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Item Metadata only Enhanced bedside mortality prediction combining point-of-care lactate and the quick Sequential Organ Failure Assessment (qSOFA) score in patients hospitalised with suspected infection in southeast Asia: a cohort study(2022-09-01) Wright S.W.; Hantrakun V.; Rudd K.E.; Lau C.Y.; Lie K.C.; Chau N.V.V.; Teparrukkul P.; West T.E.; Limmathurotsakul D.; Mahidol Universitywith the quick Sequential Organ Failure Assessment (qSOFA) score in adult patients admitted to hospital with suspected infection in southeast Asia. Methods: We performed a cohort study by prospectively enrolling patients aged 18 years or older who had been... with the qSOFA score, a lactate score, and a modified Sequential Organ Failure Assessment (SOFA) score for mortality discrimination using the area under the receiver operating characteristic curve (AUROC). Mortality discrimination of the qSOFA-lactate scoreItem Metadata only Prognostic Accuracy of Screening Tools for Clinical Deterioration in Adults With Suspected Sepsis in Northeastern Thailand: A Cohort Validation Study(2024-05-01) Wixon-Genack J.; Wright S.W.; Cobb Ortega N.L.; Hantrakun V.; Rudd K.E.; Teparrukkul P.; Limmathurotsakul D.; West T.E.; Wixon-Genack J.; Mahidol UniversityScore (NEWS), the Modified Early Warning Score, Between the Flags, and the quick Sequential Organ Failure Assessment score. Scores were tested for predictive accuracy of clinical deterioration, defined as a new requirement of mechanical ventilation... area under the receiver operating characteristic curve. Results: Of 4989 enrolled patients, 2680 met criteria for secondary analysis, and 100 of 2680 (4%) experienced clinical deterioration within 1 day after enrollment. NEWS had the highestItem Metadata only External validation of clinical severity scores to guide referral of paediatric acute respiratory infections in resource-limited primary care settings(2023-12-01) Chandna A.; Mwandigha L.; Koshiaris C.; Limmathurotsakul D.; Nosten F.; Lubell Y.; Perera-Salazar R.; Turner C.; Turner P.; Mahidol UniversityAccurate and reliable guidelines for referral of children from resource-limited primary care settings are lacking. We identified three practicable paediatric severity scores (the Liverpool quick Sequential Organ Failure Assessment (Lq... within a refugee camp on the Thailand-Myanmar border. This secondary analysis of data from a longitudinal birth cohort study consisted of 3010 ARI presentations in children aged ≤ 24 months. The primary outcome was receipt of supplemental oxygen. WeItem Metadata only Pre-Referral Antibiotics and Mortality Among Adults With Sepsis in Southeast Asia: A Secondary Analysis of a Prospective Cohort Study(2026-01-01) Coston T.D.; Wright S.W.; Hantrakun V.; Rudd K.E.; Chamnan P.; Wongsuvan G.; West T.E.; Limmathurotsakul D.; Coston T.D.; Mahidol Universitycommunity hospitals to a tertiary center, we tested whether pre-referral antibiotic administration is associated with 28-day survival in sepsis, and whether this association differs by the presence of shock. DESIGN: Secondary analysis of a prospective cohort... total of 2593 adults with sepsis defined by primary diagnosis of infection and modified Sequential Organ Failure Assessment score greater than or equal to 2 who were referred from community hospitals. INTERVENTIONS: Antibiotics administeredItem Metadata only IL-1R2-based biomarker models predict melioidosis mortality independent of clinical data(2023-01-01) Kaewarpai T.; Wright S.W.; Yimthin T.; Phunpang R.; Dulsuk A.; Lovelace-Macon L.; Rerolle G.F.; Dow D.B.; Hantrakun V.; Day N.P.J.; Lertmemongkolchai G.; Limmathurotsakul D.; West T.E.; Chantratita N.; Mahidol University) regression, and mortality discrimination was compared to a clinical variable model by receiver operating characteristic curve analysis. Mortality prediction was confirmed in an external validation set of 191 prospectively enrolled patients hospitalized... for the IL-1R2 + sTREM-1 model (AUC 0.81, 95% CI 0.72–0.91) as well as for an IL-1R2-only model (AUC 0.78, 95% CI 0.68–0.88) were higher than for a model based on a modified Sequential Organ Failure Assessment (SOFA) score (AUC 0.69, 95% CI 0.56–0.81, p < 0