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Author: Mallika Imwong

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    Thiamin supplementation does not reduce the frequency of adverse events after anti-malarial therapy among patients with falciparum malaria in southern Laos
    (2014-07-15) Mayfong Mayxay; Maniphone Khanthavong; Lorna Cox; Odai Sichanthongthip; Mallika Imwong; Tiengkham Pongvongsa; Bouasy Hongvanthong; Samlane Phompida; Viengxay Vanisaveth; Nicholas J. White; Paul N. Newton; Mahosot Hospital; University of Health Sciences; University of Oxford; Centre of Malariology; MRC Human Nutrition Research; Mahidol University; Savannakhet Provincial Malaria Station
    responses to treatment did not differ significantly between the two groups. Conclusion: Thiamin supplementation reduced biochemical thiamin deficiency among Lao malaria patients following anti-malarial drug treatment, but it did not reduce the frequency
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    Combined effects of double mutations on catalytic activity and structural stability contribute to clinical manifestations of glucose-6-phosphate dehydrogenase deficiency
    (2021-12-01) Phonchanan Pakparnich; Sirapapha Sudsumrit; Mallika Imwong; Teeraporn Suteewong; Kamonwan Chamchoy; Danaya Pakotiprapha; Ubolsree Leartsakulpanich; Usa Boonyuen; Faculty of Tropical Medicine, Mahidol University; Chulabhorn Royal Academy; King Mongkut's Institute of Technology Ladkrabang; Mahidol University; Thailand National Center for Genetic Engineering and Biotechnology
    Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy in humans, affecting ~ 500 million worldwide. A detailed study of the structural stability and catalytic activity of G6PD variants is required to understand how... different mutations cause varying degrees of enzyme deficiency, reflecting the response of G6PD variants to oxidative stress. Furthermore, for G6PD double variants, investigating how two mutations jointly cause severe enzyme deficiency is important. Here, we
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    Detailed functional analysis of two clinical glucose-6-phosphate dehydrogenase (G6PD) variants, G6PDViangchanand G6PDViangchan + Mahidol: Decreased stability and catalytic efficiency contribute to the clinical phenotype
    (2016-06-01) Usa Boonyuen; Kamonwan Chamchoy; Thitiluck Swangsri; Naowarat Saralamba; Nicholas P.J. Day; Mallika Imwong; Mahidol University; Nuffield Department of Clinical Medicine
    © 2016 The Authors. Deficiency of glucose-6-phosphate dehydrogenase (G6PD) is an X-linked hereditary genetic defect that is the most common polymorphism and enzymopathy in humans. To investigate functional properties of two clinical variants, G6... efficiency are responsible for the reduced catalytic activity of G6PDViangchanand G6PDViangchan + Mahidoland, as a consequence, contribute to the clinical phenotypes of these two clinical variants.
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    Molecular characterization of dihydrofolate reductase in relation to antifolate resistance in Plasmodium vivax
    (2002-01-15) Ubolsree Leartsakulpanich; Mallika Imwong; Sasithon Pukrittayakamee; Nicholas J. White; Georges Snounou; Worachart Sirawaraporn; Yongyuth Yuthavong; Thailand National Center for Genetic Engineering and Biotechnology; Mahidol University; Nuffield Department of Clinical Medicine; Institut Pasteur, Paris
    The genes encoding the wild-type and six (five single and one double) mutant dihydrofolate reductase (DHFR) domains of the human malaria parasite, Plasmodium vivax (Pv), were cloned and expressed in Escherichia coli. The catalytic activities... on kinetic parameters and inhibitory constant suggest that the wild-type P. vivax is susceptible to antimalarial antifolates and that point mutations in the DHFR domain of P. vivax are responsible for antifolate resistance. © 2002 Elsevier Science B.V. All
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    A trade off between catalytic activity and protein stability determines the clinical manifestations of glucose-6-phosphate dehydrogenase (G6PD) deficiency
    (2017-11-01) Usa Boonyuen; Kamonwan Chamchoy; Thitiluck Swangsri; Thanyaphorn Junkree; Nicholas P.J. Day; Nicholas J. White; Mallika Imwong; Mahidol University; Nuffield Department of Clinical Medicine
    © 2017 The Authors Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common polymorphism and enzymopathy in humans, affecting approximately 400 million people worldwide. It is responsible for various clinical manifestations, including
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    Genetic population of Plasmodium knowlesi during pre-malaria elimination in Thailand
    (2021-12-01) Rungniran Sugaram; Patcharida Boondej; Suttipat Srisutham; Chanon Kunasol; Watcharee Pagornrat; Usa Boonyuen; Arjen M. Dondorp; Aungkana Saejeng; Prayuth Sudathip; Mallika Imwong; Faculty of Tropical Medicine, Mahidol University; Chulalongkorn University; Thailand Ministry of Public Health; Nuffield Department of Medicine
    that can also infect humans, have been increasingly observed. This study focused on the molecular analysis of P. knowlesi parasites causing malaria in Thailand. Methods: Under Thailand’s integrated Drug Efficacy Surveillance (iDES), which includes drug...-resistance monitoring as part of routine case-based surveillance and responses, specimens were collected from malaria patients (n = 966) between 2018 and 2020. Thirty-one mono P. knowlesi infections (3.1%), most of which were from eastern and southern
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    Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing
    (2012-07-19) Magnus Manske; Olivo Miotto; Susana Campino; Sarah Auburn; Jacob Almagro-Garcia; Gareth Maslen; Jack O'Brien; Abdoulaye Djimde; Ogobara Doumbo; Issaka Zongo; Jean Bosco Ouedraogo; Pascal Michon; Ivo Mueller; Peter Siba; Alexis Nzila; Steffen Borrmann; Steven M. Kiara; Kevin Marsh; Hongying Jiang; Xin Zhuan Su; Chanaki Amaratunga; Rick Fairhurst; Duong Socheat; Francois Nosten; Mallika Imwong; Nicholas J. White; Mandy Sanders; Elisa Anastasi; Dan Alcock; Eleanor Drury; Samuel Oyola; Michael A. Quail; Daniel J. Turner; Valentin Ruano-Rubio; Dushyanth Jyothi; Lucas Amenga-Etego; Christina Hubbart; Anna Jeffreys; Kate Rowlands; Colin Sutherland; Cally Roper; Valentina Mangano; David Modiano; John C. Tan; Michael T. Ferdig; Alfred Amambua-Ngwa; David J. Conway; Shannon Takala-Harrison; Christopher V. Plowe; Julian C. Rayner; Kirk A. Rockett; Taane G. Clark; Chris I. Newbold; Matthew Berriman; Bronwyn MacInnis; Dominic P. Kwiatkowski; Wellcome Trust Sanger Institute; University of Oxford; Mahidol University; Menzies School of Health Research; Wellcome Trust Centre for Human Genetics; University of Bamako Faculty of Medicine, Pharmacy and Odonto-Stomatology; Institut de Recherche en Sciences de la Santé; Papua New Guinea Institute of Medical Research; Wellcome Trust Research Laboratories Nairobi; National Institute of Allergy and Infectious Diseases; Cambodia National Malaria Centre; Shoklo Malaria Research Unit; Navrongo Health Centre; London School of Hygiene & Tropical Medicine; Universita degli Studi di Roma La Sapienza; University of Notre Dame; Medical Research Council Laboratories Gambia; University of Maryland, Baltimore; Weatherall Institute of Molecular Medicine
    Malaria elimination strategies require surveillance of the parasite population for genetic changes that demand a public health response, such as new forms of drug resistance. Here we describe methods for the large-scale analysis of genetic variation
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    Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria.
    (2014-12-09) White, Nicholas J; Ashley, Elizabeth A; Recht, Judith; Delves, Michael J; Ruecker, Andrea; Smithuis, Frank M; Eziefula, Alice C; Bousema, Teun; Drakeley, Chris; Kesinee Chotivanich; เกศินี โชติวานิช; Mallika Imwong; มัลลิกา อิ่มวงศ์; Sasithon Pukrittayakamee; ศศิธร ผู้กฤตยาคามี; Jetsumon Prachumsri; เจตสุมน ประจำศรี; Chu, Cindy; Andolina, Chiara; Bancone, Germana; Hien, Tran T; Mayxay, Mayfong; Taylor, Walter RJ; Seidlein, Lorenz von; Price, Ric N; Barnes, Karen I; Djimdé, Abdoulaye; ter Kuile, Feiko; Gosling, Roly; Chen, Ingrid; Dhorda, Mehul J; Stepniewska, Kasia; Guérin, Philippe; Woodrow, Charles J; Dondorp, Arjen M; Day, Nicholas PJ; Nosten, Francois H; White, Nicholas J; Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicine.; Mahidol University. Faculty of Tropical Medicine. Department of Molecular Tropical Medicine and Genetics.; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit.; Mahidol University. Faculty of Tropical Medicine. Mahidol Vivax Research Unit.; Mahidol University. Faculty of Tropical Medicine. Shoklo Malaria Research Unit.
    (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas
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    Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia.
    (2013-01-02) Takala-Harrisona, Shannon; Clark, Taane G.; Cummings, Michael P.; Miotto,Olivo; Dondorp, Arjen M.; Fukudaf, Mark M.; Nosten, Francois; Noedl, Harald; Mallika Imwong; มัลลิกา อิ่มวงศ์; Bethell, Delia; Se, Youry; Lon, Chanthap; Tyner, Stuart D.; Saunders, David L.; Socheat, Duong; Ariey, Frederic; Phyo, Aung Pyae; Starzengruber, Peter; Fuehrer, Hans-Peter; Swoboda, Paul; Stepniewska, Kasia; Flegg, Jennifer; Arze, Cesar; Cerqueira, Gustavo C.; Silva, Joana C.; Ricklefs, Stacy M.; Porcella, Stephen F.; Stephens, Robert M.; Adams, Matthew; Kenefic, Leo J.; Campino, Susana; Auburn, Sarah; MacInnis, Bronwyn; Kwiatkowski, Dominic P.; Su, Xin-zhuan; White, Nicholas J.; Ringwald, Pascal; Plowe, Christopher V.; Plowe, Christopher V.; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Research Unit.; Mahidol University. Faculty of Tropical Medicine. Department of Molecular Tropical Medicine and Genetics.; Mahidol University. Faculty of Tropical Medicine. Shoklo Malaria Research Unit.
    responsible for artemisinin resistance and to understand the mechanism behind it; however, two SNPs on chromosomes 10 and 13 may be useful markers of delayed parasite clearance in surveillance for artemisinin resistance in Southeast Asia.
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    PublicationOpen Access
    Practical PCR genotyping protocols for Plasmodium vivax using Pvcs and Pvmsp1.
    (2005-04-27) Mallika Imwong; มัลลิกา อิ่มวงศ์; Sasithon Pukrittayakamee; Grüner, Anne Charlotte; Rénia, Laurent; Letourneur, Frank; Sornchai Looareesuwan; ศรชัย หลูอารีย์สุวรรณ; White, Nicholas J.; Snounou, Georges; Mallika Imwong; Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicine.
    and parasitological responses. In both groups, the PCR adjusted cure rates by day 42 were high: 98.8% (95% CI 96.4, 99.6%) for artemether-lumefantrine and 96.3% (95% CI 93.1, 98.0%) for artesunate-mefloquine. Both regimens were very well tolerated with no serious... adverse events observed attributable to either combination. CONCLUSION: Overall, this study confirms that these two artemisinin-based combinations remain highly effective and result in equivalent therapeutic responses in the treatment of highly drug