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Publication Open Access Estrogen Deficiency Leads to Further Bone Loss in the Mandible of CKD Mice.(2016-02-17) Dutmanee Seriwatanachai; ดุษมณี เสรีวัฒนาชัย; Guo, Yuchen; Sun, Ningyuan; Duan, Xiaobo; Xu, Xin; Zheng, Liwei; Wang, Yongyue; Yuan, Quan; Mahidol University. Faculty of Dentistry. Department of Oral Biologynephrectomy and ovariectomy (OVX), respectively. After 8 weeks, the mice were sacrificed, and their mandibles were collected for micro-CT analysis and histological examination. RESULTS: All the mice survived the experimental period. Serum measurements... that estrogen deficiency leads to further mandibular bone loss in CKD mice.Publication Open Access A Thailand case study based on quantitative assessment: does a national lead agency make a difference in pre-hospital care development in middle income countries?(2014) Paibul Suriyawongpaisal; Wichai Aekplakorn; Rassamee Tansirisithikul; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Department of Community MedicineBackground: Emergency Medical Institute of Thailand (EMIT) has been established as a national lead agency to improve emergency medical service systems since December 2008. However up to now, there has not been any published systematic assessment...-hospital care i.e., Information Technology for Emergency Medical Service System (ITEMS) in 2012. Results: Comparing with historical data, we found evidence indicating the national lead agency making differences in two basic requirements of pre-hospitalPublication Open Access Lead exposure and blood lead level of workers in a battery manufacturing plant in Thailand(2003) Chalermchai Chaikittiporn; Srirat Lormphongs; Miyashita, Kazuhisa; Morioka, Ikuharu; Miyai, Nobuyuki; Yamamoto, Hiroichi; Mahidol University. Faculty of Public Health. Department of Occupational Health and SafetyThis study was conducted in a battery manufacturing plant where lead was used in the processes of production, to survey the working conditions and safety behaviors, and to measure the airborne lead level contaminated in the workplace and the blood... lead level of workers. The survey of working conditions showed that the workers were directly exposed to lead in sections e.g. grid casting, spreading, forming and polishing, assembly and special battery production sections. Some workersPublication Open Access Neonatal intrahepatic cholestasis caused by citrin deficiency: prevalence and SLC25A13 mutations among thai infants(2012) Suporn Treepongkaruna; Suttiruk Jitraruch; Porawee Kodcharin; Dussadee Charoenpipop; Pim Suwannarat; Paneeya Pienvichit; Keiko Kobayashi; Duangrurdee Wattanasirichaigoon1; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Department of Pediatricscaused by citrin deficiency (NICCD) especially, in East Asian populations are increasingly being identified. Since most NICCD infants recovered from liver disease by 1 year of age, they often are misdiagnosed with INH, leading to difficulty... in determining the true prevalence of NICCD. Mutation(s) of human SLC25A13 gene encoding a mitochondrial aspartate/glutamate carrier isoform 2 (AGC2), can lead to AGC2 deficiency, resulting in NICCD and an adult-onset fatal disease namely citrullinemia type IIPublication Open Access การปนเปื้อนของโลหะหนัก โครเมียม แคดเมียม ตะกั่ว ปรอท และสารหนู ในโซ่อีลาสโตเมอร์จัดฟัน(2012-01) ฤดี สุราฤทธิ์; Rudee Surarit; วิทยา วสุเมธารัศมี; Witthaya Wasumaetharatsamee; สมพร เรืองผกา; Somporn Raungpaka; พาสน์ศิริ นิสาลักษณ์; Passiri Nisalak; ภูมิภดา จาวจักรศิริ; Poompada Jaochakarasiri; ฤดี สุราฤทธิ์; Rudee Surarit; มหาวิทยาลัยมหิดล. คณะทันตแพทยศาสตร์. ภาควิชาชีววิทยาช่องปาก; มหาวิทยาลัยมหิดล. คณะทันตแพทยศาสตร์. สาขาทันตกรรมจัดฟัน; มหาวิทยาลัยมหิดล. คณะทันตแพทยศาสตร์. ภาควิชาทันตกรรมจัดฟันObjective: The purpose of this study was to investigate whether any heavy metals, such as Chromium (Cr), Cadmium (Cd), Lead (Pb), Mercury (Hg) or Arsenic (As) contaminated or are released from orthodontic elastomeric chains. Materials... passed through 84 cycles of pH-cycling and 980 cycles of thermo-cycling to mimic the oral environment of 28 days. After completing all processes, artificial saliva was collected for analysis of heavy metal (Cr, Cd, Pb, Hg and As) by atomic absorptionPublication Open Access Transcriptional regulation of the human manganese superoxide dismutase gene: the role of specificity protein 1 (Sp1) and activating protein-2 (AP-2)(2002) Yong XU; Sureerut Porntadavity; Daret K St Clairfor the regulation of MnSOD expression, multiple transcription factor-binding motifs containing overlapping specificity protein 1 (Sp1)- and activator protein (AP)-2-binding sites were identified by DNase I footprinting analysis. Functional studies in three cell... in an increase in the transcription of the promoter-driven reporter gene. In contrast, co-transfection of the AP-2 expression vector caused a decrease in transcription. Direct mutagenesis analysis of Sp1- and AP-2-binding sites showed that Sp1 is essentialPublication Open Access Comparative plasma protein profiling of hemoglobin H disease(2014) Kamonlak Leecharoenkiat; Wannapa Sornjai; Kornpat Khungwanmaythawee; Atchara Paemanee; Chartchai Chaichana; Sittiruk Roytrakul; Suthat Fucharoen; Saovaros Svasti; Smith, Duncan R.; Mahidol University. Institute of Molecular Biosciences. Levels of haptoglobin, a hemoglobin scavenging protein, were significantly increased in HbH patients as compared to HbH-CS patients. The identification of differentially expressed proteins may lead to a better understanding of the biological eventsPublication Open Access Identification and key management of non-transfusion-dependent thalassaemia patients: not a rare but potentially under-recognised condition(2014) Vip Viprakasit; Tyan, Paul; Sarayuth Rodmai; Taher, Ali T.; Mahidol University. Faculty of Medicine, Siriraj Hospital. Department of Pediatrics and Thalassemia Centerspleen and/or liver, skeletal deformities, growth retardation, elevated serum ferritin and iron overload. The contributing factors to disease progression are ineffective erythropoiesis and increased haemolysis, which lead to chronic anaemia. The body’s... attempts to correct the anaemia result in constantly activated erythropoiesis, leading to marrow expansion and extramedullary haematopoiesis. Diagnosis of NTDT is largely clinical but can be confirmed by genetic sequencing. NTDT must be differentiatedPublication Open Access A potential role for interleukin‑33 and γ‑epithelium sodium channel in the pathogenesis of human malaria associated lung injury(2015) Sumate Ampawong; Urai Chaisri; Parnpen Viriyavejakul; Panote Prapansilp; Grau, Georges E; Turner, Gareth D. H.; Emsri Pongponratn; Mahidol University. Faculty of Tropical Medicine. Department of Tropical Pathology, and correlated these with clinical history in groups with or without PE. To investigate the expression of mediators that may influence fluid accumulation in PE, immunohistochemistry and image analysis were performed on controls and sub-sets of patient... cytokeratin levels were similar between groups. Conclusions: The results suggest that IL-33 may play a role in lung injury during severe malaria and lead to PE. Both VSMC and bronchial γ-ENaC downregulation may explain pulmonary fluid disturbancesPublication Open Access Is using multiple imputation better than complete case analysis for estimating a prevalence (risk) difference in randomized controlled trials when binary outcome observations are missing?(2016) Mukaka, Mavuto; White, Sarah A.; Terlouw, Dianne J.; Victor Mwapasa; Linda Kalilani-Phiri; Faragher, E. Brian; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research UnitBackground: Missing outcomes can seriously impair the ability to make correct inferences from randomized controlled trials (RCTs). Complete case (CC) analysis is commonly used, but it reduces sample size and is perceived to lead to reduced