3 results
Search Results
Now showing 1 - 3 of 3
Publication Metadata only Cost-utility analysis of drugs for secondary bone fracture prevention among post-menopausal osteoporotic patients in Thailand(2021-01-01) Emika Wiroonpochit; Nattiya Kapol; Surasit Lochid-Amnuay; Sawinee Chokchalermwong; Boonsong Ongphiphadhanakul; Ramathibodi Hospital; Silpakorn University; Nakhon Pathom Hospital. The model compared the expected costs and outcomes of calcium plus vitamin D alone (standard regimen) with those of calcium plus vitamin D with adjunct bisphosphonates (alendronate or risedronate), raloxifene, strontium, denosumab, or teriparatidePublication Open Access Thai traditional massage increases biochemical markers of bone formation in postmenopausal women: a randomized crossover trial(2013) Sunee Saetung; La-or Chailurkit; Boonsong Ongphiphadhanakul; Mahidol University. Ramathibodi Hospital. Department of MedicineBackground: The effect of massage therapy on bone metabolism in adults has only scarcely been explored. In a randomized crossover trial, we investigated the skeletal effect of Thai traditional massage by examining the changes in biochemical markers of bone turnover. Methods: Forty-eight postmenopausal women participated in the study. All volunteers were randomized to a 2-hour session of Thai traditional massage twice a week for 4 weeks and a 4-week control period after a 2-week washout, or vice versa. Twenty-one subjects were allocated to receiving Thai traditional massage first, followed by the control period, while 27 were initially allocated to the control period. Results: Serum P1NP increased significantly after Thai traditional massage (P <0.01), while there was no change in serum osteocalcin or CTX. During the control period, there was no significant change in P1NP, osteocalcin or CTX compared to baseline. When age and height were taken into account, P1NP in postmenopausal women whose ages were in the middle and higher tertiles and whose heights were in the lower and middle tertiles (n = 22) had a 14.8 ± 3.3% increase in P1NP after massage (P <0.001), while no change in P1NP was found in the rest of the women (n = 26). Conclusions: Thai traditional massage results in an increase in bone formation as assessed by serum P1NP, particularly in postmenopausal women who are older and have a smaller body build. Future studies with larger samples and additional design features are warranted.Publication Open Access Postmenopausal Osteoporosis in Relation to Toll-like Receptor-7 and HLA DQB1 Gene Expression on Peripheral Blood Mononuclear Cells(2016) Wanwisa Waiyaput; Mayuree Jirapinyo; Charnchai Suchartwattanachai; Boonsong Ongphiphadhanakul; Somphoch Pumipichet; Areepan Sophonsritsuk; วรรณวิสา ไวยพุฒ; มยุรี จิรภิญโญ; ชาญชัย สุชาติวัฒนชัย; บุญส่ง องค์พิพัฒนกุล; สมโภช ภูมิพิเชฐ; อารีย์พรรณ โสภณสฤษฎ์สุข; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Research, and Innovation; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Department of Obstetrics and Gynecology; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Department of MedicineBackground: Data from genome wide association study have demonstrated that the toll-like receptor-7 gene (TLR7), a well-known role in innate immunity, may participate in the development of postmenopausal osteoporosis. The HLA DQB1 gene is part of human leukocyte antigen (HLA) complex. HLA DQB1 plays a critical role in the immune system. Objective: To determine the association of postmenopausal osteoporosis and transcripts of TLR7 and HLA DQB1 from peripheral blood mononuclear cells (PBMCs). Methods: The study groups included 25 postmenopausal women with normal bone mineral density (BMD) and the other 25 women with osteoporosis. Blood was drawn from the subjects for bone markers and PBMCs preparation. RNA was then isolated and quantitative RT-PCR was performed for TLR7 and HLA DQB1 genes. Results: PBMCs expression of both TLR7 and HLA DQB1 were not significantly different between postmenopausal women with normal BMD and those with osteoporosis. (P = 0.567 and P = 0.248, respectively). Conclusions: It is unlikely that TLR7 and HLA DQB1 contribute a major role on postmenopausal osteoporosis in Thai women.