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Subject: Chemistry

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    Cyclodextrin-integrated molecularly imprinted polymer-based QCM sensor for sensitive, label-free detection of Gal3
    (2025-11-01) Longsompurana P.; Wolschann P.; Subannajui K.; Lieberzeit P.A.; Poo-arporn R.P.; Longsompurana P.; Mahidol University
    and morbidity associated with HF, early diagnosis is critical, necessitating a rapid, sensitive, and straightforward method for Gal3 detection. This study presents an innovative, label-free quartz crystal microbalance (QCM) sensor designed for Gal3 detection... dissociation constant (KD) of 2.03 nM. This indicates a stronger binding affinity compared to the non-molecularly imprinted polymer (NIP), which exhibited a KD of 26.75 nM. The sensor exhibits a linear detection range of 1–30 ng/mL, with a
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    Nanocomposite-based all-in-one electrode coating towards affinity-based electrochemical biosensing platform
    (2026-06-01) Tungtrakarnkul P.; Kumar R.K.R.; Bharti A.M.; Lawaniya S.D.; Hu W.C.; Chuang C.H.; Huang S.F.; Wu K.C.W.; Lertanantawong B.; Tungtrakarnkul P.; Mahidol University
    The commercialization of affinity-based electrochemical point-of-care devices remain constrained by their reliance on external redox mediators and the longstanding challenge of simultaneously achieving high signal sensitivity and antifouling... (BSA) carboxyl groups. As a proof-of-concept, an epithelial cell adhesion molecule (EpCAM)-specific aptamer (Apt-NH₂) was designed and immobilized for label-free detection of M D Anderson-Metastatic Breast −231 (MDA-MB-231) breast cancer cells
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    SERS-based immunoassay on 2D-arrays of Au@Ag core-shell nanoparticles: influence of the sizes of the SERS probe and sandwich immunocomplex on the sensitivity
    (2017-01-01) Kullavadee Karn-Orachai; Kenji Sakamoto; Rawiwan Laocharoensuk; Suwussa Bamrungsap; Tararaj Dharakul; Kazushi Miki; National Institute for Materials Science Tsukuba; University of Tsukuba; Thailand National Science and Technology Development Agency; Mahidol University
    © The Royal Society of Chemistry. We report a sandwich-type SERS-based immunoassay using a two-dimensional (2D) array of gold core@silver shell (Au@Ag) nanoparticles (NPs) as the SERS substrate and antibody-conjugated gold NPs labeled with 4... by adopting an antibody-fragment with the same affinity for the target antigen as that of the antibody.
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    Facile and Unplugged Surface Plasmon Resonance Biosensor with NIR-Emitting Perovskite Nanocomposites for Fast Detection of SARS-CoV-2
    (2023-01-01) Chen L.C.; Li M.C.; Chen K.R.; Cheng Y.J.; Wu X.Y.; Chen S.A.; Youh M.J.; Kuo C.C.; Lin Y.X.; Lin C.Y.; Wang C.F.; Huang C.F.; Lin S.Y.; Wang W.H.; Chen Y.H.; Yu M.L.; Thitithanyanont A.; Wang S.F.; Su L.C.; Mahidol University
    The emergence of the coronavirus disease 2019 (COVID-19) pandemic prompted researchers to develop portable biosensing platforms, anticipating to detect the analyte in a label-free, direct, and simple manner, for deploying on site to prevent.... In addition, the bio-applicability of the platform was validated by incorporating a homemade high-affinity polyclonal antibody toward the SARS-CoV-2 spike protein. The results demonstrated that the proposed system was capable of discriminating between clinical