4 results
Search Results
Now showing 1 - 4 of 4
Publication Metadata only Modified Small-Volume Jet Nebulizer Based on CFD Simulation and Its Clinical Outcomes in Small Asthmatic Children(2019-01-01) Sermsri Santati; Jatuporn Thongsri; Parinya Sarntima; King Mongkut's Institute of Technology Ladkrabang; Faculty of Medicine, Ramathibodi Hospital, Mahidol University© 2019 Sermsri Santati et al. The small-volume jet nebulizer (SVJN) is an aerosol device used to treat respiratory illnesses. Major problems for aerosol treatment in small children include the penetration of particles to the lower lungs due... to irregular and small volume of a child patient's breath while the nebulizers used are the same models intended for adults. This adult SVJN produces a huge number of particles at a higher speed than small children can intake. To solve this problemPublication Open Access ผลการประยุกต์อุปกรณ์พ่นยาแบบฝอยละอองต่อพฤติกรรมยอมรับการพ่นยา และผลลัพธ์ทางคลินิกในเด็กเล็กที่มีภาวะหลอดลมหดเกร็ง(2556) วรฤทัย กำลังหาญ; เสริมศรี สันตติ; เรณู พุกบุญมี; พิศสมัย อรทัย; Woraruetai Kamlangharn; Sermsri Santati; Renu Pukboonmee; Pisamai Orathai; มหาวิทยาลัยมหิดล. คณะแพทยศาสตร์โรงพยาบาลรามาธิบดี. โรงเรียนพยาบาลรามาธิบดีThis study is a quasi-experimental research aimed to evaluate effects of a modified small volume nebulizer on the acceptable behaviors and clinical outcomes, including oxygen saturation, respiratory rate, heart rate, and the degree of wheezing... sound, in young children with bronchospasm. Patients were treated with the aerosolized Salbutamol, with the regular and the modified small volume nebulizers, at outpatient pediatrics department of 2 hospitals in Thailand. Data were collected from JulyPublication Open Access ผลของการใช้หนังสือการ์ตูนต่อความกลัวการได้รับยาพ่นแบบฝอยละอองในผู้ป่วยเด็กวัยก่อนเรียน(2560) ทัศนีย์ ไทยนิรันประเสริฐ; Tadsanee Thainirunprasert; สมพร สุนทราภา; Somporn Suntharapa; ศศิธร จันทรทิณ; Sasitorn Chantaratin; ฤดีมาศ อัยวรรณ; Rudeemas Aiyawan; มหาวิทยาลัยมหิดล. คณะพยาบาลศาสตร์. ภาควิชากุมารเวชศาสตร์; มหาวิทยาลัยมหิดล. คณะแพทยศาสตร์ศิริราชพยาบาลPurpose: To examine the effect of a cartoon book on fear of preschool children receiving small volume nebulizer. Design:Quasi-experimental design (two group pretest-posttest design). Methods: The sample was 24 pediatric patients aged 3-6 years who... were treated with small volume nebulizer in a tertiary hospital in Bangkok. The sample were randomly assigned to the control group (N = 12) and the experimental group (N = 12). The control group received routine nursing carePublication Open Access NLRC4 and TLR5 each contribute to host defense in respiratory melioidosis.(2014-09-18) West, T. Eoin; Myers, Nicolle D.; Narisara Chantratita; นริศรา จันทราทิตย์; Wirongrong Chierakul; วิรงค์รอง เจียรกุล; Direk Limmathurotsakul; ดิเรก ลิ้มมธุรสกุล; Vanaporn Wuthiekanun; วรรณพร วุฒิเอกอนันต์; Miao, Edward A.; Hajjar, Adeline M.; Peacock, Sharon J.; Liggitt, H. Denny; Skerrett, Shawn J.; West, T. Eoin; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit.; Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicine.; Mahidol University. Faculty of Tropical Medicine. Department of Microbiology and Immunology.; Mahidol University. Faculty of Tropical Medicine. Department of Tropical Hygiene.Burkholderia pseudomallei causes the tropical infection melioidosis. Pneumonia is a common manifestation of melioidosis and is associated with high mortality. Understanding the key elements of host defense is essential to developing new therapeutics for melioidosis. As a flagellated bacterium encoding type III secretion systems, B. pseudomallei may trigger numerous host pathogen recognition receptors. TLR5 is a flagellin sensor located on the plasma membrane. NLRC4, along with NAIP proteins, assembles a canonical caspase-1-dependent inflammasome in the cytoplasm that responds to flagellin (in mice) and type III secretion system components (in mice and humans). In a murine model of respiratory melioidosis, Tlr5 and Nlrc4 each contributed to survival. Mice deficient in both Tlr5 and Nlrc4 were not more susceptible than single knockout animals. Deficiency of Casp1/Casp11 resulted in impaired bacterial control in the lung and spleen; in the lung much of this effect was attributable to Nlrc4, despite relative preservation of pulmonary IL-1β production in Nlrc4(-/-) mice. Histologically, deficiency of Casp1/Casp11 imparted more severe pulmonary inflammation than deficiency of Nlrc4. The human NLRC4 region polymorphism rs6757121 was associated with survival in melioidosis patients with pulmonary involvement. Co-inheritance of rs6757121 and a functional TLR5 polymorphism had an additive effect on survival. Our results show that NLRC4 and TLR5, key components of two flagellin sensing pathways, each contribute to host defense in respiratory melioidosis.