/G 23.1%, G/A 29.2% and A/A 47.7%. There was no statistical difference between age and BMI in each genotype. Gene G2014A was associated with osteoporosis of lumbar spine, femoral neck, ward triangle, and femoral neckPublication Metadata only Effect of GGCX gene polymorphism on the responses of serum undercarboxylated osteocalcin and bone turnover markers after treatment with vitamin K2 (menatetrenone) among postmenopausal Thai women(2011-09-01) Thawee Songpatanasilp; La Or Chailurkit; Suwannee Chantprasertyothin; Boonsong Ongphiphadhanakul; Nimit Taechakraichana; Phramongkutklao College of Medicine; Mahidol University; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Chulalongkorn UniversityThe purpose of this study was to evaluate the influence of gamma-glutamyl transferase (GGCX) gene polymorphisms on the response of serum undercarboxylated osteocalcin (ucOC) and bone turnover markers 3 months after treatment with menatetrenone. One... of postmenopausal women who 65 years of age or over (N = 37) revealed a significant difference between the two groups in the reduction of ucOC. Menatetrenone significantly reduced serum ucOC as well as beta-CTX and P1NP from the baseline. GGCX polymorphism appearedPublication Metadata only Correlation of apolipoprotein E gene polymorphism to serum lipid concentrations in healthy Thais(2000-10-01) Suwannee Chanprasertyothin; Boonsong Ongphiphadhanakul; Rajata Rajatanavin; Noppawan Piaseu; La Or Chailurkit; Gobchai Puavilai; Mahidol UniversityThis study determined the genotype distribution of apolipoprotein E (apo E) gene and its relation to serum lipids in 217 healthy Thais consisting of 79 males and 138 females. Serum total cholesterol (TC), HDL-cholesterol (HDL-C) and triglyceride (TG... concluded that the ε4 allele of apo E gene is rare in Thais. The presence of the ε2 allele is associated with a more favorable lipid profile and there is a sexual dimorphism concerning the effect of apo E genotype on serum HDL-C and TG.
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