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Publication Metadata only In vivo and in vitro hemostatic activity of Chromolaena odorata leaf extract(2012-09-01) Hataichanok Pandith; Suchitra Thongpraditchote; Yuvadee Wongkrajang; Wandee Gritsanapan; Mahidol University. The hemostatic mechanisms were tested using in vitro platelet aggregation and blood coagulation tests in sheep plasma. Results: All extracts displayed significantly reducing bleeding time ( < 2.5min) in rats but did not induce platelet aggregation or blood... coagulation and platelet aggregation in in vitro tests should be further studied. © 2012 Informa Healthcare USA, Inc.Item Metadata only Exploring novel indomethacin-derived compounds via investigation of NSAIDs through molecular docking and in vitro testing for anti-amyloid beta aggregation(2024-01-01) Laivut S.; Jarusintanakorn S.; Sripha K.; Laivut S.; Mahidol UniversityBEG) and AP25-35 (1QWP), which are crucial binding sites on the Aβ peptide. In vitro experiments evaluated the ability of six NSAIDs to inhibit Aβ aggregation through ThT flavin assays. Indomethacin emerged as the prototype molecule for developing aPublication Metadata only In vitro-in vivo correlation study for the dermatopharmacokinetics of terbinafine hydrochloride topical cream(2013-09-01) Suwadee Saeheng; Wichit Nosoongnoen; Supenya Varothai; Korbtham Sathirakul; Mahidol University; Walailak University%. Conclusions: In vitro tape stripping using the separated pig ear skin as a viable membrane of the franz diffusion cell testing demonstrates the potential to represent in vivo tape stripping in human for topical bioavailability/bioequivalence study...Background: To investigate the relationship between dermatopharmacokinetic (DPK) tape stripping from in vitro and in vivo using 1% terbinafine hydrochloride topical cream as the model formulation. Methodology: In vitro and in vivo tape strippingsPublication Metadata only In-vitro activity of carbapenem antibiotics against β-lactam susceptible and resistant strains of Burkholderia pseudomallei(1996-04-29) M. D. Smith; V. Wuthiekanun; A. L. Walsh; N. J. White; Mahidol University; Nuffield Department of Clinical MedicineFour carbapenem antibiotics were tested for their in-vitro activities (MICs, MBCs and time-kill studies) against Burkholderia pseudomallei. The carbapenems were all more active than either ceftazidime or co-amoxiclav against strains of B.... pseudomallei with a normal susceptibility pattern. Biapenem was the most active antibiotic tested. All four carbapenems retained bactericidal activity against 24 strains of B. pseudomallei with reduced susceptibility to ceftazidime and/or co-amoxiclav.Publication Metadata only Mucoadhesive properties of various pectins on gastrointestinal mucosa: An in vitro evaluation using texture analyzer(2007-08-01) Nartaya Thirawong; Jurairat Nunthanid; Satit Puttipipatkhachorn; Pornsak Sriamornsak; Silpakorn University; Mahidol Universityequipped with mucoadhesive platform. The instrumental parameters and test conditions such as pre-hydration time of pectin disc, contact time, contact force, test speed of probe withdrawal, GI tissue and test medium were also studied. Two parameters derived... properties. The mucoadhesion of pectin increased with the increased contact time and contact force, but not by the increased probe withdrawal speed. Tissue from different parts of GI tract and test medium also influenced the mucoadhesion. Pectins showed aPublication Metadata only Mechanism-Based Design, Synthesis, and in Vitro Antimalarial Testing of New 4-Methylated Trioxanes Structurally Related to Artemisinin: The Importance of a Carbon-Centered Radical for Antimalarial Activity(1994-04-01) Gary H. Posner; Chang Ho Oh; Dasong Wang; Lucia Gerena; Wilbur K. Milhous; Steven R. Meshnick; Wanida Asawamahasadka; Johns Hopkins University; Walter Reed Army Institute of Research; University of Michigan School of Public Health; Mahidol UniversityPublication Metadata only The antimicrobial susceptibility of pseudomonas pseudomallei. Emergence of resistance in vitro and during treatment(1989-09-01) D. A.B. Dance; V. Wuthiekanun; W. Chaowagul; N. J. White; Mahidol University; John Radcliffe Hospital; Sappasitthiprasong HospitalWe have measured the in-vitro activity of 27 antimicrobials against 211 clinical and ten reference strains of Pseudomonas pseudomallei. Imipenem was the most active antibiotic tested, followed by piperacillin, doxycycline, amoxycillin/clavulanic... acid, cefixime, cefetamet, aziocillin and ceftazidime, all of which had MICs of ≤ 2 mg/l for the majority of strains. The measured MICs were dependent on the media and inocula used, to an extent which varied with the antibiotic class under test; MICsPublication Metadata only Current investigations into the genotoxicity of zinc oxide and silica nanoparticles in mammalian models in vitro and in vivo: Carcinogenic/genotoxic potential, relevant mechanisms and biomarkers, artifacts, and limitations(2014-12-15) Jee Young Kwon; Preeyaporn Koedrith; Young Rok Seo; Dongguk University, Seoul; Mahidol Universitygenotoxicity; however, NP genotoxic/carcinogenic effects and the underlying mechanisms remain to be elucidated. In this review, we address some metal and metal oxide NPs of interest and current genotoxicity tests in vitro and in vivo. Metal NPs can cause DNA... damage such as chromosomal aberrations, DNA strand breaks, oxidative DNA damage, and mutations. We also discuss several parameters that may affect genotoxic response, including physicochemical properties, widely used assays/end point testsItem Metadata only In Vitro Development of Local Antiviral Formulations with Potent Virucidal Activity Against SARS-CoV-2 and Influenza Viruses(2025-03-01) Ponphaiboon J.; Krongrawa W.; Limmatvapirat S.; Tubtimsri S.; Jittmittraphap A.; Leaungwutiwong P.; Mahidol C.; Ruchirawat S.; Kittakoop P.; Limmatvapirat C.; Ponphaiboon J.; Mahidol University.1–0.2% w/w), and CPC (0.05–0.075% w/w). In vitro virucidal activity assays were conducted to assess the antiviral efficacy of the formulations against SARS-CoV-2 and influenza viruses. Stability testing was also performed under various storage...Background/Object: This study investigates the in vitro antiviral potential of D-limonene (DLM), monolaurin (ML), and cetylpyridinium chloride (CPC) in formulations targeting SARS-CoV-2 and influenza viruses. The aim was to develop oral and nasalPublication Metadata only In vitro susceptibility of Trichomonas vaginalis to AT-specific minor groove binding drugs(2003-08-01) Porntip Chavalitshewinkoon-Petmitr; Muhaimin Ramdja; Somsri Kajorndechakiat; Raymond K. Ralph; William A. Denny; Prapon Wilairat; Mahidol University; University of Auckland; Auckland Cancer Society Research Centrespecificity were tested for their antitrichomonal activities. Minimum inhibitory concentrations (MICs) were determined for these compounds against a local strain of T. vaginalis in culture. Among 14 bisquaternary quinolinium compounds tested, an N-ethyl