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Publication Metadata only Short report: Electrocardiographic safety evaluation of dihydroartemisinin-piperaquine in the treatment of uncomplicated falciparum malaria(2007-09-01) Oliver T. Mytton; Elizabeth A. Ashley; Leon Peto; Ric N. Price; Yar La; Rae Hae; Pratap Singhasivanon; Nicholas J. White; François Nosten; Shoklo Malaria Research Unit; Mahidol University; Churchill Hospital; Menzies School of Health Research; Epicentre, respectively. These small changes on the third day of treatment are similar to those observed elsewhere in the convalescent phase following antimalarial treatment with drugs known to have no cardiac effects and are therefore likely to result from recovery from... acute malaria and not the treatment given. At therapeutic doses, DP does not have clinically significant effects on the electrocardiogram. Copyright © 2007 by The American Society of Tropical Medicine and Hygiene.Publication Metadata only Missed appointments at a tuberculosis clinic increased the risk of clinical treatment failure(2006-03-01) Sompong Srisaenpang; Somdej Pinitsoontorn; Pratap Singhasivanon; Dwip Kitayaporn; Jaranit Kaewkungwal; Pyatat Tatsanavivat; Boonsong Patjanasoontorn; Wipa Reechaipichitkul; Jammari Thiratakulpisan; Jiraporn Srinakarin; Prasopsuk Srisaenpang; Bandit Thinkamrop; Chalermchai Apinyanurak; Bung Onsee Chindawong; Khon Kaen University; Mahidol UniversityWe investigated the charts of 381 new smear-positive tuberculosis patients at Khon Kaen Medical School during 1997-2001 using World Health Organization definitions to evaluate associations among treatment success or failure (defaulted, failed, died..., or not evaluated) and tuberculosis clinic contact, demographics and clinical characteristics of the patients. Multinomial logistic regression was used for three-category outcome analysis: treatment success, transferred-out and clinical treatment failurePublication Metadata only A case-control auditory evaluation of patients treated with artemether-lumefantrine(2006-02-01) Robert Hutagalung; Hsar Htoo; Paw Nwee; Jaruwan Arunkamomkiri; Julien Zwang; Verena I. Carrara; Elizabeth Ashley; Pratap Singhasivanon; Nicholas J. White; François Nosten; Shoklo Malaria Research Unit; Churchill Hospital; Mahidol UniversityArtemether-lumefantrine is the first registered, fixed, artemisinin-based combination treatment. Artemisinin derivatives are highly effective antimalarials with a favorable safety profile. Concerns remain over their potential neurotoxicity, althoughPublication Metadata only Population pharmacokinetic and pharmacodynamic modeling of amodiaquine and desethylamodiaquine in women with Plasmodium vivax Malaria during and after pregnancy(2012-11-01) Joel Tarning; Palang Chotsiri; Vincent Jullien; Marcus J. Rijken; Martin Bergstrand; Mireille Cammas; Rose McGready; Pratap Singhasivanon; Nicholas P J Day; Nicholas J. White; Francois Nosten; Niklas Lindegardh; Mahidol University; Nuffield Department of Clinical Medicine; Universite Paris Descartes; Shoklo Malaria Research Unit; Uppsala UniversitetAmodiaquine is effective for the treatment of Plasmodium vivax malaria, but there is little information on the pharmacokinetic and pharmacodynamic properties of amodiaquine in pregnant women with malaria. This study evaluated the population... to evaluate the population pharmacokinetic and pharmacodynamic properties of amodiaquine and desethylamodiaquine. Amodiaquine plasma concentrations were described accurately by lagged first-order absorption with a two-compartment disposition model followedPublication Metadata only Effects of different antimalarial drugs on gametocyte carriage in P. vivax malaria(2008-09-01) Sasithon Pukrittayakamee; Mallika Imwong; Pratap Singhasivanon; Kasia Stepniewska; Nicholas J. Day; Nicholas J. White; Mahidol UniversityThe gametocytocidal and asexual stage activities of eight antimalarial and eight antibiotic-containing regimens were evaluated in 349 adult patients with P. vivax malaria. Gametocytemia was found in 63% of patients (22% before and 41% afterPublication Metadata only An open-label crossover study to evaluate potential pharmacokinetic interactions between oral oseltamivir and intravenous zanamivir in healthy thai adults(2011-09-01) Sasithon Pukrittayakamee; Podjanee Jittamala; Kasia Stepniewska; Niklas Lindegardh; Sunee Chueasuwanchai; Wattana Leowattana; Aphiradee Phakdeeraj; Sutatip Permpunpanich; Warunee Hanpithakpong; Wirichada Pan-Ngum; Caroline Fukuda; Salwaluk Panapipat; Pratap Singhasivanon; Nicholas J. White; Nicholas P J Day; Mahidol University; Churchill HospitalThere is no parenteral formulation of the neuraminidase inhibitor oseltamivir, the most widely used anti-influenza virus drug. Oseltamivir resistance is an increasing problem. Zanamivir is effective against the most prevalent oseltamivir-resistantPublication Metadata only A small amount of fat does not affect piperaquine exposure in patients with malaria(2011-09-01) Anna Annerberg; Khin Maung Lwin; Niklas Lindegardh; Sakchai Khrutsawadchai; Elizabeth Ashley; Nicholas P.J. Day; Pratap Singhasivanon; Joel Tarning; Nicholas J. White; François Nosten; Mahidol University; Nuffield Department of Clinical Medicine; Shoklo Malaria Research Unitthe oral bioavailability of the drug, and this has been reported for healthy volunteers. This pharmacokinetic study monitored 30 adult patients with uncomplicated falciparum malaria for 4.5 months to evaluate the effects of the concomitant intake of fat...Dihydroartemisinin-piperaquine is a new, highly effective, and well-Tolerated combination treatment for uncomplicated falciparum malaria. The lipophilic characteristic of piperaquine suggests that administration together with fat will increasePublication Metadata only Spatiotemporal Bayesian networks for malaria prediction(2018-01-01) Peter Haddawy; A. H.M.Imrul Hasan; Rangwan Kasantikul; Saranath Lawpoolsri; Patiwat Sa-angchai; Jaranit Kaewkungwal; Pratap Singhasivanon; Mahidol University© 2017 Elsevier B.V. Targeted intervention and resource allocation are essential for effective malaria control, particularly in remote areas, with predictive models providing important information for decision making. While a diversity of modeling... and environmental covariates. Three types of networks are explored: networks for numeric prediction, networks for outbreak prediction, and networks that incorporate spatial autocorrelation. Evaluation of the numeric prediction network shows that the Bayes net hasPublication Metadata only Malaria education from school to community in Oudomxay province, Lao PDR(2008-03-01) Daisuke Nonaka; Jun Kobayashi; Masamine Jimba; Bounsou Vilaysouk; Katsuyuki Tsukamoto; Shigeyuki Kano; Bounlay Phommasack; Pratap Singhasivanon; Jitra Waikagul; Seiki Tateno; Tsutomu Takeuchi; University of Tokyo; National Center for Global Health and Medicine; Mahidol University; Oudomxay Provincial Health Office; Ministry of Health; Keio UniversitySchool-based malaria education has been shown to be effective for improving the knowledge, attitudes, and practices of school children toward malaria control. However, little has been reported about the effect of such education on communities... in developing countries. To evaluate the influence of school-based malaria education on the knowledge, attitudes, and practices of people in the community toward malaria, we conducted a school-based intervention in Oudomxay province, Lao PDR, and compared scoresPublication Metadata only Auditory assessment of patients with acute uncomplicated Plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north-western border of Thailand(2008-12-08) Verena I. Carrara; Aung P. Phyo; Paw Nwee; Ma Soe; Hsar Htoo; Jaruwan Arunkamomkiri; Pratap Singhasivanon; François Nosten; Shoklo Malaria Research Unit; Mahidol University; Churchill HospitalBackground. The use of artemisinin derivatives has increased exponentially with the deployment of artemisinin combination therapy (ACT) in all malarious areas. They are highly effective and are considered safe, but in animal studies artemisinin... derivatives produce neurotoxicity targeting mainly the auditory and vestibular pathways. The debate remains as to whether artemisinin derivatives induce similar toxicity in humans. Methods. This prospective study assessed the effects on auditory function of a