7 results
Search Results
Now showing 1 - 7 of 7
Publication Open Access การลงทะเบียนงานวิจัยทางคลินิกของไทย TCTR(2561) อนุพงษ์ วีรบุรีนนท์; สุพัตรา สว่างกุล; Anupong Veeraburinon; Supattra Sawangkul; มหาวิทยาลัยมหิดล. คณะแพทยศาสตร์ศิริราชพยาบาล. งานวิจัย; มหาวิทยาลัยมหิดล. คณะแพทยศาสตร์ศิริราชพยาบาล. ภาควิชาจักษุวิทยาการลงทะเบียนงานวิจัยทางคลินิกของไทย (Thai Clinical Trials Registry, TCTR) จัดตั้งขึ้นโดยมูลนิธิส่งเสริมวิจัยทางการแพทย์ เพื่อเป็นฐานข้อมูลและเผยแพร่งานวิจัยทางคลินิกในประเทศไทย สนับสนุนและส่งเสริมการพัฒนางานวิจัยทางคลินิกให้โปร่งใส มีคุณภาพ... ประสิทธิภาพ ลดความซ้ำซ้อนของงานวิจัย และถูกต้องตามหลักจริยธรรมในการนำเสนอผลงาน ครอบคลุมถึงงานวิจัยของแพทย์ทางเลือก สมุนไพร รวมทั้งประชาสัมพันธ์ฐานข้อมูลสู่กลุ่มประเทศอาเซียน งานวิจัยที่ได้รับการลงทะเบียนใน TCTR สามารถนำเลขทะเบียนงานวิจัยไปแจ้งไว้ในบทความงานPublication Open Access Treatment outcomes of reduced-dose intravitreal ganciclovir for cytomegalovirus retinitis(2016) Pitipol Choopong; Kamolporn Vivittaworn; Duanphen Konlakij; Somanus Thoongsuwan; Auengporn Pituksung; Nattaporn Tesavibul; Mahidol University. Faculty of Medicine Siriraj Hospital. Department of Ophthalmologyin a resolution of retinitis, although it may be necessary to reduce systemic cytomegalovirus loads and mortality rates. Trial registration: The trial was registered with Thai Clinical Trials Registry (TCTR) on 16 March 2016 – TCTR20160316001.Publication Open Access Comparison of continuous femoral nerve block (CFNB/SA) and continuous femoral nerve block with mini-dose spinal morphine (CFNB/SAMO) for postoperative analgesia after total knee arthroplasty (TKA): a randomized controlled study(2016) Petchara Sundarathiti; Jadesadha Thammasakulsiri; Supawadee Supboon; Supalak Sakdanuwatwong; Molruedee Piangjai; Mahidol University. Ramathibodi Hospital. Department Of Anesthesiologyregistration: Thai Clinical Trial Registry (identifier: TCTR20150609003, date of registration: 6 June 2015).Publication Open Access Effect of simvastatin on monocyte chemoattractant protein-1 expression in endometriosis patients: a randomized controlled trial(2017) Wanwisa Waiyaput; Somphoch Pumipichet; Sawaek Weerakiet; Sasivimol Rattanasiri; Areepan Sophonsritsuk; Mahidol University. Department of Obstetrics & Gynecology, Ramathibodi Hospital . Reproductive Endocrinology and Infertility Unitregistration: Thai Clinical Trials Registry TCTR20130627003 Registered: June 27, 2013.Publication Open Access Platelet inhibitory effects of juices from Pachyrhizus erosus L. root and Psidium guajava L. fruit: a randomized controlled trial in healthy volunteers(2016) Thitiporn Thaptimthong; Thitima Kasemsuk; Nathawut Sibmooh; Supeenun Unchern; Mahidol University. Faculty of Science. Department of Pharmacology-promoting approach. Trial registration: Randomized controlled trial TCTR20150228001.Publication Open Access Chronic spinal cord injury treated with transplanted autologous bone marrow-derived mesenchymal stem cells tracked by magnetic resonance imaging: a case report(2015) Areesak Chotivichit; Monchai Ruangchainikom; Pipat Chiewvit; Adisak Wongkajornsilp; Kittipong Sujirattanawimol; Mahidol University. Faculty of Medicine Siriraj Hospital. Department of Orthopaedic SurgeryIntroduction: Intrathecal transplantation is a minimally invasive method for the delivery of stem cells, however, whether the cells migrate from the lumbar to the injured cervical spinal cord has not been proved in humans. We describe an attempt to track bone marrow-derived mesenchymal stem cells in a patient with a chronic cervical spinal cord injury. Case presentation: A 33-year-old Thai man who sustained an incomplete spinal cord injury from the atlanto-axial subluxation was enrolled into a pilot study aiming to track bone marrow-derived mesenchymal stem cells, labeled with superparamagnetic iron oxide nanoparticles, from intrathecal transplantation in chronic cervical spinal cord injury. He had been dependent on respiratory support since 2005. There had been no improvement in his neurological function for the past 54 months. Bone marrow-derived mesenchymal stem cells were retrieved from his iliac crest and repopulated to the target number. One half of the total cells were labeled with superparamagnetic iron oxide nanoparticles before transplantation to the intrathecal space between L4 and L5. Magnetic resonance imaging studies were performed immediately after the transplantation and at 48 hours, two weeks, one month and seven months after the transplantation. His magnetic resonance imaging scan performed immediately after the transplantation showed hyposignal intensity of paramagnetic substance tagged stem cells in the subarachnoid space at the lumbar spine area. This phenomenon was observed at the surface around his cervical spinal cord at 48 hours. A focal hyposignal intensity of tagged bone marrow-derived stem cells was detected at his cervical spinal cord with magnetic resonance imaging at 48 hours, which faded after two weeks, and then disappeared after one month. No clinical improvement of the neurological function had occurred at the end of this study. However, at 48 hours after the transplantation, he presented with a fever, headache, myalgia and worsening of his motor function (by one grade of all key muscles by the American Spinal Injury Association impairment scale), which lasted for 48 hours. Conclusion: Intrathecal injection of bone marrow-derived stem cells at the lumbar spine level could deliver the cells to the injured cervical spinal cord. Transient complications should be observed closely in the first 48 hours after transplantation. Further study should be carried out to evaluate the result of the treatment.Publication Open Access Two-year caries clinical study of the efficacy of novel dentifrices containing 1.5% arginine, an insoluble calcium compound and 1,450 ppm fluoride.(2013-11) Petcharat Kraivaphan; เพชรรัตน์ ไกรวพันธุ์; Cholticha Amornchat; ชลธิชา อมรฉัตร; Terdphong Triratana; เทอดพงษ์ ตรีรัตน์; Mateo, LR; Ellwood, R; Cummins, D; DeVizio, W; Zhang, Yun-Po; Zhang, Yun-Po; Mahidol University. Faculty of Dentistry. Department of Pharmacology; Mahidol University. Faculty of Dentistry. Department of Oral MicrobiologyA 2-year double-blind randomized three-treatment controlled parallel-group clinical study compared the anti-caries efficacy of two dentifrices containing 1.5% arginine, an insoluble calcium compound (di-calcium phosphate or calcium carbonate) and 1,450 ppm fluoride (F), as sodium monofluorophosphate, to a control dentifrice containing 1,450 ppm F, as sodium fluoride, in a silica base. The 6,000 participants were from Bangkok, Thailand and aged 6-12 years initially. They were instructed to brush twice daily, in the morning and evening, with their randomly assigned dentifrice. Three trained and calibrated dentists examined the children at baseline and after 1 and 2 years using the National Institute of Dental Research Diagnostic Procedures and Criteria. The number of decayed, missing and filled teeth (DMFT) and surfaces (DMFS) for the three study groups were very similar at baseline, with no statistically significant differences among groups. After 1 year, there were no statistically significant differences in caries increments among the three groups. After 2 years, the two groups using the dentifrices containing 1.5% arginine, an insoluble calcium compound and 1,450 ppm F had statistically significantly (p < 0.02) lower DMFT increments (21.0 and 17.7% reductions, respectively) and DMFS increments (16.5 and 16.5%) compared to the control dentifrice. The differences between the two groups using the new dentifrices were not statistically significant. The results of this pivotal clinical study support the conclusion that dentifrices containing 1.5% arginine, an insoluble calcium compound and 1,450 ppm F provide significantly greater protection against caries lesion cavitation, in a low to moderate caries risk population, than dentifrices containing 1,450 ppm F alone.