Publication: In vitro antimicrobial effects of mangosteen extract on peri-implantitis microflora in craniofacial implants.
Accepted Date
2013-07-25
Issued Date
2013-09
Resource Type
Language
eng
ISSN
0125-5614 (printed)
Rights
Mahidol University
Rights Holder(s)
Faculty of Dentistry Mahidol University
Bibliographic Citation
Shrestha B, Thaweboon S, Choonharuangdej S, Thaweboon B, Srithavaj T, Thaworanunta S. In vitro antimicrobial effects of mangosteen extract on peri-implantitis microflora in craniofacial implants. M Dent J. 2013; 33(3): 129-36.
Suggested Citation
Shrestha, Binit, Sroisiri Thaweboon, สร้อยศิริ ทวีบูรณ์, Suwan Choonharuangdej, สุวรรณ ชุณหเรืองเดช, Boonyanit Thaweboon, บุญนิตย์ ทวีบูรณ์, Theerathavaj Srithavaj, ธีรธวัช ศรีธวัช, Sita Thaworanunta, สิตา ถาวรนันท์ In vitro antimicrobial effects of mangosteen extract on peri-implantitis microflora in craniofacial implants.. Shrestha B, Thaweboon S, Choonharuangdej S, Thaweboon B, Srithavaj T, Thaworanunta S. In vitro antimicrobial effects of mangosteen extract on peri-implantitis microflora in craniofacial implants. M Dent J. 2013; 33(3): 129-36.. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/1072
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Title
In vitro antimicrobial effects of mangosteen extract on peri-implantitis microflora in craniofacial implants.
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Abstract
Introduction: Craniofacial implants has enabled restoration of congenital
and acquired facial defects. However, peri-implantitis of the skin-abutment
interface is a common drawback following implant placement.
Objective: To determine the antimicrobial effects of mangosteen pericarp
extract on peri-implantitis microflora found around craniofacial implants.
Material and Methods: The mangosteen pericarp extract was tested
against peri-implantitis microflora reference strains of Staphylococcus
aureus ATCC6538, Candida albicans ATCC10231 and clinical strains of
Staphylococcus aureus and Candida parapsilosis by disk diffusion test.
Minimum inhibitory concentrations (MIC) and minimum cidal concentrations
(MCC) were determined using modified agar dilution millipore method. The
extract was further combined with a 50:50 mixture of polyethylene glycol
and propylene glycol to form a paste and tested for antimicrobial effects.
Results: Mangosteen extract showed inhibitory effects with reference strain
of S. aureus at MIC and MCC at 1.25 mg/mL and 2.5 mg/mL and clinical
strain at 2.5 mg/mL and 5 mg/mL respectively. On the contrary, it showed
minimal or no reactivity against C. albicans and C. parapsilosis. The
combination of the extract with polyethylene glycol and propylene glycol
also showed a dose dependent inhibitory effect on S. aureus.
Conclusion: Mangosteen extract had potential antimicrobial effects against
S. aureus, which can be further studied and developed, to be used in the
treatment of microorganism induced infection of skin-abutment interface of
craniofacial implants.