3 results
Search Results
Now showing 1 - 3 of 3
Publication Metadata only The integrity of the FOG-2 LXCXE pRb-binding motif is required for small intestine homeostasis(2019-07-01) Olivier Goupille; Zahra Kadri; Amandine Langelé; Sophie Luccantoni; Cécile Badoual; Philippe Leboulch; Stany Chrétien; Hopital Europeen Georges-Pompidou; Université Paris-Sud; Brigham and Women's Hospital; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Inserm© 2019 The Authors. Experimental Physiology © 2019 The Physiological Society New Findings: What is the central question of this study? Do Fog2Rb−/Rb− mice present a defect of small intestine homeostasis? What is the main finding and its importance...? The importance of interactions between FOG-2 and pRb in adipose tissue physiology has previously been demonstrated. Here it is shown that this interaction is also intrinsic to small intestine homeostasis and exerts extrinsic control over mouse metabolism. ThusPublication Metadata only The LXCXE Retinoblastoma Protein-Binding Motif of FOG-2 Regulates Adipogenesis(2017-12-19) Olivier Goupille; Tipparat Penglong; Zahra Kadri; Marine Granger-Locatelli; Raphaël Denis; Serge Luquet; Cécile Badoual; Suthat Fucharoen; Leila Maouche-Chrétien; Philippe Leboulch; Stany Chrétien; Universite Paris-Saclay; Mahidol University; Universite Paris 7- Denis Diderot; Hopital Europeen Georges-Pompidou; Inserm; Brigham and Women's Hospital and Harvard Medical School© 2017 The Author(s) GATA transcription factors and their FOG cofactors play a key role in tissue-specific development and differentiation, from worms to humans. Mammals have six GATA and two FOG factors. We recently demonstrated that interactions... between retinoblastoma protein (pRb) and GATA-1 are crucial for erythroid proliferation and differentiation. We show here that the LXCXE pRb-binding site of FOG-2 is involved in adipogenesis. Unlike GATA-1, which inhibits cell division, FOG-2 promotesPublication Metadata only Erythropoietin and IGF-1 signaling synchronize cell proliferation and maturation during erythropoiesis(2015-12-15) Zahra Kadri; Carine Lefevre; Olivier Goupille; Tipparat Penglong; Marine Granger-Locatelli; Suthat Fucharoen; Leila Maouche-Chretien; Philippe Leboulch; Stany Chretien; Institut des Maladies Emergentes et des Therapies Innovantes; Universite Paris-Saclay; Mahidol University; Inserm; Brigham and Women's Hospital© 2015 Kadri et al. Tight coordination of cell proliferation and differentiation is central to red blood cell formation. Erythropoietin controls the proliferation and survival of red blood cell precursors, while variations in GATA-1/FOG-1 complex... for FOG-1. In turn, FOG-1 displaces pRb/E2F-2 fromGATA-1, ultimately releasing free, proproliferative E2F-2. Mice bearing a Gata-1S310Amutation suffer fromfatal anemia when a compensatory pathway for E2F-2 production involving insulin-like growth factor-1