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Item Open Access Development of in-vitro methods to detect neutralizing antibody against the light chain of botulinum toxin in secondary botulinum toxin treatment failure patients(Mahidol University Library and Knowledge Center, 2021) Ishwor Sharma; Yuttana Srinoulprasert; Duangjit Kanistanon; Rungsima Wanitphakdeedechahad never undergone BoNT/A treatment. The BoNT/A tolerant group consisted of four stable individuals who had undergone BoNT/A treatment but were unable to respond. Only the patients with frontalis test positive were recruited into this study. The level...: This study would help us establish a non-cellular in-vitro immunological technique for detecting NAbs against the light chain of BoNT/A in STF patients in routine clinical practice and providing a rapid diagnosis. Furthermore, it has the potentialItem Metadata only Development of peptide inhibitors against dengue virus infection by in silico desigh and in vitro studies(Mahidol University. Mahidol University Library and Knowledge Center, 2023) Aussara Panya; Pa-thai Yenchitsomanus; Chatchawan Srisawat; Mutita Junking; Kiattewee Choowongkomon. The designed peptides were tested for cytotoxicity to host cell, and its inhibitory effect on DENV foci formation in Vero cells. The peptide effects were further charaterized on the reduction of DENV genome, protein, and infectivity levels by using real-time... PCR, cell-based flavivirus immunodetection and immunofluorence assay. Finally, the peptide inhibitory effect was tested with all four DENV serotypes (DENV1, DENV2, DENV3, and DENV4) in an effort to study the cross-serotype antiviral activity. Using aItem Open Access A pathogenesis study related to the biofilm formation by candida albicans isolated from hemoculture using the zebrafish model of infection(Mahidol University. Mahidol University Library and Knowledge Center, 2022) Pokhrel, Sabi, 1991-; Popchai Ngamskulrungroj; Iyarit Thaipisutikul; Phoom Chairatana; Chalermchai Mitrpant- biofilm forming C. albicans strains. However, there was no statistical difference in colony forming unit tissue burden among groups of all three tested strains. We observed that C. albicans with different biofilm-forming in vitro capacity induced