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Publication Open Access Factors Affecting the Quality of Life in Children with Epilepsy(2021) Arthittaya Kaenkrai; Autchareeya Patoomwan; Suporn Wongvatunyu; Apasri Lusawat; อาทิตยา แก่่นไกร; อัจฉรียา ปทุุมวัน; ศุุภร วงศ์วทัญญู; อาภาศรี ลุุสวัสดิ์์; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Ramathibodi School of Nursingof illness data of children with epilepsy, the Chulalongkorn Family Inventory (CFI), and the Quality of Life in Childhood Epilepsy (QOLCE-16). Data analysis used descriptive statistics, Pearson’s product-moment correlation coefficient, and multiple... in children with epilepsy, including epilepsy severity, comorbidity, and family functioning. The sample, which consisted of 90 caregivers of children with epilepsy between the ages of 4 to 15 years, was recruited from the pediatric neurological out-patientPublication Open Access ปัจจัยที่มีความสัมพันธ์กับการรับประทานยาอย่างสม่ำเสมอของเด็กโรคลมชัก(2560) ชุติมาภรณ์ กังวาฬ; ชื่นฤดี คงศักดิ์ตระกูล; วันทนา มณีศรีวงศ์กูล; อนันต์นิตย์ วิสุทธิพันธ์; Chutimaporn Kangwal; Chuanruedee Kongsaktrakol; Wantana Maneesriwongul; Anannit Visudtibhan; มหาวิทยาลัยมหิดล. คณะแพทยศาสตร์โรงพยาบาลรามาธิบดี. โรงเรียนพยาบาลรามาธิบดีThe objectives of this study were to explore medication adherence among children with epilepsy and to examine factors related to medication adherence among children with epilepsy. The samples consisted of 109 children with epilepsy and 109... caregivers of children with epilepsy. The participants were selected by purposive sampling. Data were collected by the following questionnaires: the Questionnaire on Demographic Characteristics of Children and Caregivers, the Visual Analog Scale to AssessPublication Open Access ปัจจัยทำนายการปรับตัวของผู้ดูแลเด็กโรคลมชัก(2554) ปูชิตา ทำเนา; ชื่นฤดี คงศักดิ์ตระกูล; อัจฉรียา ปทุมวัน; Pooshita Thamnaw; Chuanruedee Kongsaktrakul; Autchareeya Patoomwan; มหาวิทยาลัยมหิดล. คณะแพทยศาสตร์โรงพยาบาลรามาธิบดี. โรงเรียนพยาบาลรามาธิบดีThis descriptive study aimed to investigate the ability of study variables (perceived seizure severity, social support, years of education, and family income) to predict adaptation among caregivers of children with epilepsy. Roy's adaptation model... was used as the conceptual framework. Purposive sampling was used to recruit a sample of 94 caregivers of children with epilepsy at the Pediatric Neurological Clinic, Outpatient Department, Ratchaburi Hospital. Instruments for data collection consistedPublication Open Access Cost-utility analysis of 10- and 13-valent pneumococcal conjugate vaccines: protection at what price in the Thai context?(2013-06) Wantanee Kulpenga; Pattara Leelahavarong; Waranya Rattanavipapong; Baggett, H. C; Vorasith Sornsrivichai; Aronrag Meeyai; Warunee Punpanich; อรุณรักษ์ มีใย; Wantanee Kulpenga; Mahidol University. Faculty of Public Health. Department of EpidemiologyOBJECTIVE: This study aims to evaluate the costs and outcomes of offering the 10-valent pneumococcal conjugate vaccine (PCV10) and 13-valent pneumococcal conjugate vaccine (PCV13) in Thailand compared to the current situation of no PCV vaccination. METHODS: Two vaccination schedules were considered: two-dose primary series plus a booster dose (2+1) and three-dose primary series plus a booster dose (3+1). A cost-utility analysis was conducted using a societal perspective. A Markov simulation model was used to estimate the relevant costs and health outcomes for a lifetime horizon. Costs were collected and values were calculated for the year 2010. The results were reported as incremental cost-effectiveness ratios (ICERs) in Thai Baht (THB) per quality adjusted life year (QALY) gained, with future costs and outcomes being discounted at 3% per annum. One-way sensitivity analysis and probabilistic sensitivity analysis using a Monte Carlo simulation were performed to assess parameter uncertainty. RESULTS: Under the base case-scenario of 2+1 dose schedule and a five-year protection, without indirect vaccine effects, the ICER for PCV10 and PCV13 were THB 1,368,072 and THB 1,490,305 per QALY gained, respectively. With indirect vaccine effects, the ICER of PCV10 was THB 519,399, and for PCV13 was THB 527,378. The model was sensitive to discount rate, the change in duration of vaccine protection and the incidence of pneumonia for all age groups. CONCLUSIONS: At current prices, PCV10 and PCV13 are not cost-effective in Thailand. Inclusion of indirect vaccine effects substantially reduced the ICERs for both vaccines, but did not result in cost effectiveness.Publication Open Access ผลของโปรแกรมควบคุมการชักผ่านแอปพลิเคชันไลน์ต่อความรอบรู้ด้านสุขภาพและพฤติกรรมสุขภาพของผู้ป่วยโรคลมชัก(2565) ณัฐปัณฑ์ แก้วเงิน; พูลสุข เจนพานิชย์ วิสุทธิพันธ์; อนันต์นิตย์ วิสุทธิพันธ์; Natthapan Kaewnguen; Poolsuk Janepanish Visudhtibhan; Anannit Visudhtibhan; มหาวิทยาลัยมหิดล. คณะแพทยศาสตร์โรงพยาบาลรามาธิบดี. โรงเรียนพยาบาลรามาธิบดีframework to guide the study was based on Nutbeam’s health literacy concept and relevant literature. The participants were 18 patients with epilepsy who attended the outpatient neurological clinic at Rayong Hospital. All received an education program... entitled “Epilepsy Control Program.” This program consisted of an education learning package about epilepsy and a skill-training program to develop health literacy and health behaviors, distributed to the participants via the LINE application. The durationPublication Open Access Clinically unapparent infantile thiamin deficiency in Vientiane, Laos.(2011-02-22) Khounnorath, Sengmanivong; Chamberlain, Karen; Taylor, Ann M.; Soukaloun, Douangdao; Mayxay, Mayfong; Lee, Sue J.; Phengdy, Bounthom; Luangxay, Khonsavanh; Sisouk, Kongkham; Soumphonphakdy, Bandit; Latsavong, Khaysy; Akkhavong, Kongsin; White, Nicholas J.; Newton, Paul N.; Newton, Paul N.; Mahidol University. Faculty of TropicalMedicine. Mahidol-Oxford Tropical Medicine Research Unit.BACKGROUND: Beriberi occurs in Vientiane, Lao PDR, among breastfed infants. Clinical disease may be the tip of an iceberg with subclinical thiamin deficiency contributing to other illnesses. Thiamin treatment could improve outcome. METHODOLOGY/PRINCIPAL FINDINGS: A cohort of 778 sick infants admitted during one year without clinical evidence of beriberi were studied prospectively and erythrocyte transketolase assays (ETK) performed. Biochemical thiamin deficiency was defined both in terms of the activation coefficient (α>31%) and basal ETK activity <0.59 micromoles/min/gHb. Of the 778 infants, median (range) age was 5 (0-12) months, 79.2% were breastfed, 5.1% had α>31% and 13.4 % basal ETK<0.59 micromoles/min/gHb. Infants≥2 months old had a higher frequency of biochemical markers of thiamin deficiency. Mortality was 5.5% but, among infants ≥2 months old, mortality was higher in those with basal ETK<0.59 micromoles/min/gHb (3/47, 6.4%) than in those with basal ETK≥0.59 micromoles/min/gHb (1/146, 0.7%) (P=0.045, relative risk=9.32 (95%CI 0.99 to 87.5)). Multivariate regression analysis indicated that infant age≥2 months and fewer maternal years of schooling were independently associated with infant basal ETK<0.59 micromoles/min/gHb. CONCLUSIONS/SIGNIFICANCE: Clinically unapparent thiamin deficiency is common among sick infants (≥2 months old) admitted to hospital in Vientiane. This may contribute to mortality and a low clinical threshold for providing thiamin to sick infants may be needed.