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Publication Metadata only Edaravone, a synthetic free radical scavenger, enhances alteplase-mediated thrombolysis(2017-01-01) Kiyoshi Kikuchi; Kentaro Setoyama; Ko Ichi Kawahara; Tomoka Nagasato; Takuto Terashi; Koki Ueda; Kazuki Nakanishi; Shotaro Otsuka; Naoki Miura; Hisayo Sameshima; Kazuya Hosokawa; Yoichiro Harada; Binita Shrestha; Mika Yamamoto; Yoko Morimoto-Yamashita; Haruna Kikuchi; Ryoji Kiyama; Chinatsu Kamikokuryo; Salunya Tancharoen; Harutoshi Sakakima; Motohiro Morioka; Eiichiro Tanaka; Takashi Ito; Ikuro Maruyama; Kurume University School of Medicine; Kagoshima University; Mahidol University; Osaka Institute of Technology; Fujimori Kogyo Co.on the thrombolytic efficacy of alteplase by measuring thrombolysis using a newly developed microchip-based flow-chamber assay. Rat models of embolic cerebral ischemia were treated with either alteplase or alteplase-edaravone combination therapy. The combination... therapy significantly reduced the infarct volume and improved neurological deficits. Human blood samples from healthy volunteers were exposed to edaravone, alteplase, or a combination of alteplase and edaravone or hydrogen peroxide. Whole bloodPublication Metadata only Uric acid enhances alteplase-mediated thrombolysis as an antioxidant(2018-12-01) Kiyoshi Kikuchi; Kentaro Setoyama; Eiichiro Tanaka; Shotaro Otsuka; Takuto Terashi; Kazuki Nakanishi; Seiya Takada; Harutoshi Sakakima; Sumate Ampawong; Ko ichi Kawahara; Tomoka Nagasato; Kazuya Hosokawa; Yoichiro Harada; Mika Yamamoto; Chinatsu Kamikokuryo; Ryoji Kiyama; Motohiro Morioka; Takashi Ito; Ikuro Maruyama; Salunya Tancharoen; Osaka Institute of Technology; Kagoshima University; Mahidol University; Kurume University School of Medicine; Fujimori Kogyo Co.© 2018, The Author(s). Uric acid (UA) therapy may prevent early ischemic worsening after acute stroke in thrombolysis patients. The aim of this study was to examine the influence of UA on the thrombolytic efficacy of alteplase in human blood samples... significantly inhibited the effect of hydrogen peroxide. Meanwhile, rat models of thromboembolic cerebral ischemia were treated with either alteplase or UA–alteplase combination therapy. Compared with alteplase alone, the combination therapy reduced the infarctPublication Metadata only A comparative study of the cytotoxic activities of three plants: Curcuma zedoaria, pinus maritima and curcuma xanthorrhiza on skin cancer A375 and HSC-5 cell lines(2018-06-08) Sunisa Thaichinda; Thamthiwat Nararatwanchai; Salunya Tancharoen; Takuro Kanekura; Yuko Higashi; Mae Fah Luang University; Kagoshima University Faculty of Medicine; Mahidol University© 2018 IEEE. Background-Nowadays much attention has been focus on the use of natural plant-derived therapies. The three kinds of Thai plants, Curcuma zedoaria (CZ), Pinus maritima (PM) and Curcuma xanthorrrhiza (CX) have been reported to have many... and squamous cell carcinoma HSC-5 cell line after their supplementation by detection of intracellular ROS using CM-H2DCFDA as the fluorescent probe. Results-We found that only PM significantly induced oxidative stress responses in term of ROS generation on bothPublication Metadata only Nucleophosmin may act as an alarmin: Implications for severe sepsis(2009-09-01) Yuko Nawa; Ko Ichi Kawahara; Salunya Tancharoen; Xiaojie Meng; Hisayo Sameshima; Takashi Ito; Yoshiki Masuda; Hitoshi Imaizumi; Teruto Hashiguchi; Ikuro Maruyama; Kagoshima University Faculty of Medicine; Mahidol University; Sapporo Medical University School of MedicineNPM is a major nucleolar multifunctional protein involved in ribosome biogenesis, centrosome duplication, cell-cycle progression, apoptosis, cell differentiation, and sensing cellular stress. Alarmins are endogenous molecules released from activated....7 cells. Our data indicate that NPM may have potent biological activities that contribute to systemic inflammation. Further investigations of the role of NPM may lead to new therapies for patients with septic shock or other inflammatory diseases. © SocietyPublication Open Access The efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease.(2013-07) Kikuchi, Kiyoshi; Salunya Tancharoen; ศรัณยา ตันเจริญ; Takeshige, Nobuyuki; Yoshitomi, Munetake; Morioka, Motohiro; Murai, Yoshinaka; Tanaka, Eiichiro; Mahidol University. Faculty of Dentistry. Department of Pharmacologyinfarction. Edaravone may represent a new therapeutic intervention for endothelial dysfunction in the setting of atherosclerosis, heart failure, diabetes, or hypertension, because these diseases result from oxidative stress and/or cytokine-induced apoptosisPublication Open Access Potential of the angiotensin receptor blockers (ARBs) telmisartan, irbesartan, and candesartan for inhibiting the HMGB1/RAGE axis in prevention and acute treatment of stroke.(2013-09) Salunya Tancharoen; ศรัณยา ตันเจริญ; Kikuchi, Kiyoshi; Ito, Takashi; Morimoto-Yamashita, Yoko; Miura, Naoki; Kawahara, Ko-ichi; Maruyama, Ikuro; Murai, Yoshinaka; Tanaka, Eiichiro; Tanaka, Eiichiro; Mahidol University. Faculty of Dentistry. Department of Pharmacology-RAGE axis on stroke therapy, including prevention and acute treatment. This review covers clinical and experimental studies conducted between 1976 and 2013. We propose that ARBs, which inhibit the HMGB1/RAGE axis, may offer a novel option for preventionPublication Open Access Secondhand smoke exposure-induced nucleocytoplasmic shuttling of HMGB1 in a rat premature skin aging model.(2014-11-21) Salunya Tancharoen; ศรัณยา ตันเจริญ; Pornpen Dararat; พรเพ็ญ ดารารัตน์; Somphong Narkpinit; สมพงษ์ นาคพินิจ; Kikuchi, Kiyoshi; Sirintip Chaichalotornkul; สิรินทิพย์ ชัยชโลทรกุล; Thamthiwat Nararatwanchai; Maruyama, Ikuro; Mahidol University. Faculty of Dentistry. Department of Pharmacology; Mahidol University. Faculty of Science. Department of PathobiologySecondhand cigarette smoke exposure (SSE) has been linked to carcinogenic, oxidative, and inflammatory reactions. Herein, we investigated whether premature skin aging could be induced by SSE in a rat model, and assessed the cytoplasmic translocation of high mobility group box 1 (HMGB1) protein and collagen loss in skin tissues. Animals were divided into two groups: SSE and controls. Whole body SSE was carried out for 12 weeks. Dorsal skin tissue specimens were harvested for HMGB1 and Mallory’s azan staining. Correlations between serum HMGB1 and collagen levels were determined. Rat skin exposed to secondhand smoke lost collagen bundles in the papillary dermis and collagen decreased significantly (p < 0.05) compared with control rats. In epidermal keratinocytes, cytoplasmic HMGB1 staining was more diffuse and there were more HMGB1-positive cells after four weeks in SSE compared to control rats. A negative correlation between HMGB1 serum and collagen levels (r = −0.631, p = 0.28) was also observed. Therefore, cytoplasmic HMGB1 expression in skin tissues might be associated with skin collagen loss upon the initiation of SSE. Additionally, long-term SSE might affect the appearance of the skin, or could accelerate the skin aging process.