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Publication Metadata only Stress fracture of the femoral shaft in Paget’s disease of bone: A case report(2021-05-01) Sarthak Nepal; Atthakorn Jarusriwanna; Aasis Unnanuntana; Siriraj Hospital; Naresuan Universityat the lateral aspect of the femur, is an uncommon low-trauma fracture frequently seen in association with long-term bisphosphonate therapy. We describe the case of a 61-year-old female patient with PDB who developed a stress fracture at the lateral femoral... visible on the most recent radiograph. Although it remains unclear whether a stress fracture at the lateral femoral cortex occurred due to bisphosphonate therapy or PDB, this case highlights the importance of careful evaluation of any lesion that appearsPublication Metadata only p53 regulates oxidative stress-mediated retrograde signaling: A novel mechanism for chemotherapy-induced cardiac injury(2011-04-07) Joyce M. Velez; Sumitra Miriyala; Ramaneeya Nithipongvanitch; Teresa Noel; Chotiros D. Plabplueng; Terry Oberley; Paiboon Jungsuwadee; Holly van Remmen; Mary Vore; Daret K. St Clair; University of Kentucky College of Medicine; University of Wisconsin Madison; VA Medical Center; Mahidol University; University of Texas Health Science Center at San AntonioThe side effects of cancer therapy on normal tissues limit the success of therapy. Generation of reactive oxygen species (ROS) has been implicated for numerous chemotherapeutic agents including doxorubicin (DOX), a potent cancer chemotherape utic...) and p53 homozygous knock-out (p53 -/- ) mice to investigate the role of p53 in the crosstalk between mitochondria and nucleus. Injecting mice with DOX (20 mg/kg) causes oxidative stress in cardiac tissue as demonstrated by immunogold analysisItem Metadata only Hyperbaric oxygen therapy improves age induced bone dyshomeostasis in non-obese and obese conditions(2022-04-15) Imerb N.; Thonusin C.; Pratchayasakul W.; Arunsak B.; Nawara W.; Aeimlapa R.; Charoenphandhu N.; Chattipakorn N.; Chattipakorn S.C.; Mahidol UniversityAims: To investigate the effects of hyperbaric oxygen therapy (HBOT) on metabolic disturbance, aging and bone remodeling in D-galactose-induced aging rats with and without obesity by determining the metabolic parameters, aging and oxidative stress.../group) for 14 days. Rats were then euthanized. Blood samples, femora, and tibiae were collected. Key findings: Both NDD and HFDD groups developed aging as indicated by increased AGE level, increased inflammation and oxidative stress as shown by raisedPublication Metadata only Mitigation of renal inflammation and endoplasmic reticulum stress by vildagliptin and statins in high-fat high-fructose diet-induced insulin resistance and renal injury in rats(2020-09-01) Laongdao Thongnak; Varanuj Chatsudthipong; Anusorn Lungkaphin; Mahidol University; Chiang Mai University, ER stress, fibrosis and apoptosis. We investigated the effects of a combination treatment of the DPP-4 inhibitor vildagliptin and atorvastatin on renal lipotoxicity related to renal dysfunction and injury in a high-fat high-fructose diet (HFF)-induced... renal lipid accumulation in HFF rats. The reduction in renal lipotoxicity via diminishing renal inflammation, ER stress, fibrosis and apoptosis was also more significant in the combined treatment group than in the other groups in which the drug was usedPublication Metadata only Protection against Oxidative Stress in Beta Thalassemia/Hemoglobin E Erythrocytes by Inhibitors of Glutathione Efflux Transporters(2013-01-31) Chatchai Muanprasat; Chokdee Wongborisuth; Nutthapoom Pathomthongtaweechai; Saravut Satitsri; Suradej Hongeng; Mahidol UniversityIn beta thalassemia/hemoglobin E (Hb E), abnormally high levels of oxidative stress account for accelerated senescence and increased destruction of erythrocytes. The present study aimed to investigate the role of glutathione efflux transporters... by ~80% and 50%, respectively. Furthermore, combined treatment with GlyH-101 and MK571 completely abolished the induction of reactive oxygen radicals. Increased oxidative stress in the erythrocytes following H2O2challenges was accompanied by a decreasePublication Metadata only Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites(2018-03-01) Frances Rocamora; Lei Zhu; Kek Yee Liong; Arjen Dondorp; Olivo Miotto; Sachel Mok; Zbynek Bozdech; Columbia University Medical Center; University of Oxford; Mahidol University; Nanyang Technological University© 2018 Rocamora et al. Due to their remarkable parasitocidal activity, artemisinins represent the key components of first-line therapies against Plasmodium falciparum malaria. However, the decline in efficacy of artemisinin-based drugs jeopardizes... indicate that enhanced adaptive responses against oxidative stress and protein damage are associated with decreased artemisinin susceptibility. This corroborates our previous findings implicating these cellular functions in artemisinin resistance in naturalPublication Metadata only A combination of an iron chelator with an antioxidant exerts greater efficacy on cardioprotection than monotherapy in iron-overload thalassemic mice(2018-01-02) Sirinart Kumfu; Juthamas Khamseekaew; Siripong Palee; Somdet Srichairatanakool; Suthat Fucharoen; Siriporn C. Chattipakorn; Nipon Chattipakorn; Mahidol University; Chiang Mai Universitycardiomyopathy in animal models. Interestingly, a therapy including the combination of the iron chelator deferiprone (DFP) plus the antioxidant N-acetylcysteine (NAC) has been shown to significantly decrease oxidative stress and restore heart and brain function...© 2017 Informa UK Limited, trading as Taylor & Francis Group. Many recent studies have shown that antioxidant compounds decrease cardiac oxidative stress, decrease cardiac iron deposition, and improve cardiac dysfunction in iron-overload inducedPublication Metadata only Effect of coenzyme Q10as an antioxidant in β-thalassemia/ Hb E patients(2005-01-01) Ruchaneekorn W. Kalpravidh; Angkana Wichit; Noppadol Siritanaratkul; Suthat Fucharoen; Mahidol University; The Institute of Science and Technology for Research and Development, Mahidol University-thalassemia/ HbE are prone to increased oxidative stress as indicated by increased lipid peroxidation product, malondialdehyde (MDA), partly because of the presence of iron in the form of heme and hemichromes released from excess globin chains and excess iron... that the levels of coenzyme Q10(CoQ10) are also very low in thalassemia. We therefore evaluated the oxidative stress and the antioxidants in these patients before and after supplementation with 100 mg CoQ10daily for 6 months. The results showed that the plasmaPublication Metadata only Biomarkers in stress related diseases/disorders: Diagnostic, prognostic, and therapeutic values(2019-01-01) Kuldeep Dhama; Shyma K. Latheef; Maryam Dadar; Hari Abdul Samad; Ashok Munjal; Rekha Khandia; Kumaragurubaran Karthik; Ruchi Tiwari; Mohd Iqbal Yatoo; Prakash Bhatt; Sandip Chakraborty; Karam Pal Singh; Hafiz M.N. Iqbal; Wanpen Chaicumpa; Sunil Kumar Joshi; Razi Vaccine & Serum Research Institute, Iran; Tamilnadu Veterinary Animal Sciences University; Barkatullah University; University of Miami Leonard M. Miller School of Medicine; Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir; College of Veterinary Science India; Govind Ballabh Pant University of Agriculture and Technology; Faculty of Medicine, Siriraj Hospital, Mahidol University; Tecnologico de Monterrey; Indian Veterinary Research Institute; College of Veterinary Sciences and Animal Husbandry, and chemical secretions in the saliva and urine. In addition, stress biomarkers also play critical roles in the prognosis of stress-related diseases and disorders, and therapy guidance. Moreover, different components have been identified as potent mediators... to the whole-body level, inducing the so-called state of stress. Stress affects an organism’s welfare status and induces energy-consuming mechanisms to combat the subsequent ill effects; thus, the individual may be immunocompromised, making them vulnerablePublication Metadata only Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling(2016-02-01) Sumitra Miriyala; Chadinee Thippakorn; Luksana Chaiswing; Yong Xu; Teresa Noel; Artak Tovmasyan; Ines Batinic-Haberle; Craig W. Vander Kooi; Wang Chi; Ahmed Abdel Latif; Manikandan Panchatcharam; Virapong Prachayasittikul; D. Allan Butterfield; Mary Vore; Jeffrey Moscow; Daret K.St Clair; University of Kentucky; Louisiana State University in Shreveport; Mahidol University; University of Wisconsin Madison; Duke University Medical Center; University of Kentucky HealthCarerole of HNE with important consequences for mitochondrial stress signaling, heart failure, and the side effects of cancer therapy....© 2015 Elsevier Inc. All rights reserved. Cardiovascular complications are major side effects of many anticancer drugs. Accumulated evidence indicates that oxidative stress in mitochondria plays an important role in cardiac injury, but how