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    PublicationOpen Access
    Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006.
    (2010-03) Fried, Jessica R.; Gibbons, Robert V.; Siripen Kalayanarooj; Thomas, Stephen J.; Anon Srikiatkhachorn,; Yoon, In-Kyu; Jarman, Richard G.; Green, Sharone; Rothman, Alan L.; Cummings, Derek A. T.; Fried, Jessica R.; Mahidol University. Faculty of Tropical Medicine. Mahidol Oxford Tropical Medicine Research Unit (MORU).
    Background It is unclear whether dengue serotypes differ in their propensity to cause severe disease. We analyzed differences in serotype-specific disease severity in children presenting for medical attention in Bangkok, Thailand. Methodology.../Principal Findings Prospective studies were conducted from 1994 to 2006. Univariate and multivariate logistic and multinomial logistic regressions were used to determine if dengue hemorrhagic fever (DHF) and signs of severe clinical disease (pleural effusion
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    PublicationOpen Access
    Genetic modifiers of Hb E/β0 thalassemia identified by a two-stage genome-wide association study
    (2010) Richard Sherva; Orapan Sripichai; Kenneth Abel; Qianli Ma; Johanna Whitacre; Vach Angkachatchai; Wattanan Makarasara; Pranee Winichagoon; Saovaros Svasti; Suthat Fucharoen; Andreas Braun; Lindsay A Farrer; Mahidol University. Institute of Molecular Biosciences. Thalassemi a Research Center; Mahidol University. Faculty of Science. Department of Biochemistry
    Background Patients with Hb E/β0 thalassemia display remarkable variability in disease severity. To identify genetic modifiers influencing disease severity, we conducted a two-stage genome scan in groups of 207 mild and 305 severe unrelated... associated with disease severity (P < 0.05) after Bonferroni adjustment for multiple testing. Forty-one SNPs in a large LD block within the β-globin gene cluster had major alleles associated with severe disease. The most significant was bthal_bg200 (odds
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    PublicationOpen Access
    Clinical severity of β-thalassaemia/Hb E disease is associated with differential activities of the calpain-calpastatin proteolytic system
    (2012-05) Suriyan Sukati; Saovaros Svasti; Stifanese, Roberto; Averna, Monica; Nantika Panutdaporn; Tipparat Penglong; Melloni, Edon; Suthat Fucharoen; Katzenmeier, Gerd; Mahidol University. Institute of Molecular Biosciences; Mahidol University. Faculty of Science. Department of Biochemistry
    to the activity of calpain protease. The aim of this study was to correlate the activity of calpain and its inhibitor, calpastatin, with different degrees of disease severity in β-thalassaemia. CD34+ cells were enriched from peripheral blood of healthy individuals... (control group) and patients with mild and severe clinical presentations of β0-thalassaemia/Hb E disease. By ex vivo cultivation promoting erythroid cell differentiation for 7 days, proerythroblasts, were employed for the functional characterization
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    PublicationOpen Access
    Identification of clinical factors associated with severe dengue among Thai adults: a prospective study
    (2015) Vipa Thanachartwet; Nittha Oer-areemitr; Supat Chamnanchanunt; Duangjai Sahassananda; Akanitt Jittmittraphap; Plengsakoon Suwannakudt; Varunee Desakorn; Anan Wattanathum; Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicine
    Background: Dengue is the most common mosquito-borne viral disease in humans. Recently, there has been an epidemic shift of dengue from mainly affecting children to affecting more adults with increased severity. However, clinical factors... associated with severe dengue in adults have varied widely between studies. We aimed to identify the clinical factors associated with the development of severe dengue according to the World Health Organization (WHO)’s 2009 definition. Methods: We conducted
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    PublicationOpen Access
    Identification and key management of non-transfusion-dependent thalassaemia patients: not a rare but potentially under-recognised condition
    (2014) Vip Viprakasit; Tyan, Paul; Sarayuth Rodmai; Taher, Ali T.; Mahidol University. Faculty of Medicine, Siriraj Hospital. Department of Pediatrics and Thalassemia Center
    Patients with non-transfusion-dependent thalassaemia (NTDT) have a genetic defect or combination of defects that affect haemoglobin synthesis, but which is not severe enough to require regular blood transfusions. The carrier frequency of NTDT... is high (up to 80% in some parts of the world) but the prevalence of symptomatic patients varies with geography and is estimated to be from 1 in 100,000 to 1 in 100. NTDT has a variable presentation that may include mild to severe anaemia, enlarged
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    PublicationOpen Access
    Diagnostic accuracy of peripheral venous lactate and the 2009 WHO warning signs for identifying severe dengue in Thai adults: a prospective observational study
    (2016) Vipa Thanachartwet; Anan Wattanathum; Oer-areemitr, Nittha; Akanitt Jittmittraphap; Duangjai Sahassananda; Chalida Monpassorn; Manoon Surabotsophon; Varunee Desakorn; Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicine
    Background: Dengue is the most common mosquito-borne viral disease in humans. However, the sensitivities of warning signs (WSs) for identifying severe dengue in adults are low, and the utility of lactate levels for identifying severe dengue... in adults has not been verified. Therefore, we aimed to evaluate the diagnostic accuracy of using peripheral venous lactate levels (PVL), as well as WSs established by the World Health Organization, for identifying severe dengue. Methods: We prospectively
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    PublicationOpen Access
    Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria
    (2009-12-15) Conroy, Andrea L.; Lafferty, Erin I.; Lovegrove, Fiona E.; Srivicha Krudsood; ศรีวิชา ครุฑสูตร; Noppadon Tangpukdee; นพดล ตั้งภักดี; Liles, W. Conrad; Kain, Kevin C.; Kain, Kevin C.; Mahidol University. Faculty of Tropical Medicine.
    the clinical utility of whole blood angiopoietin (ANG) levels as biomarkers of disease severity in Plasmodium falciparum malaria. METHODS: The utility of whole blood ANG levels was examined in Thai patients to distinguish cerebral (CM; n = 87) and severe... accuracy of the ANGs in their ability to distinguish between UM, SM and CM. Cumulative organ injury scores were obtained for patients with severe disease based on the presence of acute renal failure, jaundice, severe anaemia, circulatory collapse or coma
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    PublicationOpen Access
    Inverse association of plasma IgG antibody to aggregatibacter actinomycetemcomitans and high C-reactive protein levels in patients with Metabolic Syndrome and Periodontitis.
    (2016-02-12) Supanee Thanakun; สุพานี ธนาคุณ; Suchaya Pornprasertsuk-Damrongsri; สุชยา ดำรงค์ศรี; Gokyu, Misa; Kobayashi, Hiroaki; Izumi, Yuichi; Mahidol University. Faculty of Dentistry. Department of Oral Medicine and Periodontology; Mahidol University. Faculty of Dentistry. Department of Oral and Maxillofacial Radiology
    . actinomycetemcomitans and P. gingivalis were determined by quantitative real-time polymerase chain reaction. Among 127 individuals aged 35–76 years, 57 participants had metabolic syndrome and severe periodontitis, 25 had metabolic syndrome and an absence of severe... periodontitis, 17 healthy individuals had severe periodontitis, and 28 healthy individuals were without severe periodontitis. Patients with metabolic syndrome had reduced humoral immune response to A. actinomycetemcomitans (p = 0.008), regardless
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    PublicationOpen Access
    Severe vivax malaria: a systematic review and meta-analysis of clinical studies since 1900
    (2014) Rahimi, Bilal Ahmad; Ammarin Thakkinstian; White, Nicholas J; Chukiat Sirivichayakul; Dondorp, Arjen M; Watcharee Chokejindachai; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research Unit
    Background: Malaria caused by Plasmodium vivax was long considered to have a low mortality, but recent reports from some geographical areas suggest that severe and complicated vivax malaria may be more common than previously thought. Methods...: The primary objective of this systematic review and meta-analysis was to describe the reported clinical characteristics and the geographical variation in prevalence of reported severe vivax malaria and its change over time derived from English-language
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    PublicationOpen Access
    Increased fluidity and oxidation of malarial lipoproteins: relation with severity and induction of endothelial expression of adhesion molecules
    (2004-06-25) Nathawut Sibmooh; Paveena Yamanont; Srivicha Krudsood; ศรีวิชา ครุฑสูตร; Wattana Leowattana; วัฒนา เลี้ยววัฒนา; Brittenham, Gary; Sornchai Looareesuwan; ศรชัย หลูอารีย์สุวรรณ; Rachanee Udomsangpetch; Nathawut Sibmooh; Mahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicine. Hospital for Tropical Diseases; Mahidol University. Faculty of Science. Department of Pharmacology; Mahidol University. Faculty of Science. Department of Pathobiology
    lipid profile and existence of oxidized forms of very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL) were investigated in malaria (17 mild and 24 severe patients) and 37 control subjects... by which the degree of oxidation was correlated with severity. Of three lipoproteins from malarial patients, LDL displayed the most pronounced oxidative modification. In addition, oxidized LDL from malaria patients increased endothelial expression