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Publication Open Access The utility of single-balloon enteroscopy for the diagnosis and management of small bowel disorders according to their clinical manifestations: a retrospective review(2013) Varayu Prachayakul; Morakod Deesomsak; Pitulak Aswakul; Somchai Leelakusolvong; Mahidol University. Siriraj Hospital. Department of Internal Medicineenteroscopy. However, the relative clinical advantages of the 2 methods remain controversial. This study therefore aimed to identify the indications for and therapeutic impact of performing single-balloon enteroscopy. Methods: We retrospectively reviewed.... Therapeutic procedures were performed in 11% of patients with GI bleeding and achieved a therapeutic yield of 14.6% with a minor complication rate of 11.7%. Conclusions: Single-balloon enteroscopy was effective for the diagnosis and treatment of small bowelPublication Open Access Roles of D-amino acids on the bioactivity of host defense peptides(2016-04) Hao Li; Nuttapat Anuwongcharoen; Aijaz Ahmad Malik; Chanin Nantasenamat; Mahidol University. Faculty of Medical Technology. Center of Data Mining and Biomedical InformaticsHost defense peptides (HDPs) are positively-charged and amphipathic components of the innate immune system that have demonstrated great potential to become the next generation of broad spectrum therapeutic agents effective against a vast array... of pathogens and tumor. As such, many approaches have been taken to improve the therapeutic efficacy of HDPs. Amongst these methods, the incorporation of D-amino acids (D-AA) is an approach that has demonstrated consistent success in improving HDPs. AlthoughPublication Open Access Determination of 2010 Reimbursed Drug Price and Its Budget Impact in Public Hospitals in Thailand(2012) Petcharat Pongcharoensuk; Angkana Saengnapakas; Oraluck Pattanaprateep; เพชรรัตน์ พงษ์เจริญสุข; Mahidol University. Faculty of Pharmacy; Mahidol University. Faculty of Medicine Ramathibodi Hospitalto determine the RP of five high expenditure drug groups and estimate the budget impact of RP implementation. Prescription records of 29 public hospitals in 2010 were collected. Drug utilization and several RP’s of each drug product were determined.... Then, overall budget impact was determined for RP under three different scenarios. Results showed that there were 1.7 million prescriptions, accounted for 2.5 billion baht. By drug group, total number of prescriptions were 39.96%, 26.25%, 16.57%, 13.68% and 3Publication Open Access A case report of intravenous posaconazole in hepatic and renal impairment patient with invasive Aspergillus terreus infection: safety and role of therapeutic drug monitoring(2017) Pitchaya Dilokpattanamongkol; Panadda Panusitthikorn; Rasda Boonprasert; Methee Chayakulkeeree; Porpon Rotjanapan; Mahidol University. Faculty of Pharmacy. Department of Pharmacy; Mahidol University. Faculty of Medicine, Siriraj Hospital. Department of Pharmacy; Mahidol University. Faculty of Medicine, Siriraj Hospital. Clinical Toxicology Laboratory, Siriraj Poison Control Center; Mahidol University. Faculty of Medicine, Siriraj Hospital. Division of Infectious Diseases and Tropical Medicine.; Mahidol University. Department of Medicine, Ramathibodi Hospital. Division of Infectious Diseasesinfection. To our knowledge, this is the first report of intravenous posaconazole use in IA due to A. terreus with hepatic and renal impairment focusing on drug safety and role of therapeutic drug monitoring (TDM). Case presentation: A 37-year-old... of potential adverse effects whilst on intravenous voriconazole, intravenous posaconazole 300 mg every 48 h was chosen with confirmed therapeutic plasma concentrations. Despite the death of the patient and IA deemed uncontrollable, there were no significantPublication Open Access Novel adiponectin variants identified in type 2 diabetic patients reveal multimerization and secretion defects(2011) Prapaporn Jungtrakoon; Nattachet Plengvidhya; Watip Tangjittipokin; Sarin Chimnaronk; Wanisa Salaemae; Nalinee Chongjaroen; Kanjana Chanprasert; Jatuporn Sujjitjoon; Chatchawan Srisawat; Pa-thai Yenchitsomanus; Mahidol University. Faculty of Medical Technology. Department of Clinical Microscopy; Mahidol University. Faculty of Medicine Siriraj Hospital. Department of Medicine; Mahidol University. Institute of Molecular Biosciences.genes causing T2D in Thai patients, we identified 10 novel ADIPOQ variations, several of which were non-synonymous variations observed only in the patients. To examine the impact of these non-synonymous variations on adiponectin structure and biochemical... acid substitution on adiponectin oligomerization. This is also the first report that demonstrates a dominant negative effect of the R131H variant on protein secretion and the possibility of using protein degradation inhibitors as therapeutic agentsPublication Open Access Betamethasone and methylprednisolone usage in lower third molar surgery : Review literature.(2015-09) Sirichai Kiattavornchareon; ศิริชัย เกียรติถาวรเจริญ; Gozali, Peiter; Wu, Michiko; Natthamet Wongsirichat; ณัฐเมศร์ วงศ์สิริฉัตร; Suphachai Suphangul; ศุภชัย สุพรรณกุล; Natthamet Wongsirichat; ณัฐเมศร์ วงศ์สิริฉัตร; Mahidol University. Faculty of Dentistry. Department of Oral and Maxillofacial Surgery; Mahidol University. Faculty of Dentistry. Advance General dentistry DepartmentThe surgical extraction of lower third molar is the most frequent intervention in oral surgery. This procedure is often associated with significant postoperative sequalae that may have both a biological and social impact. Beside severe complicationsPublication Open Access Prediction of difficulty in impacted lower third molars extraction; review literature.(2015-09) Latt, Maung Maung; Pruedy Chewpreecha; พฤทธิ์ ชิวปรีชา; Natthamet Wongsirichat; ณัฐเมศร์ วงศ์สิริฉัตร; Natthamet Wongsirichat; ณัฐเมศร์ วงศ์สิริฉัตร; Mahidol University. Faculty of Dentistry. Department of Oral and Maxillofacial SurgerySurgical removal of impacted mandibular third molars can present with certain post-operative complications such as pain, swelling and trismus although the removal of these teeth is common minor surgical procedure. This review is intended to know... the different aspects of the lower third molars impaction classifications and degree of difficulties in related articles. On the evaluation of radiographic images, we found that surgical difficulties in extracting impacted mandibular third molars can be expectedPublication Open Access World Antimalarial Resistance Network (WARN) IV: clinical pharmacology(2007-09-06) Barnes, Karen I.; Lindegardh, Niklas; Ogundahunsi, Olumide; Olliaro, Piero; Plowe, Christopher V.; Randrianarivelojosia, Milijaona; Gbotosho, Grace O; Watkins, William M.; Sibley, Carol H.; White, Nicholas J.; Barnes, Karen I.; Mahidol University. Faculty of Tropical Medicine. Mahidol Oxford Tropical Medicine Research Unit (MORU).blood concentration data to the therapeutic response (pharmacodynamics). By pooling all available pharmacokinetic data, while paying careful attention to the analytical methodologies used, the limitations of small (and thus underpowered) individual... should contribute to improving the quantity, relevance and quality of these studies. A better understanding of the pharmacokinetic properties of antimalarials and a more clear definition of what constitutes "therapeutic drug levels" would allow morePublication Open Access A single-tube allele specific-polymerase chain reaction to detect T315I resistant mutation in chronic myeloid leukemia patients(2011) Wanwisa Wongboonma; Wanna Thongnoppakhun; Chirayu U Auewarakul; Mahidol University. Faculty of Medicine Siriraj Hospital. Department of MedicineKD mutations, has been shown to be strongly associated with TKI resistance and subsequent therapeutic failure. A simple and sensitive method is thus required to detect T315I mutation at the earliest stage. Methods: A single-tube allele specificPublication Open Access Naïve-pooled pharmacokinetic analysis of pyrazinamide, isoniazid and rifampicin in plasma and cerebrospinal fluid of Vietnamese children with tuberculous meningitis(2016) Pouplin, Thomas; Nguyen Duc Bang; Pham Van Toi; Pham Nguyen Phuong; Nguyen Huy Dung; Tran Ngoc Duong; Caws, Maxine; Thwaites, Guy E.; Tarning, Joel; Day, Jeremy N.; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research UnitBackground: Among the various forms of TB, tuberculous meningitis (TBM) is the most severe, with about 30 % mortality and 50 % of survivors left with neurological sequelae. Children suffer more frequently from TBM than adults and outcomes are often poor due to difficulties in making the diagnosis and uncertainty regarding the best anti-tuberculosis drug regimen. The aim of this prospective study was to describe the pharmacokinetics of pyrazinamide, isoniazid and rifampicin in plasma and cerebrospinal fluid of children with tuberculous meningitis treated with the standard TBM regimen. Methods: We performed a prospective observational study of 100 consecutively treated children (≤15 years of age) with tuberculous meningitis in Ho Chi Minh City, Vietnam. Children were treated according to the 2006 WHO recommended pediatric treatment regimen consisting of isoniazid (5 mg/kg), rifampicin (10 mg/kg) and ethambutol (15 mg/kg) for 8 months, with the addition of pyrazinamide (25 mg/kg) for the first 3 months and streptomycin (15 mg/kg) for the first 2 months. Pyrazinamide, isoniazid and rifampicin concentrations were measured in plasma at day 14 and in cerebrospinal fluid (CSF) at 1 month by HPLC-UV. A naïve-pooled noncompartmental data analysis was used to describe the pharmacokinetic properties of drugs in the two-age groups of children ≤ 4 years or > 4 years of age. Results: Younger children, when compared to older children, presented a higher body weight-normalized clearance and volume of distribution, and lower median total plasma exposures for the three studied drugs with −14 %, −22 % and −16 % for Pyrazinamide, Isoniazid and Rifampicin, respectively. In CSF, individual concentrations of isoniazid and pyrazinamide were comparable to that in plasma in both age groups; but rifampicin concentrations were lower than the minimum inhibitory concentration of susceptible bacteria in all but two children. Conclusions: There is an age-dependent variation in the plasma and cerebrospinal fluid pharmacokinetics of rifampicin, isoniazid and pyrazinamide. The safety and efficacy of higher doses of rifampicin should be investigated for the treatment of childhood tuberculous meningitis.