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Publication Metadata only Clinical epidemiology and outcomes of community acquired infection and sepsis among hospitalized patients in a resource limited setting in Northeast Thailand: A prospective observational study (Ubon-sepsis)(2018-09-01) Viriya Hantrakun; Ranjani Somayaji; Prapit Teparrukkul; Chaiyaporn Boonsri; Kristina Rudd; Nicholas P.J. Day; Eoin E. West; Direk Limmathurotsakul; University of Washington, Seattle; Mahidol University; Nuffield Department of Clinical Medicine; Sunpasitthiprasong Hospitalthe clinical epidemiology and outcomes of adults admitted with community-acquired infection in a resource-limited tertiary-care hospital in Ubon Ratchathani province, Northeast Thailand. Hospitalized patients with infection and accompanying systemic... NCT02217592. A total of 4,989 patients were analyzed. Of the cohort, 2,659 (53%) were male and the median age was 57 years (range 18–101). Of these, 1,173 (24%) patients presented primarily to the study hospital, 3,524 (71%) were transferred from 25Publication Metadata only Doxycycline versus azithromycin for treatment of leptospirosis and scrub typhus(2007-09-01) Kriangsak Phimda; Siriwan Hoontrakul; Chuanpit Suttinont; Sompong Chareonwat; Kitti Losuwanaluk; Sunee Chueasuwanchai; Wirongrong Chierakul; Duangjai Suwancharoen; Saowaluk Silpasakorn; Watcharee Saisongkorh; Sharon J. Peacock; Nicholas P.J. Day; Yupin Suputtamongkol; Udonthani Hospital; Chumphon Hospital; Maharaj Nakhon Ratchasima Hospital; Chaiyapoom Hospital; Banmai Chaiyapod Hospital; Mahidol University; Thailand Ministry of Agriculture and Cooperatives; Thailand Ministry of Public Health, randomized controlled trial with adult patients presenting with acute fever (< 15 days), without an obvious focus of infection, at four hospitals in Thailand between July 2003 and January 2005. Patients were randomly allocated to receive either a 7-day course... of doxycycline or a 3-day course of azithromycin. The cure rate, fever clearance time, and adverse drug events were compared between the two study groups. A total of 296 patients were enrolled in the study. The cause of acute fever was determined for 151 patientsPublication Metadata only A randomized controlled trial of granulocyte colony-stimulating factor for the treatment of severe sepsis due to melioidosis in Thailand(2007-08-01) Allen C. Cheng; Direk Limmathurotsakul; Wirongrong Chierakul; Nongluk Getchalarat; Vanaporn Wuthiekanun; Dianne P. Stephens; Nicholas P.J. Day; Nicholas J. White; Wipada Chaowagul; Bart J. Currie; Sharon J. Peacock; Menzies School of Health Research; Royal Darwin Hospital; Mahidol University; Sappasitthiprasong Hospital; John Radcliffe Hospital; University of Melbourneof lenograstim (granulocyte colony-stimulating factor [G-CSF], 263 μg per day administered intravenously) in ceftazidime-treated patients with severe sepsis caused by suspected melioidosis in Thailand. Results. Over a 27-month period, 60 patients were enrolled... to receive either G-CSF (30 patients, 18 of whom had culture-confirmed melioidosis) or placebo (30 patients, 23 of whom had culture-confirmed melioidosis). Mortality rates were similar in both groups (G-CSF group, 70%; placebo group, 87%; risk ratio, 0.81; 95Publication Metadata only A prospective study of the importance of enteric fever as a cause of non-malarial febrile illness in patients admitted to Chittagong Medical College Hospital, Bangladesh(2016-10-13) Rapeephan R. Maude; Aniruddha Ghose; Rasheda Samad; Hanna K. de Jong; Masako Fukushima; Lalith Wijedoru; Mahtab Uddin Hassan; Md Amir Hossain; Md Rezaul Karim; Abdullah Abu Sayeed; Stannie van den Ende; Sujat Pal; A. S.M. Zahed; Wahid Rahman; Rifat Karnain; Rezina Islam; Dung Thi Ngoc Tran; Tuyen Thanh Ha; Anh Hong Pham; James I. Campbell; H. Rogier van Doorn; Richard J. Maude; Tom van der Poll; W. Joost Wiersinga; Nicholas P.J. Day; Stephen Baker; Arjen M. Dondorp; Christopher M. Parry; Md Abul Faiz; Mahidol University; Chittagong Medical College Hospital; Academic Medical Centre, University of Amsterdam; Liverpool School of Tropical Medicine; UCL; Nuffield Department of Clinical Medicine; London School of Hygiene & Tropical Medicine; Nagasaki University; Dev Care Foundationin 34 (11.3 %) of patients. Of note Rickettsia typhi and Orientia tsutsugamushi were detected by PCR in two and one patient respectively. Twenty-nine (9 %) patients died during their hospital admission (15/160 (9.4 %) of children and 14/144 (9...© 2016 The Author(s). Background: Fever is a common cause of hospital admission in Bangladesh but causative agents, other than malaria, are not routinely investigated. Enteric fever is thought to be common. Methods: Adults and children admittedPublication Metadata only Effectiveness of a sepsis programme in a resource-limited setting: A retrospective analysis of data of a prospective observational study (Ubon-sepsis)(2021-02-18) Suchart Booraphun; Viriya Hantrakun; Suwatthiya Siriboon; Chaiyaporn Boonsri; Pulyamon Poomthong; Bung Orn Singkaew; Oratai Wasombat; Parinya Chamnan; Ratapum Champunot; Kristina Rudd; Nicholas P.J. Day; Arjen M. Dondorp; Prapit Teparrukkul; Timothy Eoin West; DIrek Limmathurotsakul; Faculty of Tropical Medicine, Mahidol University; University of Washington; Nuffield Department of Medicine; University of Pittsburgh School of Medicine; Sunpasitthiprasong Hospital; Buddhachinaraj Phitsanulok Hospital) from March 2013 to January 2017. Setting General medical wards and medical intensive care units (ICUs) of a study hospital. Participants Patients with community-acquired sepsis observed under the Ubon-sepsis cohort. Sepsis was defined as modified... Sequential Organ Failure Assessment (SOFA) Score ≥2. Main exposure The SFT programme was a protocol to identify and initiate sepsis care on hospital admission, implemented at the study hospital in 2015. Patients in the SFT programme were admitted directlyPublication Metadata only Early management of sepsis in medical patients in rural Thailand: A single-center prospective observational study(2019-12-02) Kristina E. Rudd; Viriya Hantrakun; Ranjani Somayaji; Suchart Booraphun; Chaiyaporn Boonsri; Annette L. Fitzpatrick; Nicholas P.J. Day; Prapit Teparrukkul; Direk Limmathurotsakul; T. Eoin West; University of Pittsburgh; University of Washington, Seattle; Mahidol University; Nuffield Department of Clinical Medicine; University of Calgary; Sunpasitthiprasong Hospitalwith community-acquired sepsis. Results: Between March 2013 and January 2017, 3,716 patients with sepsis were enrolled. The median age was 59 years (IQR 44-72, range 18-101), 58% were male, and 88% were transferred from other hospitals. Eighty-six percent...,308) received antibiotics within the first day of hospital admission. Among the 3,089 patients admitted to the general medical wards, 38% (N = 1,165) received an adrenergic agent, and 21% (N = 650) received invasive mechanical ventilation. Overall mortalityPublication Metadata only Point-of-care lung ultrasound for the detection of pulmonary manifestations of malaria and sepsis: An observational study(2018-12-01) Stije J. Leopold; Aniruddha Ghose; Katherine A. Plewes; Subash Mazumder; Luigi Pisani; Hugh W.F. Kingston; Sujat Paul; Anupam Barua; M. Abdus Sattar; Michaëla A.M. Huson; Andrew P. Walden; Patricia C. Henwood; Elisabeth D. Riviello; Marcus J. Schultz; Nicholas P.J. Day; Asok Kumar Dutta; Nicholas J. White; Arjen M. Dondorp; Brigham and Women's Hospital; Mahidol University; Chittagong Medical College Hospital; Nuffield Department of Clinical Medicine; Royal Berkshire Hospital; Harvard Medical School; Amsterdam UMC - University of Amsterdam-constrained hospital setting. LUS was highly feasible and allowed to accurately identify patients at risk of death in a resource limited setting.... are credited. Introduction Patients with severe malaria or sepsis are at risk of developing life-threatening acute respiratory distress syndrome (ARDS). The objective of this study was to evaluate point-of-care lung ultrasound as a novel tool to determinePublication Metadata only Comparative clinical characteristics and outcomes of patients with community acquired bacteremia caused by escherichia coli, burkholderia pseudomallei and staphylococcus aureus: A prospective observational study (ubon-sepsis)(2021-09-01) Ranjani Somayaji; Viriya Hantrakun; Prapit Teparrukkul; Gumphol Wongsuvan; Kristina E. Rudd; Nicholas P.J. Day; T. Eoin West; Direk Limmathurotsakul; Faculty of Tropical Medicine, Mahidol University; University of Washington; Nuffield Department of Medicine; University of Calgary; University of Pittsburgh School of Medicine; Sunpasitthiprasong Hospitalobservational study (Ubon-sepsis) of adults admitted to a referral hospital with community-acquired infection in Northeastern Thailand was conducted between March 1, 2013 and February 1, 2017. In the present analysis, patients with a blood culture collected... sepsis, 155, 131 and 37 patients had a blood culture positive for Escherichia coli, Burkholderia pseudo-mallei and Staphylococcus aureus, respectively. Of these 323 CAB patients, 284 (89%) were transferred from other hospitals. 28-day mortalityPublication Metadata only Long-term survival after intensive care unit discharge in Thailand: A retrospective study(2013-10-03) Nantasit Luangasanatip; Maliwan Hongsuwan; Yoel Lubell; Direk Limmathurotsakul; Prapit Teparrukkul; Sirirat Chaowarat; Nicholas P.J. Day; Nicholas Graves; Ben S. Cooper; Mahidol University; Queensland University of Technology QUT; Nuffield Department of Clinical Medicine; Sappasitthiprasong HospitalIntroduction: Economic evaluations of interventions in the hospital setting often rely on the estimated long-term impact on patient survival. Estimates of mortality rates and long-term outcomes among patients discharged alive from the intensive care... from a regional tertiary hospital in northeast Thailand and the regional death registry were linked and used to assess patient survival time after ICU discharge. Adult ICU patients aged at least 15 years who had been discharged alive from an ICU betweenPublication Metadata only Clinical Characteristics and Outcome of Children Hospitalized With Scrub Typhus in an Area of Endemicity(2020-04-30) Tri Wangrangsimakul; Rachel C. Greer; Chulapong Chanta; Supalert Nedsuwan; Stuart D. Blacksell; Nicholas P.J. Day; Daniel H. Paris; Universitat Basel; Mahidol University; Nuffield Department of Clinical Medicine; Chiangrai Prachanukroh Hospitalin the rural tropics. METHODS: We recruited 60 febrile pediatric patients with a positive scrub typhus rapid diagnostic test result and 40 healthy controls from Chiang Rai Province in northern Thailand. Diagnosis was confirmed by the detection of (1) O...:3200 in an acute plasma sample with an IFA. Demographic, clinical, and laboratory data were collected, and patients were followed up for 1 year. RESULTS: Diagnosis was confirmed in 35 (58%) of 60 patients, and all controls tested negative for scrub