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Publication Metadata only Cyclooxygenase-2 expression in retinoblastoma: An immunohistochemical analysis(2010-03-01) La Ongsri Atchaneeyasakul; Mongkol Uiprasertkul; Adisak Trinavarat; Mahidol UniversityPurpose: Increased level of cyclooxygenase-2 (COX-2) plays a significant role in the pathogenesis of cancers. High expression of COX-2 has been demonstrated in several cancer types including retinoblastoma. However, the in vivo study did not confirm... retinoblastoma specimens obtained during 1995 to 2005. Clinical and histopathological data were recorded. Immunohistochemical evaluation of COX-2 expression was performed using a rabbit monoclonal antibody to human cyclooxygenase-2. Results: Forty-four of 55Publication Metadata only Total synthesis of racemosol and de-O-methylracemosol, potent cyclooxygenase (COX) inhibitors and antimalarial agents(2006-01-16) Patcharaporn Sae-Lao; Prasat Kittakoop; Shuleewan Rajviroongit; Mahidol University; Thailand National Center for Genetic Engineering and BiotechnologyThe total synthesis of antimalarial and cyclooxygenase inhibitors, racemosol and de-O-methylracemosol, is described. The key steps involved the lateral lithiation reaction of ortho-methyl tolulate and the pyran formation via a tandem demethylationPublication Metadata only Possible role of cyclooxygenase-2 inhibitors as anticancer agents(2008-02-02) S. Boonsoda; P. Wanikiat; Mahanakorn University of Technology; Mahidol UniversityPublication Metadata only Human β-defensin-3 up-regulates cyclooxygenase-2 expression and prostaglandin E2 synthesis in human gingival fibroblasts(2010-08-01) P. Chotjumlong; S. Khongkhunthian; S. Ongchai; V. Reutrakul; Suttichai Krisanaprakornkit; Chiang Mai University; Mahidol UniversityChotjumlong P, Khongkhunthian S, Ongchai S, Reutrakul V, Krisanaprakornkit S. Human β-defensin-3 up-regulates cyclooxygenase-2 expression and prostaglandin E2synthesis in human gingival fibroblasts. J Periodont Res 2010; 45: 464-470. © 2010 John...BDs could induce cyclooxygenase-2 (COX-2) expression and prostaglandin E2 (PGE2) synthesis in non-immune cells, such as human gingival fibroblasts. Material and Methods: Cultured fibroblasts were treated with different concentrations of hBD-1, -2, -3Publication Metadata only Publication Metadata only New racemosol derivatives as potent cyclooxygenase (COX) inhibitors(2005-12-01) Saiphon Songarsa; Shuleewan Rajviroongit; Darinee Sae-Tang; Supa Hannongbua; Kanyawim Kirtikara; Prasat Kittakoop; Mahidol University; Kasetsart University; Thailand National Center for Genetic Engineering and BiotechnologyRacemosol (1) and 10-O-demethylracemosol (2), natural products from Bauhinia malabarica Roxb., exhibit potent in vitro anti-inflammatory activities against cyclooxygenase-1 and -2 (COX-1 and -2) enzymes. To investigate the structure - activityPublication Metadata only Biological activity evaluation and molecular docking study of chromone derivatives as cyclooxygenase-2 inhibitors(2017-03-01) Chirattikan Maicheen; Narumol Phosrithong; Jiraporn Ungwitayatorn; Mahidol University; Siam University© 2017, Springer Science+Business Media New York. A series of chromone derivatives have been evaluated as potential cyclooxygenase-2 (COX-2) inhibitors. The four most potent compounds, 48, 41, 39, and 35 displayed IC50values of 3.30, 6.86, 7Publication Metadata only Initial response of endothelial cells to acute stimulation with a lipid component: Increase cyclooxygenase activity by induction of COX-2 through activation of tyrosine kinase(2010-12-01) Duangporn Plasen; Pravit Akarasereenont; Kitirat Techatraisak; Sirikul Chotewuttakorn; Athiwat Thaworn; Mahidol UniversityObjective: To study the initial response of endothelial cells acutely stimulated with a lipid component in the aspect of cyclooxygenase (COX) function which needed for prostacyclin synthesis, an endogenous antiatherogenic agent secreted fromPublication Metadata only Aberrant cyclooxygenase isozyme expression in human intrahepatic cholangiocarcinoma(2001-01-19) S. Chariyalertsak; V. Sirikulchayanonta; D. Mayer; A. Kopp-Schneider; G. Fürstenberger; F. Marks; K. Müller-Decker; National Cancer Institute Thailand; Mahidol University; German Cancer Research CenterMethods - Cellular localisation of the cyclooxygenase (COX) isozymes COX-1 and COX-2 was analysed in 24 cholangiocarcinomas, including 17 matched tissues originating from non-tumorous liver tissue adjacent to tumours and seven biopsies of normalPublication Metadata only Comparison of gastrointestinal adverse effects between cyclooxygenase-2 inhibitors and non-selective, non-steroidal anti-inflammatory drugs plus proton pump inhibitors: A systematic review and meta-analysis(2013-07-01) Saharat Jarupongprapa; Prapassorn Ussavasodhi; Wanruchada Katchamart; Nakornprathom Hospital; Mahidol UniversityBackground: There are conflicting and inconsistent data regarding the gastrointestinal (GI) protective effect of cyclooxygenase-2 (COX-2) inhibitors and of non-steroidal anti-inflammatory drugs (NSAIDs) plus proton-pump inhibitors (PPI). Aim