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    PublicationOpen Access
    Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria
    (2009-12-15) Conroy, Andrea L.; Lafferty, Erin I.; Lovegrove, Fiona E.; Srivicha Krudsood; ศรีวิชา ครุฑสูตร; Noppadon Tangpukdee; นพดล ตั้งภักดี; Liles, W. Conrad; Kain, Kevin C.; Kain, Kevin C.; Mahidol University. Faculty of Tropical Medicine.
    BACKGROUND: Severe and cerebral malaria are associated with endothelial activation. Angiopoietin-1 (ANG-1) and angiopoietin-2 (ANG-2) are major regulators of endothelial activation and integrity. The aim of this study was to investigate... the clinical utility of whole blood angiopoietin (ANG) levels as biomarkers of disease severity in Plasmodium falciparum malaria. METHODS: The utility of whole blood ANG levels was examined in Thai patients to distinguish cerebral (CM; n = 87) and severe
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    PublicationOpen Access
    Severe vivax malaria: a systematic review and meta-analysis of clinical studies since 1900
    (2014) Rahimi, Bilal Ahmad; Ammarin Thakkinstian; White, Nicholas J; Chukiat Sirivichayakul; Dondorp, Arjen M; Watcharee Chokejindachai; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit
    articles published since 1900. Medline and Scopus databases were searched for original papers on severe vivax malaria, using as inclusion criteria modified 2010 WHO criteria for the diagnosis of severe falciparum malaria. Articles before 1949 were...Background: Malaria caused by Plasmodium vivax was long considered to have a low mortality, but recent reports from some geographical areas suggest that severe and complicated vivax malaria may be more common than previously thought. Methods
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    PublicationOpen Access
    Use of a rapid test to assess plasma Plasmodium falciparum HRP2 and guide management of severe febrile illness
    (2015) Ipsita Sinha; Nattwut Ekapirat; Dondorp, Arjen M.; Woodrow, Charles J.; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit (MORU)
    Background: Plasma Plasmodium falciparum histidine-rich protein-2 (PfHRP2) is the most accurate biomarker for severe malaria, but its measurement by ELISA has been considered too unwieldy to incorporate into clinical management. Methods: Plasma... to ELISA and acceptable limits of agreement. Three different dilutions of a well characterized set of admission samples from uncomplicated and severe malaria patients studied in a low transmission setting gave an area under the receiver operator
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    PublicationOpen Access
    Molecular basis of human cerebral malaria development
    (2016) Saw Thu Wah; Hathairad Hananantachai; Usanee Kerdpin; Chotiros Plabplueng; Virapong Prachayasittikul; Pornlada Nuchnoi; Mahidol University. Faculty of Medical Technology. Department of Clinical Microscopy; Mahidol University. Faculty of Medical Technology. Center for Research and Innovation
    Cerebral malaria is still a deleterious health problem in tropical countries. The wide spread of malarial drug resistance and the lack of an effective vaccine are obstacles for disease management and prevention. Parasite and human genetic factors... genomic data and a novel body of knowledge, including the identification of microRNAs, are being increasingly accumulated for the development of laboratory testing cassettes for cerebral malaria prevention. Therefore, understanding of the underlying
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    PublicationOpen Access
    Effect of malaria in pregnancy on foetal cortical brain development: a longitudinal observational study
    (2012) Rijken, Marcus J; Merel Charlotte de Wit; Mulder, Eduard JH; Suporn Kiricharoen; Noaeni Karunkonkowit; Tamalar Paw; Visser, Gerard HA; McGready, Rose; Nosten, François H; Pistorius, Lourens R; Mahidol University. Faculty of Tropical Medicine
    Background: Malaria in pregnancy has a negative impact on foetal growth, but it is not known whether this also affects the foetal nervous system. The aim of this study was to examine the effects of malaria on foetal cortex development by three... grading was possible in 161 out of 223 (72%) serial foetal brain images in pregnant women living in a malaria endemic area. There was no difference between foetal cortical development or brain volumes at any time in pregnancy between women
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    PublicationOpen Access
    Coma in fatal adult human malaria is not caused by cerebral oedema
    (2011-09-17) Medana, Isabelle M.; Day, Nicholas P.J.; Navakanit Sachanonta; นวขนิษฐ์ สัจจานนท์; Mai, Nguyen T.H.; Dondorp, Arjen M.; Emsri Pongponratn; เอี่ยมศรี พงศ์พนรัตน์; Hien, Tran T.; White, Nicholas J.; Turner, Gareth D.H.; Turner, Gareth D.H.; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Research Unit.; Mahidol University. Faculty of Tropical Medicine. Department of Tropical Pathology.
    BACKGROUND: The role of brain oedema in the pathophysiology of cerebral malaria is controversial. Coma associated with severe Plasmodium falciparum malaria is multifactorial, but associated with histological evidence of parasitized erythrocyte... (P = .02). CONCLUSIONS: Histological evidence of cerebral oedema or immunohistochemical evidence of localised loss of vascular integrity did not correlate with the occurrence of pre-mortem coma in adults with fatal falciparum malaria. Enhanced
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    PublicationOpen Access
    The duration of Plasmodium falciparum infections
    (2014) Ashley, Elizabeth A; White, Nicholas J; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit
    Plasmodium vivax and Plasmodium ovale are often considered the malaria parasites best adapted to long-term survival in the human host because of their latent exo-erythrocytic forms. The prevailing opinion until the middle of the last century... was that the maximum duration of Plasmodium falciparum infections was less than two years. Case reports and series investigating blood donors following accidental malaria infection of blood transfusion recipients and other sporadic malaria cases in non-endemic
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    PublicationOpen Access
    Exploring health practitioners’ acceptability of a prospective semi‑quantitative pfHRP2 device to define severe malaria in the Democratic Republic of Congo
    (2015) Haan, Freek de; Onyamboko, Marie A.; Fanello, Caterina I.; Woodrow, Charles J.; Yoel Lubell; Boon, Wouter P. C.; Dondorp, Arjen M.; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit
    Background: A rapid diagnostic tool is being developed to discern severely ill children with severe malaria from children who are ill with alternative febrile diseases but have coincidental peripheral blood parasitaemia. The device semi...-quantitatively measures plasma pfHRP2 and has the potential to reduce mortality in children with severe febrile illnesses by improving diagnosis. The aim of this study is to identify contributing and inhibiting factors that affect healthcare practitioners
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    PublicationOpen Access
    Long‑term impact of childhood malaria infection on school performance among school children in a malaria endemic area along the Thai–Myanmar border
    (2015) Nutchavadee Vorasan; Wirichada Pan‑Ngum; Podjanee Jittamala; Wanchai Maneeboonyang; Prasert Rukmanee; Saranath Lawpoolsri; Mahidol University. Faculty of Tropical Medicine. Department of Tropical Hygiene
    Background: Children represent a high-risk group for malaria worldwide. Among people in Thailand who have malaria during childhood, some may have multiple malaria attacks during their lifetime. Malaria may affect neurological cognition in children..., resulting in short-term impairment of memory and language functions. However, little is known regarding the long-term effects of malaria infection on cognitive function. This study examines the long-term impact of malaria infection on school performance
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    PublicationOpen Access
    The role of previously unmeasured organic acids in the pathogenesis of severe malaria
    (2015) Herdman, M. Trent; Natthida Sriboonvorakul; Leopold, Stije J.; Sam Douthwaite; Sanjib Mohanty; M. Mahtab Uddin Hassan; Maude, Richard J.; Kingston, Hugh WF; Katherine Plewes; Prakaykaew Charunwatthana; Kamolrat Silamut; Woodrow, Charles J.; Kesinee Chotinavich; Hossain, Md. Amir; Faiz, M. Abul; Saroj Mishra; Natchanun Leepipatpiboon; White, Nicholas J.; Day, Nicholas PJ; Joel Tarning; Dondorp, Arjen M.; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit
    Introduction: Severe falciparum malaria is commonly complicated by metabolic acidosis. Together with lactic acid (LA), other previously unmeasured acids have been implicated in the pathogenesis of falciparum malaria. Methods: In this prospective... study, we characterised organic acids in adults with severe falciparum malaria in India and Bangladesh. Liquid chromatography-mass spectrometry was used to measure organic acids in plasma and urine. Patients were followed until recovery or death