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Publication Open Access An Overview of CyberKnife Robotic Radiosurgery(2009) Putipun Puataweepong; พุฒิพรรณ พัวทวีพงศ์; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Department of Diagnostic and Therapeutic Radiologytargets using a very accurate Image-to-Image correlation algorithm, and precisely cross-fires high-energy radiation from a lightweight linear accelerator by means of a highly manipulable robotic arm, Cyberknife radiosurgery is an effective alternative... to conventional surgery or radiation therapy for a range of tumors and some non-neoplastic disorders. This report will describe Cyberknife technology and oncologic applications in neurosurgery and throughout the body.Item Open Access Annual Report 2013 กองบริหารงานวิจัย มหาวิทยาลัยมหิดล(2014) มหาวิทยาลัยมหิดล. สำนักงานอธิการบดี. กองบริหารงานวิจัยPublication Open Access Stress cortisol and muscle stiffness in horses used for equine-assisted therapy(2017) Nuttawut Nuchprayoon; Nlin Arya; Pattama Ritruechai; Mahidol University. Faculty of Veterinary ScienceEquine-assisted therapy uses horseback riding to improve the patient's health and wellbeing. However, the possible stress and damage of this therapy on the back horse muscle (longissimus dorsi) are understudied. We studied the stress cortisol... and muscle stiffness of two ponies and a horse used for equine-assisted therapy on a child with autism. Salivary cortisol levels and heart rate were used as indicators of physiologic stress and a muscle indenter was employed to estimate the back muscleItem Open Access การบำรุงสุขภาพด้วยแพทย์ด้วยแพทย์ทางเลือก(2556) อัมพร กรอบทอง; มหาวิทยาลัยมหิดล. ศูนย์การแพทย์กาญจนาภิเษกPublication Open Access ตัวรับฮอร์โมนเอสโตรเจนและโปรเจสเตอโรนในเนื้อเยื่อเต้านมสุนัข(2552) สุกัญญา มณีอินทร์; มหาวิทยาลัยมหิดล. คณะสัตวแพทยศาสตร์, the studies of sex hormone manipulation might be important for hormone-dependent mammary tumors.Publication Open Access Thermoregulatory correlates of nausea in rats and musk shrews(2014) Sukonthar Ngampramuan; Matteo Cerri; Flavia Del Vecchio; Corrigan, Joshua J; Amornrat Kamphee; Dragic, Alexander S; Rudd, John A; Romanovsky, Andrej A; Eugene Nalivaiko; Mahidol University. Institute of Molecular BiosciencesNausea is a prominent symptom and major cause of complaint for patients receiving anticancer chemo- or radiation therapy. The arsenal of anti-nausea drugs is limited, and their efficacy is questionable. Currently, the development of new compounds...-HT3 receptor antagonist, which is used to treat nausea in patients in chemo- or radiation therapy, attenuated hypothermia by ~30%. In shrews, motion sickness was induced by a cyclical backand-forth motion (4 cm, 1 Hz, 15 min) and confirmedPublication Open Access Hybrid approach for left-sided colonic carcinoma obstruction; a case report(2011) Atthaphorn Trakarnsanga; Thawatchai Akaraviputh; Asada Methasate; Vitoon Chinswangwatanakul; Mahidol University. Faculty of Medicine Siriraj Hospital. Minimally Invasive Surgery unitTraditionally, there are several approaches to manage left-sided colonic carcinoma obstruction, such as tumor resection with primary anastomosis, tumor resection with end-colostomy and loop-colostomy. Recently, colonic stent insertion was introduced as a bridge prior to definite surgery. We demonstrated a hybrid approach for obstructed sigmoid carcinoma using colonic stent, followed by single incision laparoscopic colectomy (SILC). A 58 year-old man presented with complete left-sided colonic obstruction. He underwent emergency colonoscopy with metallic stent placement. One week later, he was performed SILC. He recovered well after the operation without any postoperative complications. The pathological result showed adequacy of oncologic resection. This hybrid approach of colonic stent insertion and SILC can be safely performed.Publication Open Access In vitro antimicrobial effects of mangosteen extract on peri-implantitis microflora in craniofacial implants.(2013-09) Shrestha, Binit; Sroisiri Thaweboon; สร้อยศิริ ทวีบูรณ์; Suwan Choonharuangdej; สุวรรณ ชุณหเรืองเดช; Boonyanit Thaweboon; บุญนิตย์ ทวีบูรณ์; Theerathavaj Srithavaj; ธีรธวัช ศรีธวัช; Sita Thaworanunta; สิตา ถาวรนันท์; Boonyanit Thaweboon; บุญนิตย์ ทวีบูรณ์; Mahidol University. Faculty of Dentistry. Maxillofacial Prosthetic Service; Mahidol University. Faculty of Dentistry. Department of Oral MicrobiologyIntroduction: Craniofacial implants has enabled restoration of congenital and acquired facial defects. However, peri-implantitis of the skin-abutment interface is a common drawback following implant placement. Objective: To determine the antimicrobial effects of mangosteen pericarp extract on peri-implantitis microflora found around craniofacial implants. Material and Methods: The mangosteen pericarp extract was tested against peri-implantitis microflora reference strains of Staphylococcus aureus ATCC6538, Candida albicans ATCC10231 and clinical strains of Staphylococcus aureus and Candida parapsilosis by disk diffusion test. Minimum inhibitory concentrations (MIC) and minimum cidal concentrations (MCC) were determined using modified agar dilution millipore method. The extract was further combined with a 50:50 mixture of polyethylene glycol and propylene glycol to form a paste and tested for antimicrobial effects. Results: Mangosteen extract showed inhibitory effects with reference strain of S. aureus at MIC and MCC at 1.25 mg/mL and 2.5 mg/mL and clinical strain at 2.5 mg/mL and 5 mg/mL respectively. On the contrary, it showed minimal or no reactivity against C. albicans and C. parapsilosis. The combination of the extract with polyethylene glycol and propylene glycol also showed a dose dependent inhibitory effect on S. aureus. Conclusion: Mangosteen extract had potential antimicrobial effects against S. aureus, which can be further studied and developed, to be used in the treatment of microorganism induced infection of skin-abutment interface of craniofacial implants.Publication Open Access ความรู้พื้นฐานเกี่ยวกับเซลล์ต้นกำเนิดมีเซนไคม์เพื่อใช้ทางสัตวแพทย์(2558) ปริญญา สามารถ; มหาวิทยาลัยมหิดล. คณะแพทยศาสตร์ศิริราชพยาบาล. ภาควิชาวิทยาภูมิคุ้มกันA stem cell is an undifferentiated cell that has special properties for two reasons (1) the ability to increase the number self-renewal and (2) the ability to be differentiated into many cell types, and can be classified into two types (1) embryonic stem cells and (2) adult stem cells. Recent reports found that the differentiated cells can be reprogrammed to embryonic stem-like cells known as induced pluripotent stem cells. In the field of veterinary medicine, much attention has been paid to mesenchymal stem cells (MSCs), one type of adult stem cells. Many reports reveal the success for treating animals; however, there are small number of research have been performed in Thailand. The advantages of using MSCs are it can be easily isolated and cultured, avoiding ethical problems, having little effect on host immune defense, low costs and can be further applied clinically. The limitations of using MSCs are purification, proliferation and differentiation capability. Therefore, a basic science of mesenchymal stem cells is very important for the research question and developments. Thailand should focus on clinical application for build the confidence and enhance the standard of veterinary medicine in Thailand in order to compare with veterinary profession from developed countries, especially innovative new treatment by using mesenchymal stem cells.Publication Open Access Comparison of the longissimus dorsi muscle tone in Thoroughbred racehorses before and after training(2016) Pichet Jewmongkonchai; Arunothai Muangma; Pattama Ritruechai; Mahidol University. Faculty of Veterinary Science. Department of Clinical Science and Public HealthThe longissimus dorsi is the largest back muscle of the horse and has the potential to contribute movement to the horse's back. Damage to the longissimus dorsi is very common to cause back injuries, which is also a major cause of poor performance and gait abnormalities in horses. The muscle indenter is a tool that allows measuring the stiffness of the back muscles. We hypothesized that the longissimus dorsi muscle tone after training would be stiffer than at rest. One sound mare and three gelding Thoroughbred racehorses were used in this study. The muscle tone was measured using a muscle indenter along both sides of the T14, T16, T18 and L2 longissimus dorsi muscle. Blood sample were collected to measure the blood lactate concentration before and after training. Heart rate was measured at rest and at 0, 5, 10, 15 and 20 minutes after training. We found a significant increase in muscle tone after training at T14, T16 and T18. The blood lactate concentration of studied horses significantly increased after training, although the values were still within the normal range. The recovery heart rates for all horses are tended to decrease (< 70 bpm) after 5 minutes of stopping exercise. We confirmed that the longissimus dorsi is a key muscle in horse movement that can be sensitive to relatively small training sessions; that is why this muscle is prone to get injured. Generally, the muscle intender was a successful tool of objectively measuring this muscle tone.