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Publication Metadata only Monocyte chemoattractant protein 1 (MCP-1) gene polymorphism is not associated with severe and cerebral malaria in Thailand(2006-09-05) Naowarut Dechkum; Hathairad Hananantachai; Jintana Patarapotikul; Jun Ohashi; Srivicha Krudsood; Sornchai Looareesuwan; Katsushi Tokunaga; Mahidol University; University of Tokyo, we here study MCP-1 gene polymorphisms in association with severe or cerebral malaria in Thailand. Malaria patients in the northwest of Thailand were grouped into mild (n = 206), severe (165), and cerebral (110) malaria case groups. Five single... haplotypes. The most common haplotype was GGAC. The results indicated that MCP-1 gene polymorphisms were not associated with malaria severity, implying that MCP-1 was not a cause of malaria severity in this Thai population.Publication Metadata only R219K Polymorphism of ATP Binding Cassette Transporter A1 Related with Low HDL in Overweight/Obese Thai Males(2007-11-01) Anong Kitjaroentham; Hathairad Hananantachai; Anchalee Tungtrongchitr; Somchai Pooudong; Rungsunn Tungtrongchitr; Mahidol University; Faculty of Medicine, Siriraj Hospital, Mahidol Universityand familial hypoalphalipoproteinemia. The aim of this study was to elucidate whether the presence of ABCA1 gene polymorphism could be a risk factor for overweight/obesity. Methods: The presence of R219K and I883M genetic variant was determined by PCR-RFLP... the possible involvement of this gene with obesity, further investigations are needed to prove the influence of ABCA1 gene polymorphism on HDL level and to determine whether it could be a genetic determinant of obesity. © 2007 IMSS.Publication Metadata only Absence of association between the Fcγ receptor IIIA-176F\ V polymorphism and the severity of malaria in Thai(2002-10-01) Kazuya Omi; Jun Ohashi; Jintana Patarapotikul; Hathairad Hananantachai; Izumi Naka; Sornchai Looareesuwan; Katsushi Tokunaga; Mahidol University; University of Tokyois associated with susceptibility to cerebral malaria, and that such an association can be caused by linkage disequilibrium (LD) between these polymorphisms and the primary associated gene(s) in this region. FcγRIIIA is known to exhibit the genetic polymorphism...Human Fcγ receptor (FcγR) genes form a clustered gene family, which consists of Fcγ RIIA, IIB, IIC, IIIA, and IIIB genes, on chromosome 1q23. We previously reported that the Fcγ RIIA-131H/H genotype in combination with the FcγRIIIB-NA2 allelePublication Metadata only Polymorphisms of the HLA-B and HLA-DRB1 genes in Thai malaria patients(2005-02-01) Hathairad Hananantachai; Jintana Patarapotikul; Jun Ohashi; Izumi Naka; Sornchai Looareesuwan; Katsushi Tokunaga; University of Tokyo; Mahidol UniversityThe high degree of polymorphism of human leukocyte antigen (HLA) genes has been suggested to result from natural selection against susceptibility to a variety of infectious pathogens, including malaria. HLA molecules are considered to play a crucial... for associations between HLA alleles and severity of malaria in a Thai population, polymorphisms of HLA-B and HLA-DRB1 genes were investigated in 472 adult patients in northwest Thailand with Plasmodium falciparum malaria. In this study, malaria patients wereItem Metadata only A possible association between FCGR polymorphisms and severity of malaria in Thai(2002) Omi, Kazuya; Ohashi, Jun; Jintana Patarapotikul; จินตนา ภัทรโพธิกุล; Hathairad Hananantachai; หทัยรัชต์ หาญอนันตชัย; Naka, Izumi; Sornchai Looareesuwan; ศรชัย หลูอารีย์สุวรรณ; Tokunaga, Katsushi; Mahidol University. Faculty of Tropical medicineis associated with susceptibility to cerebral malaria, while such an association can be caused by linkage disequilibrium (LD) between these polymorphisms and the primary associated gene (s) in this region. FCGRIIIA is known to exhibit genetic polymorphism...Human Fcγ receptor (FCGR) genes form a clustered gene family on chromosome 1q23, that consists of FCGRIA, IIB, IIC, IIIA, and IIIB genes. We previously reported that the FCGRIIA-131H/H genotype in combination with the FCGRIIIB-NA2 allelePublication Metadata only A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand(2005-08-14) Jun Ohashi; Izumi Naka; Akihiro Doi; Jintana Patarapotikul; Hathairad Hananantachai; Noppadon Tangpukdee; Sornchai Looareesuwan; Katsushi Tokunaga; University of Tokyo; Mahidol UniversityBackground: IL-1β and IL-1RA levels are higher in the serum of cerebral malaria patients than in patients with mild malaria. Recently, the level of IL1B expression was reported to be influenced by a polymorphism in the promoter of IL1, IL1B -31C...>T. Methods: To examine whether polymorphisms in IL1B and IL1RA influence the susceptibility to cerebral malaria, IL1B -31C>T, IL1B 3953C>T, and IL1RA variable number of tandem repeat (VNTR) were analysed in 312 Thai patients with malaria (109 cerebral malariaItem Metadata only Lack of association of interleukin-10 gene promother polymorphism, -1082g/a, with severe malaria in Thailand(2001) Naka, Izumi; Ohashi, Jun; Jintana Patarapotikul; จินตนา ภัทรโพธิกุล; Hathairad Hananantachai; หทัยรัชต์ หาญอนันตชัย; Sornchai Looareesuwan; ศรชัย หลูอารีย์สุวรรณ; Tokunaga, Katsushi; Mahidol University. Faculty of Tropical MedicineInterleukin-10 (IL-10) is one of the immunoregulatory cytokines which influence the balance between T helper 1 and T helper 2 cells and plays an important role in the immune response to various pathogens. The IL-10 gene is located on chromosome 1q31...-32, and a promoter polymorphism-1082G/A is known to be involved in IL-10 protein production. In order to examine a possible association of the -1082G/A polymorphism with the severity of malaria, we analyzed 203 mild malaria, 164 non-cerebral severePublication Metadata only Low density lipoprotein receptor-related protein 5 gene polymorphisms and osteoporosis in Thai menopausal women(2016-09-01) Anong Kitjaroentham; Hathairad Hananantachai; Benjaluck Phonrat; Sangchai Preutthipan; Rungsunn Tungtrongchitr; Mahidol University-related protein 5 (LRP5), a co-receptor in the Wnt/beta-catenin pathway, is involved in many aspects of bone biology. As coding single nucleotide polymorphisms (cSNPs) of LRP5, including A1330V (rs3736228), and Asian-related Q89R (rs41494349) and N740N (rs...2306862), are associated with lowered BMD, this study aimed to determine the relationship between these LRP5 polymorphisms and BMD in 277 Thai menopausal women. Results: Only rs3736228 deviated from the Hardy-Weinberg equilibrium of allele frequency (p = 0Publication Metadata only CD36 polymorphism is associated with protection from cerebral malaria(2003-02-01) Kazuya Omi; Jun Ohashi; Jintana Patarapotikul; Hathairad Hananantachai; Izumi Naka; Sornchai Looareesuwan; Katsushi Tokunaga; University of Tokyo; Mahidol Universitydisequilibrium (LD) between the nine common polymorphisms revealed that there are two blocks with strong LD in the CD36 gene and that the - 14T→C and - 53G→T polymorphisms are within the upstream block of 35 kb from the upstream promoter to exon 8. Further...The human protein CD36 is a major receptor for Plasmodium falciparum-infected erythrocytes and contributes to the pathology of P. falciparum malaria. We performed variation screening of the CD36 gene and examined the possible association between CDPublication Open Access A functional polymorphism in the IL1B gene promoter, IL1B -31C>T, is not associated with cerebral malaria in Thailand.(2005-08-14) Ohashi, Jun; Naka, Izumi; Doi, Akihiro; Jintana Patarapotikul; จินตนา ภัทรโพธิกุล; Hathairad Hananantachai; Noppadon Tangpukdee; นพดล ตั้งภักดี; Sornchai Looareesuwan; ศรชัย หลูอารีย์สุวรรณ; Tokunaga, Katsushi; Mahidol University. Faculty of Tropical MedicineIL-1beta and IL-1RA levels are higher in the serum of cerebral malaria patients than in patients with mild malaria. Recently, the level of IL1B expression was reported to be influenced by a polymorphism in the promoter of IL1, IL1B -31C>T. METHODS...: To examine whether polymorphisms in IL1B and IL1RA influence the susceptibility to cerebral malaria, IL1B -31C>T, IL1B 3953C>T, and IL1RA variable number of tandem repeat (VNTR) were analysed in 312 Thai patients with malaria (109 cerebral malaria and 203
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