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Item Metadata only Maeruines A−E, elusive indole alkaloids from stems of Maerua siamensis and their inhibitory effects on cyclooxygenases and HT-29 colorectal cancer cell proliferation(2025-01-01) Nukulkit S.; Nalinratana N.; Aree T.; Suriya U.; Suttisri R.; Nuengchamnong N.; Chang H.S.; Chansriniyom C.; Nukulkit S.; Mahidol University[NMR, MS, IR, and UV], and single-crystal X-ray diffraction. Maeruine D (4) displayed selective cyclooxygenase-2 (COX-2) inhibitory activity in vitro with an IC50 of 29.72 ± 6.36 μM. Molecular dynamics simulations revealed that maeruine D could form aItem Metadata only Boesenbergia rotunda and Its Pinostrobin for Atopic Dermatitis: Dual 5-Lipoxygenase and Cyclooxygenase-2 Inhibitor and Its Mechanistic Study through Steady-State Kinetics and Molecular Modeling(2024-01-01) Liana D.; Eurtivong C.; Phanumartwiwath A.; Liana D.; Mahidol UniversityHuman 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) are potential targets for suppressing pruritic skin inflammation in atopic dermatitis (AD). In addition, Staphylococcus aureus colonization and oxidative stress worsen AD skin conditions. WePublication Metadata only ASPP 092, a phenolic diarylheptanoid from Curcuma comosa suppresses experimentally-induced inflammatory ear edema in mice(2021-10-01) Aporn Chuncharunee; Poonyawee Khosuk; Rajitpan Naovarat; Feroze Kaliyadan; Gopinathan Pillai Sreekanth; Siriraj Hospital; King Faisal Universityof major inflammatory cytokines were analyzed by real-time RT-PCR followed by the immunohistochemistry analysis of cyclooxygenase (COX-2). The topical application of ASPP 092 effectively suppressed the EPP-induced edematous formation in the ear of mice...), interleukin-10 (IL-10), interleukin-1β (IL-1β), and Matrix metalloproteinase-13 (MMP-13). The expressions of cyclooxygenases (COX) including COX-1 and COX-2 were significantly reduced by ASPP 092 treatment. For the first time, our results suggest the efficacyPublication Metadata only Anti-inflammatory and anti-insulin resistance activities of aqueous extract from Anoectochilus burmannicus(2017-05-01) Phatcharaporn Budluang; Pornsiri Pitchakarn; Pisamai Ting; Piya Temviriyanukul; Ariyaphong Wongnoppawich; Arisa Imsumran; Chiang Mai University; Mahidol UniversityRNA and protein expressions of nitric oxide synthase (iNOS). The LPS-induced mRNA expressions of cyclooxygenase-2 (COX-2) and interleukin 1β (IL-1β) were suppressed by ABE. Moreover, ABE exerted anti-insulin resistance activity as it significantly improvedPublication Metadata only Effects of catechin, diclofenac and celecoxib on the proliferation of MCF-7 and LTED MCF-7 cells(2011-07-01) N. Sookvanichsilp; K. Poemsantitham; Mahidol UniversityBreast cancer is common among women especially after menopause. Inflammation is now considered as a risk factor of cancer and cyclooxygenase-2 (COX-2) enzymes are highly expressed in many cancers. COX-2 is the inducible enzyme responsiblePublication Metadata only Punicalagin, a pomegranate compound, induces apoptosis and autophagy in acute leukemia(2021-11-02) Paweena Subkorn; Chosita Norkaew; Kamolchanok Deesrisak; Dalina Tanyong; Mahidol Universityinduced apoptosis through the upregulation of caspase-3/-8/-9, Bax and the downregulation of Bcl-2 expression. Punicalagin also promoted autophagy via the downregulation of mTOR and the upregulation of ULK1 expression. Cyclooxygenase-2 and toll-likePublication Metadata only Bioactive dammarane triterpenes from the mangrove Plant Bruguiera gymnorrhiza(2006-03-01) Sudarat Homhual; Nuntavan Bunyapraphatsara; Tamara Kondratyuk; Angkana Herunsalee; Wongsatit Chaukul; John M. Pezzuto; Harry H S Fong; Hong Jie Zhang; Mahidol University; Purdue University; Thailand Ministry of Public Health; University of Illinois at Chicago) luciferase activation with an IC50 value of 1.4 μM and selectively inhibited cyclooxygenase-2 (COX-2) activity with an IC50 value of 0.37 μM. Compounds 2 and 3 were not active in these bioassays. © 2006 American Chemical Society and American SocietyPublication Metadata only Identification of novel anti-inflammatory peptides from bee pollen (Apis mellifera) hydrolysate in lipopolysaccharide-stimulated RAW264.7 macrophages(2020-01-01) Tanatorn Saisavoey; Papassara Sangtanoo; Chanpen Chanchao; Onrapak Reamtong; Aphichart Karnchanatat; Chulalongkorn University; Mahidol University-inflammatory cytokines including cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor interleukin-6 (IL-6) and necrosis factor transcript expression (TNF-α) in RAW264.7 macrophage cells. Thus, the MW1 fraction was fractionated using reversedPublication Metadata only Orange-fleshed sweet potato (Ipomoea batatas) extract attenuates lipopolysaccharide-induced inflammation in RAW264.7 cells via inactivation of MAPKs and IkB signalling(2019-01-01) Yada Saokosol; Kemika Praengam; Monruedee Sukprasansap; Siriporn Tuntipopipat; Mahidol Universitymedia and cell lysate were collected to measure nitric oxide, interleukin-6 (IL-6), IL-1b, tumour necrosis factor-a, inducible nitric oxide synthase, cyclooxygenase-2, mitogenactivated protein kinases (MAPKs) and inhibitory kappa B (IkB), respectivelyPublication Metadata only Variation of prostaglandin E2concentrations in ovaries and its effects on ovarian maturation and oocyte proliferation in the giant fresh water prawn, Macrobrachium rosenbergii(2015-11-01) Chanudporn Sumpownon; Attakorn Engsusophon; Tanapan Siangcham; Eiji Sugiyama; Nantawan Soonklang; Prasert Meeratana; Chaitip Wanichanon; Peter J. Hanna; Mitsutoshi Setou; Prasert Sobhon; Mahidol University; Faculty of Medicine, Thammasat University; Burapha University; Deakin University; Hamamatsu University School of Medicine, cyclooxygenase1 (COX1) and prostaglandin E synthase (PGES) in the ovarian tissues of M. rosenbergii, using immunohistochemistry. Intense immunoreactivities of PGE2(PGE2-ir), COX1 (Cox1-ir) and PGES (PGES-ir) were detected in previtellogenic oocytes (Oc1 and Oc2