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Publication Metadata only Identifying safety indicators of new drug Safety Monitoring Programme (SMP) in Thailand(2007-01-01) Yaowalak Amrumpai; Niyada Kiatying-Angsulee; Kanittha Chamroonsawasdi; Chulalongkorn University; Mahidol University; Silpakorn UniversityThe Safety Monitoring Programme (SMP), Thailand's new drug safety monitoring system, aims to perform new drug safety profiles for the country. There have been an increasing number of new drugs in Thailand, and only a few studies have explored... this particular issue. This study was a part of a situational analysis of the new drug Safety Monitoring Programme in Thailand. The objective was to identify safety indicators of the SMP system through the structure, process, and outcome model. A three-roundPublication Metadata only Simplified antimalarial therapeutic monitoring: using the day-7 drug level?(2008-04-01) Nicholas J. White; Kasia Stepniewska; Karen Barnes; Ric N. Price; Julie Simpson; Mahidol University; Churchill Hospital; University of Cape Town; Menzies School of Health Research; University of MelbourneThe blood concentration profiles of most antimalarial drugs vary considerably between patients. The interpretation of antimalarial drug trials evaluating efficacy and effectiveness would be improved considerably if the exposure of the infecting... parasite population to the antimalarial drug treatment could be measured. Artemisinin combination treatments are now recommended as first-line drugs for the treatment of falciparum malaria. Measurement of the blood, serum or plasma concentrationPublication Open Access A case report of intravenous posaconazole in hepatic and renal impairment patient with invasive Aspergillus terreus infection: safety and role of therapeutic drug monitoring(2017) Pitchaya Dilokpattanamongkol; Panadda Panusitthikorn; Rasda Boonprasert; Methee Chayakulkeeree; Porpon Rotjanapan; Mahidol University. Faculty of Pharmacy. Department of Pharmacy; Mahidol University. Faculty of Medicine, Siriraj Hospital. Department of Pharmacy; Mahidol University. Faculty of Medicine, Siriraj Hospital. Clinical Toxicology Laboratory, Siriraj Poison Control Center; Mahidol University. Faculty of Medicine, Siriraj Hospital. Division of Infectious Diseases and Tropical Medicine,; Mahidol University. Department of Medicine, Ramathibodi Hospital. Division of Infectious Diseasesinfection. To our knowledge, this is the first report of intravenous posaconazole use in IA due to A. terreus with hepatic and renal impairment focusing on drug safety and role of therapeutic drug monitoring (TDM). Case presentation: A 37-year-oldPublication Open Access A case report of intravenous posaconazole in hepatic and renal impairment patient with invasive Aspergillus terreus infection: safety and role of therapeutic drug monitoring(2017) Pitchaya Dilokpattanamongkol; Panadda Panusitthikorn; Rasda Boonprasert; Methee Chayakulkeeree; Porpon Rotjanapan; Mahidol University. Faculty of Pharmacy. Department of Pharmacy; Mahidol University. Faculty of Medicine, Siriraj Hospital. Department of Pharmacy; Mahidol University. Faculty of Medicine, Siriraj Hospital. Clinical Toxicology Laboratory, Siriraj Poison Control Center; Mahidol University. Faculty of Medicine, Siriraj Hospital. Division of Infectious Diseases and Tropical Medicine.; Mahidol University. Department of Medicine, Ramathibodi Hospital. Division of Infectious Diseasesinfection. To our knowledge, this is the first report of intravenous posaconazole use in IA due to A. terreus with hepatic and renal impairment focusing on drug safety and role of therapeutic drug monitoring (TDM). Case presentation: A 37-year-oldPublication Metadata only The utility of the World Health Organization - The Uppsala Monitoring Centre (WHO-UMC) system for the assessment of adverse drug reactions in hospitalized children(2008-12-01) Chutsumarn Tantikul; Naruemon Dhana; Kowit Jongjarearnprasent; Nualanong Visitsunthorn; Pakit Vichyanond; Orathai Jirapongsananuruk; Mahidol UniversityAlthough the World Health Organization-The Uppsala Monitoring Centre (WHO-UMC) system has been suggested as a practical tool for classifying adverse drug reactions (ADRs), verification of such system has not been examined. The objective... of this study was to evaluate the usefulness of the WHO-UMC classification for the diagnosis of ADRs. The gold standard was the results of drug challenges and serum tryptase in cases of anaphylaxis. Twenty-seven children had ADRs classified by the WHO-UMC systemPublication Metadata only Drug errors from the Thai anesthesia incidents monitoring study: Analysis of 1,996 incident reports(2012-08-01) Somrat Charuluxananan; Wimonrat Sriraj; Worawut Lapisatepun; Chaiyapruk Kusumaphanyo; Wichai Ittichaikulthol; Thanarat Suratsunya; Chulalongkorn University; Khon Kaen University; Chiang Mai University; Srinakharinwirot University; Mahidol University; Faculty of Medicine, Thammasat UniversityBackground: The Royal College of Anesthesiologists of Thailand arranged the Thai Anesthesia Incidents Monitoring Study (Thai AIMS) to investigate the clinical course, outcome, contributing factors, and suggested preventive strategies for anesthesia... related adverse events including drug errors. Methods: As part of the Thai AIMS, perioperative anesthesia incident reports of adverse events were collected on an anonymous and voluntary basis from 51 participating hospitals across Thailand between JanuaryPublication Metadata only HIV-1 drug resistance mutations among antiretroviral-naïve HIV-1-infected patients in Asia: Results from the TREAT Asia studies to evaluate resistance-monitoring study(2011-04-15) Somnuek Sungkanuparph; Rebecca Oyomopito; Sunee Sirivichayakul; Thira Sirisanthana; Patrick C.K. Li; Pacharee Kantipong; Christopher K.C. Lee; Adeeba Kamarulzaman; Liesl Messerschmidt; Matthew G. Law; Praphan Phanuphak; Mahidol University; Chulalongkorn University; Foundation for AIDS Research; Research Institute for Health Sciences; Chiang Rai Regional Hospital; Kirby Institute; Queen Elizabeth Hospital Hong Kong; Hospital Sungai Buloh; University of Malaya; Faculty of Medicine, Ramathibodi Hospital, Mahidol University(See editorial commentary by Jordan on pages 1058-1060.)Of 682 antiretroviral-naïve patients initiating antiretroviral therapy in a prospective, multicenter human immunodeficiency virus type 1 (HIV-1) drug resistance monitoring study involving 8... sites in Hong Kong, Malaysia, and Thailand, the prevalence of patients with ≥1 drug resistance mutation was 13.8%. Primary HIV drug resistance is emerging after rapid scaling-up of antiretroviral therapy use in Asia. © 2011 The Author.Publication Metadata only Development and Validation of Liquid Chromatography/Tandem Mass Spectrometry Analysis for Therapeutic Drug Monitoring of Risperidone and 9-Hydroxyrisperidone in Pediatric Patients with Autism Spectrum Disorders(2016-11-01) Natchaya Vanwong; Santirat Prommas; Apichaya Puangpetch; Yaowaluck Hongkaew; Nopadol Nuntamool; Chalitpol Na Nakorn; Nattawat Ngamsamut; Penkhae Limsila; Chonlaphat Sukasem; Mahidol University; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Thailand Ministry of Public Health-day precision of RIS was ≤7.27% CV and ≤7.41% CV for 9-OH-RIS. The extraction recovery of RIS and 9-OH-RIS were 95.01 ± 7.31–112.62 ± 7.50% and 90.27 ± 11.15–114.00 ± 10.35%, respectively. This method was applied in the therapeutic drug monitoring...© 2016 Wiley Periodicals, Inc. Background: Risperidone (RIS) is a widely used atypical antipsychotic drug. We developed and validated a sensitive and accurate LC-MS/MS method, which requires a small-volume of plasma and small-volume injectionPublication Metadata only Reasons for misuse of prescription medication among physicians undergoing monitoring by a physician health program(2013-09-01) Lisa J. Merlo; Supachoke Singhakant; Simone M. Cummings; Linda B. Cottler; University of Florida; Mahidol University; Numerof and Associates, Inc.referred to a physician health program for monitoring because of substance-related impairment, to develop better mechanisms for prevention and intervention. Methods: A total of 55 physicians (94.5% male) who were being monitored by their State physician... conducted to examine themes. Results: All participantswere diagnosed with substance dependence, and 69.1% of them endorsed a history ofmisusing prescription drugs. Participants documented the following 5 primary reasons for prescription drug misuse: (1Publication Open Access Perspectives on antimicrobial resistance in livestock and livestock products in ASEAN countries(2014) Amornthep Archawakulathep; Thi Kim, Chung Ta; Meunsene, Dethaloun; DidikHandijatno; Hassim, HaslizaAbu; Rovira, Hope R. G.; Myint, Khin Sandar; Baldrias, Loinda R.; Sothy, Meas; Aung, Min; Wahyu, Nenny H.; Chea, Rortana; Sookruetai Boonmasawai; Vannamahaxay, Soulasack; Sunpetch Angkititrakul; Collantes, Therese M. A.; Van, Tho Nguyen; Veerasak Punyapornwithaya; ZunitaZakaria; Rungtip Chuanchuen; Mahidol University. Faculty of Veterinary Science, of which AMR is one of the major concerns. There is a need for all ASEAN nations to harmonize its AMR monitoring and surveillance programmes in order to strengthen the control and institute prevention strategies in the region. Currently, public health... systems dealing with monitoring and control in ASEAN countries are still highly diverse and require a unifying action. National monitoring and control programmes for AMR have not been successfully established in most ASEAN countries and a regional