17 results
Search Results
Now showing 1 - 10 of 17
Item Metadata only Transcriptomic analysis of DENV-2-infected human dermal fibroblasts identified potential mechanisms that suppressed ZIKV replication during sequential coinfection(2025-12-01) Kaofai C.; Jearanaiwitayakul T.; Saisingha K.; Limthongkul J.; Masrinoul P.; Ubol S.; Kaofai C.; Mahidol Universitysequential coinfection revealed that prior DENV-2 infection significantly suppressed ZIKV RNA accumulation in the culture supernatant. Transcriptomic profile in response to DENV-2 infection suggested three hypothetical pathways that potentially interferePublication Metadata only A Novel Sub-Lineage of Chikungunya Virus East/Central/South African Genotype Indian Ocean Lineage Caused Sequential Outbreaks in Bangladesh and Thailand(2020-11-17) Juthamas Phadungsombat; Hisham Imad; Mizanur Rahman; Emi E. Nakayama; Sajikapon Kludkleeb; Thitiya Ponam; Rummana Rahim; Abu Hasan; Kanaporn Poltep; Atsushi Yamanaka; Wasin Matsee; Watcharapong Piyaphanee; Weerapong Phumratanaprapin; Tatsuo Shioda; Apollo Hospitals Dhaka; Research Institute for Microbial Diseases; The Hospital for Tropical Diseases, Bangkok; Mahidol Universityfull genomes were sequenced. Phylogenetic analysis revealed that the recent CHIKVs were of Indian Ocean Lineage (IOL) of genotype ECSA, similar to the previous outbreak. However, these CHIKVs were all clustered into a new distinct sub-lineage apart from... at position 211 of E1 and valine-to-alanine at position 264 of E2. Molecular clock analysis suggested that the new sub-lineage CHIKV was introduced to Bangladesh around late 2015 and Thailand in early 2017. These results suggest that re-emerged CHIKVs havePublication Metadata only Artesunate and mefloquine given simultaneously for three days via a prepacked blister is equally effective and tolerated as a standard sequential treatment of uncomplicated acute Plasmodium falciparum malaria: Randomized, double-blind study in Thailand(2002-11-01) S. Krudsood; S. Looareesuwan; U. Silachamroon; K. Chalermrut; D. Pittrow; N. Cambon; E. A. Mueller; Mahidol University; Technische Universitat Dresden; Mepha Ltd; Dresden University Faculty of Medicine and University Hospital Carl Gustav Carusdose = 25 mg/kg, ∼8.5 mg/kg/day, simultaneously. Group B received artesunate, 4-5 mg/kg/day, and mefloquine, total dose = 25 mg/kg, sequentially (i.e., no mefloquine dose on the first day, 15 mg/kg on the second day, and 10 mg/kg on the third day). Both... treatment groups showed no relevant differences in baseline demographic and clinical characteristics. Intent-to-treat analysis revealed a cure rate at day 28 (primary endpoint) of 100% in group A and 99% in group B (difference not significant). The secondaryPublication Metadata only The probability of a sequential Plasmodium vivax infection following asymptomatic Plasmodium falciparum and P. vivax infections in Myanmar, Vietnam, Cambodia, and Laos(2019-12-30) Lorenz Von Seidlein; Pimnara Peerawaranun; Mavuto Mukaka; Francois H. Nosten; Thuy Nhien Nguyen; Tran Tinh Hien; Rupam Tripura; Thomas J. Peto; Tiengkham Pongvongsa; Koukeo Phommasone; Mayfong Mayxay; Mallika Imwong; James Watson; Sasithon Pukrittayakamee; Nicholas P.J. Day; Arjen M. Dondorp; Mahidol University; Nuffield Department of Clinical Medicine; Amsterdam UMC - University of Amsterdam; oyal Society of Thailand; University of Health Sciences; AHTC; Mahosot Hospital; Savannakhet Provincial Health Department; Oxford University Clinical Research Unit; Shoklo Malaria Research InstitutePlasmodium falciparum and P. vivax infections. Results: 16,959 valid sequential paired test results were available for analysis. Of these, 534 (3%) had an initial P. falciparum monoinfection, 1169 (7%) a P. vivax monoinfection, 217 (1%) had mixed (P... under a universal radical cure policy using 8-aminoquinoline needs to be weighed against the benefit of preventing repeated vivax episodes. Estimating the frequency of sequential Plasmodium vivax infections following either falciparum or vivax malariaPublication Metadata only Identification of differentially expressed proteins from Burkholderia pseudomallei isolated during primary and relapsing melioidosis(2012-04-01) Billie Velapatiño; Direk Limmathurotsakul; Sharon J. Peacock; David P. Speert; The University of British Columbia; Mahidol University; University of CambridgeBurkholderia pseudomallei causes septicemic melioidosis with a high rate of relapse, however microbial determinants of relapse are unknown. Proteins were analyzed from sequential B. pseudomallei isolates from primary and relapsing melioidosis.... Analysis by isotope tagging for relative and absolute quantitation revealed that factors required for nitric oxide detoxification (HmpA) and necessary for anaerobic growth (ArcA, ArcC and ArcB) were highly expressed in the relapse isolate. Two-dimensionalPublication Metadata only In-hospital death after septic shock reversal: A retrospective analysis of in-hospital death among septic shock survivors at Thailand's largest national tertiary referral center(2021-01-06) Chairat Permpikul; Chaisith Sivakorn; Surat Tongyoo; Siriraj Hospital; Faculty of Tropical Medicine, Mahidol Universityand required more organ support, there were four factors associated with mortality from multivariate analysis. Hospital-acquired pneumonia was the leading factor, followed by sequential organ failure assessment score and serum albumin at 72 hours afterPublication Metadata only Transcriptome profiling and functional analysis of Agrobacterium tumefaciens reveals a general conserved response to acidic conditions (pH 5.5) and a complex acid-mediated signaling involved in Agrobacterium-plant interactions(2008-01-01) Ze Chun Yuan; Pu Liu; Panatda Saenkham; Kathleen Kerr; Eugene W. Nester; University of Washington, Seattle; Seattle Biomedical Research Institute; Mahidol UniversityAgrobacterium tumefaciens transferred DNA (T-DNA) transfer requires that the virulence genes (vir regulon) on the tumor-inducing (Ti) plasmid be induced by plant phenolic signals in an acidic environment. Using transcriptome analysis, we found... involved in Agrobacterium-plant interactions. Overall, 78 genes were induced and 74 genes were repressed significantly under acidic conditions (pH 5.5) compared to neutral conditions (pH 7.0). Microarray analysis not only confirmed previously identifiedPublication Metadata only An in-depth analysis of original antigenic sin in dengue virus infection(2011-01-01) Claire M. Midgley; Martha Bajwa-Joseph; Sirijitt Vasanawathana; Wannee Limpitikul; Bridget Wills; Aleksandra Flanagan; Emily Waiyaiya; Hai Bac Tran; Alison E. Cowper; Pojchong Chotiyarnwon; Jonathan M. Grimes; Sutee Yoksan; Prida Malasit; Cameron P. Simmons; Juthathip Mongkolsapaya; Gavin R. Screaton; Imperial College London; Khon Kaen Regional Hospital; Songkhla Hospital; UCL; Wellcome Trust Centre for Human Genetics; Mahidol University; Thailand National Center for Genetic Engineering and BiotechnologyThe evolution of dengue viruses has resulted in four antigenically similar yet distinct serotypes. Infection with one serotype likely elicits lifelong immunity to that serotype, but generally not against the other three. Secondary or sequential... performed a detailed analysis of the anti-ED3 response in a cohort of patients suffering either primary or secondary dengue infections. The results show dramatic evidence of original antigenic sin in secondary infections both in terms of bindingPublication Metadata only Approach toward enhancement of halophilic protease production by Halobacterium sp. strain LBU50301 using statistical design response surface methodology(2016-06-01) Julalak Chuprom; Preeyanuch Bovornreungroj; Mehraj Ahmad; Duangporn Kantachote; Sawitree Dueramae; Prince of Songkla University; Mahidol University© 2016 The Author. Published by Elsevier B.V. A new potent halophilic protease producer, Halobacterium sp. strain LBU50301 was isolated from salt-fermented fish samples (budu) and identified by phenotypic analysis, and 16S rDNA gene sequencing.... Thereafter, sequential statistical strategy was used to optimize halophilic protease production from Halobacterium sp. strain LBU50301 by shake-flask fermentation. The classical one-factor-at-a-time (OFAT) approach determined gelatin was the best nitrogenPublication Metadata only Developing the Thai Siriraj Psoriatic Arthritis Screening Tool and validating the Thai Psoriasis Epidemiology Screening Tool and the Early Arthritis for Psoriatic Patients questionnaire(2016-10-01) Praveena Chiowchanwisawakit; Luksame Wattanamongkolsil; Varalak Srinonprasert; Chonachan Petcharat; Palanan Siriwanarangsun; Wanruchada Katchamart; Mahidol Universitythe performances of the tools. The Siriraj Psoriatic Arthritis Screening Tool (SiPAT) contained questions most relevant to peripheral arthritis, axial inflammation, and enthesitis, selected from multivariate analysis. Of a total of 159 patients, the prevalence.... Thai PEST and EARP could possibly be sequentially administered for people with a positive test from SiPAT to reduce the number of false positives.