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    Development of peptide inhibitors against dengue virus infection by in silico desigh and in vitro studies
    (Mahidol University. Mahidol University Library and Knowledge Center, 2023) Aussara Panya; Pa-thai Yenchitsomanus; Chatchawan Srisawat; Mutita Junking; Kiattewee Choowongkomon
    the hydrophobic pocket on the E protein was the target, and the destabilization of virion structure organization through the disruption of the interaction between the envelope and membrane proteins, respectively. Following the first strategy, molecular docking..., and Huh7 cells at low-micromolar level. The molecular docking technique suggested that MLH40 interacting with envelope proteins can disrupt their regular dimer conformation. The binding of peptide to the target site was a key underlining the inhibitory
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    Purification and characterization of fluorescent probes from blue green algae
    (Mahidol University. Mahidol University Library and Knowledge Center, 2024) Luckana Laousoontornsiri; Dhirayos Wititsuwannakul; Pichit Tosukhowong
    . Phycocyanin was found as major components upon disruption of spirulina platensis by repeated freeze-thawing of the cell mass. The blue-green algae is abundant in natural water source and serves as a suitable staring terial. The deep blue supernate after
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    Identification of RNA-processing abnormalities of the PKD1 gene in Thai families with autosomal dominant polycystic kidney disease
    (Mahidol University. Mahidol University Library and Knowledge Center, 2023) Wanna Thongnoppakhun; Prapon Wilairat; Pa-thai Yenchitsomanus; Mathurose Ponglikitmongkol; Chintana Sirinavin
    the deletion did not disrupt the donor or acceptor splice site or branch site in this intron. As the result of exon 43 skipping, the translated polycystin-1 would have in-frame deletion of 97 amino acids in the transmembrane (TM) and loop regions, confirming