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Publication Open Access The Effects of a Constipation Prevention Program on Incidence and Severity of Constipation in Hospitalized Elderly undergoing Hip Surgery(2011) พวงผกา มั่นหมาย; Poungpaka Monmai; สุภาพ อารีเอื้อ; Suparb Aree-Ue; พรรณวดี พุธวัฒนะ; Panwadee Putwatana; วิโรจน์ กวินวงศ์โกวิท; Viroj Kawinwonggowit; มหาวิทยาลัยมหิดล. คณะแพทยศาสตร์โรงพยาบาลรามาธิบดี. ภาควิชาออร์โธปิดิกส์; มหาวิทยาลัยมหิดล. คณะแพทยศาสตร์โรงพยาบาลรามาธิบดี. โรงเรียนพยาบาลรามาธิบดี; มหาวิทยาลัยมหิดล. โรงพยาบาลรามาธิบดี. ฝ่ายการพยาบาลPurpose: To examine the effects of constipation prevention program on incidence and severity ofconstipation in hospitalized elderly undergoing hip surgery. Design: Quasi-experimental design. Methods: The sample consisted of 60 hospitalized... was effective in reducing the incidence and severity ofconstipation. The program should be recommended as a tool to improve quality of care for hospitalizedelderly who are at risk of developing constipation.Publication Open Access Effects of alcoholic extract from pomegranate (Punica granatum L.) peels on gastrointestinal nematode egg counts in doe(2013) Sookruetai Boonmasawai; Sivapong Sungpradit; Charoonluk Jirapattharasate; Chowalit Nakthong; Lak Piasai; Mahidol University. Faculty of Veterinary Science. Department of Pre-clinic and Applied Animal Science; Mahidol University. Faculty of Veterinay Science. Department of Clinical Sciences and Public HealthAnthelmintic drug resistant is one of the major problem that quietly reflecting the small ruminant production qualities. Because this problem recently spread out in many areas all over the world, the alternative anthelmintic methods are recently... activity of alcoholic extract from pomegranate peels against female goat gastrointestinal nematodes and the toxic effects after treatments. The results were shown that albendazole and pomegranate peel powder could not affect percent of strongyle egg perPublication Open Access Population pharmacokinetic properties of artemisinin in healthy male Vietnamese volunteers(2016) Sofia Birgersson; Pham Van Toi; Nguyen Thanh Truong; Nguyen Thi Dung; Michael Ashton; Tran Tinh Hien; Angela Abelö; Joel Tarning; Mahidol University. Faculty of Tropical Medicine. Mahidol‑Oxford Tropical Medicine Research UnitBackground: Artemisinin-based combination therapy is recommended as first-line anti-malarial treatment worldwide. A combination of artemisinin with the long acting drug piperaquine has shown high efficacy and tolerability in patients... to 12 h after dose in each period. Artemisinin was quantified in plasma using liquid chromatography coupled with tandem mass spectrometry. A nonlinear mixed-effects modelling approach was utilized to evaluate the population pharmacokinetic propertiesPublication Open Access Linalool, derived from Cinnamomum camphora (L.) Presl leaf extracts, possesses molluscicidal activity against Oncomelania hupensis and inhibits infection of Schistosoma japonicum.(2014-08-29) Yang, Fan; Long, Erping; Wen, Juhua; Cao, Lei; Zhu, Chengcheng; Hu, Huanxin; Ruan, Ying; Kamolnetr Okanurak; กมลเนตร โอฆานุรักษ์; Hu, Huiling; Wei, Xiaoxia; Yang, Xiangyun; Wang, Chaofan; Zhang, Limei; Wang, Xiaoying; Ji, Pengyu; Zheng, Huanqin; Wu, Zhongdao; Lv, Zhiyue; Wu, Zhongdao; Lv, Zhiyue; Mahidol University. Faculty of Tropical Medicine. Department of Social and Environmental Medicine.associated with severe side effects. Previous studies have demonstrated that linalool-rich extracts from various plants exhibited promising biological activities including cytotoxic, anti-microbial and anti-parasitic properties. METHODS: We identified... the components of leaf extracts from Cinnamomum camphora by gas chromatography coupled to mass spectrometry (GC-MS) and investigated molluscicidal and larvicidal effects of linalool against O. hupensis and Schistosoma japonicium. The ultrastructural alterationsPublication Open Access P-Glycoprotein transporter in drug development(2016-02-12) Veda Prachayasittikul; Virapong Prachayasittikul; Mahidol University. Faculty of Medical Technology. Department of Clinical Microbiology and Applied TechnologyPublication Open Access Hydroxyurea and colonic ulcers: a case report(2014) Kochawan Boonyawat; Sansanee Wongwaisayawan; Prawat Nitiyanant; Vichai Atichartakarn; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Department of PathologyBackground: Hydroxyurea at a relatively low dose is frequently prescribed to induce hemoglobin F production in patients with sickle cell and β-thalassemia diseases because of its good efficacy and safety profiles. However, a potentially fatal gastrointestinal ulceration was recently found and herein reported. Case presentation: A thirty-seven-year-old man with transfusion dependent hemoglobin E/β-thalassemia disease was treated with hydroxyurea to induce hemoglobin F production since 2007 without incident. From 2008 to April 2010, episodes of hematochezia, mucous diarrhea and epigastric pain intermittently manifested. Four colonoscopies done during the period repeatedly showed ulcerative lesions from the terminal ileum to the ascending colon with a non-specific histo-pathologic finding. Subsequently, ulcerative lesions also developed at the pharynx, histo-pathologic findings of which were not different from those in the colon. These ulcerative lesions resolved within a month after discontinuing hydroxyurea in April 2010 and have not recurred since. Conclusion: The findings suggested role of hydroxyurea in the pathogenesis of these ulcers, and that it must be immediately discontinued to prevent further damage to the digestive mucosa.Publication Open Access Mitogen-activated protein kinase p38b interaction with delta class glutathione transferases from the fruit fly, Drosophila melanogaster(2012) Jeerang Wongtrakul; Suchada Sukittikul; Chonticha Saisawang; Ketterman, Albert J.; Mahidol University. Institute of Molecular BiosciencesGlutathione transferases (GSTs) are a family of multifunctional enzymes involved in xenobiotic biotransformation, drug metabolism, and protection against oxidative damage. The p38b mitogen–activated protein kinase is involved in cellular stressPublication Open Access A case report of intravenous posaconazole in hepatic and renal impairment patient with invasive Aspergillus terreus infection: safety and role of therapeutic drug monitoring(2017) Pitchaya Dilokpattanamongkol; Panadda Panusitthikorn; Rasda Boonprasert; Methee Chayakulkeeree; Porpon Rotjanapan; Mahidol University. Faculty of Pharmacy. Department of Pharmacy; Mahidol University. Faculty of Medicine, Siriraj Hospital. Department of Pharmacy; Mahidol University. Faculty of Medicine, Siriraj Hospital. Clinical Toxicology Laboratory, Siriraj Poison Control Center; Mahidol University. Faculty of Medicine, Siriraj Hospital. Division of Infectious Diseases and Tropical Medicine.; Mahidol University. Department of Medicine, Ramathibodi Hospital. Division of Infectious Diseasesinfection. To our knowledge, this is the first report of intravenous posaconazole use in IA due to A. terreus with hepatic and renal impairment focusing on drug safety and role of therapeutic drug monitoring (TDM). Case presentation: A 37-year-old... of potential adverse effects whilst on intravenous voriconazole, intravenous posaconazole 300 mg every 48 h was chosen with confirmed therapeutic plasma concentrations. Despite the death of the patient and IA deemed uncontrollable, there were no significantPublication Open Access Dabigatran: A new oral anticoagulant(2015-01) Sirada Srihirun; สิรดา ศรีหิรัญ; Nathawut Sibmooh; ณัฐวุธ สิบหมู่; Sirada Srihirun; สิรดา ศรีหิรัญ; Mahidol University. Faculty of Dentistry. Department of Pharmacology; Mahidol University. Faculty of Science. Department of PharmacologyDabigatran, a direct thrombin inhibitor (DTI), has been approved as a new orally administrated anticoagulant in many countries including Thailand. Food and drug administration (FDA) Thailand has approved 75, 110 and 150 mg of dabigatran since 2009..., pharmacokinetics, pharmacodynamics, clinical trials, and adverse effects. In addition, the suggestion for dental management of patients being treated with dabigatran has been stated.Publication Open Access World Antimalarial Resistance Network (WARN) IV: clinical pharmacology(2007-09-06) Barnes, Karen I.; Lindegardh, Niklas; Ogundahunsi, Olumide; Olliaro, Piero; Plowe, Christopher V.; Randrianarivelojosia, Milijaona; Gbotosho, Grace O; Watkins, William M.; Sibley, Carol H.; White, Nicholas J.; Barnes, Karen I.; Mahidol University. Faculty of Tropical Medicine. Mahidol Oxford Tropical Medicine Research Unit (MORU).A World Antimalarial Resistance Network (WARN) database has the potential to improve the treatment of malaria, through informing current drug selection and use and providing a prompt warning of when treatment policies need changing... should contribute to improving the quantity, relevance and quality of these studies. A better understanding of the pharmacokinetic properties of antimalarials and a more clear definition of what constitutes "therapeutic drug levels" would allow more