936 results
Search Results
Now showing 1 - 10 of 936
Publication Metadata only Consequences of circadian disruption on cardiometabolic health(2015-12-01) Sirimon Reutrakul; Kristen L. Knutson; Mahidol University; University of Chicago© 2015 Elsevier Inc. Cardiovascular disease, diabetes and obesity are highly prevalent diseases associated with reduced quality of life and life expectancy. We discuss a novel risk factor for these cardiometabolic diseases: circadian disruption.... Circadian disruption occurs when the internal circadian (∼24-hour) rhythms are not in synchrony with the environment or each other. This paper reviews (1) cardiometabolic health of shift work, which often leads to circadian disruption, (2) effectsItem Metadata only Causal attribution of improving behavior among children with attention-deficit(Mahidol University. Mahidol University Library and Knowledge Center, 2005) Maadmanee Veeranarong; Veena SirisookItem Metadata only Alpha-tubulin relocalization is involved in calcium oxalate-induced tight junction disruption in renal epithelial cells(2022-12-01) Hadpech S.; Peerapen P.; Thongboonkerd V.; Mahidol UniversityMicrotubule (MT) is associated with tight junction (TJ) structure and function. While calcium oxalate monohydrate (COM) commonly causes TJ disruption, its effects on MT remain unknown. This study thus addressed the involvement of a major MT protein..., α-tubulin, in COM-induced TJ disruption. Protein-protein interactions analysis demonstrated that α-tubulin directly interacted with a TJ protein, zonula occludens-1 (ZO-1). MDCK renal cells were polarized and incubated with COM crystals for 48 hItem Metadata only AI and the psychology of educational disruption: Historical patterns and cognitive implications(2025-10-01) Promsiri T.; Promsiri T.; Mahidol UniversityArtificial intelligence (AI) and, concomitantly, large language models (LLMs), emerge as an unprecedentedly disruptive force in education. We contend that AI is not just a technological disruption but also a psychological inflection point... that reconfigures the evolving contours of cognition, motivation, and agency under technological pressure. Using Disruptive Innovation Theory (DIT), the Technological Pedagogical Content Knowledge (TPACK) framework, and Postdigital Education Theory (PET), AIItem Metadata only Compound D from Zingiber cassumunar Roxb. attenuated type 2 inflammatory cytokine-induced tight junction disruption in airway epithelial cells(2025-06-01) Poachanukoon O.; Termworasin P.; Tharabenjasin P.; Dechatiwongse Na Ayudhya T.; Moonwiriyakit A.; Poachanukoon O.; Mahidol UniversityBACKGROUND: Barrier disruption in the airway mucosae has been implicated in allergic type 2 inflammatory diseases such as allergic rhinitis and asthma. Zingiber cassumunar Roxb. has long been used in traditional medicine to treat allergic diseases...-induced barrier disruption. METHODS: Type 2 cytokine (IL-4 and IL-13)-exposed 16HBE human bronchial epithelial cells were treated with compound D. After 24, 48, and 72 h, cytotoxicity, epithelial integrity, and tight junction (TJ) disruption werePublication Metadata only P38 MAPK mediates calcium oxalate crystal-induced tight junction disruption in distal renal tubular epithelial cells(2013-01-28) Paleerath Peerapen; Visith Thongboonkerd; Mahidol UniversityWe examined whether p38 MAPK plays role in calcium oxalate monohydrate (COM) crystal-induced tight junction disruption. Polarized MDCK cells were pretreated with or without 20 μM SB239063 (p38 MAPK inhibitor) for 2-h, and then incubated with 100 μg... levels of two tight junction proteins, zonula occludens-1 (ZO-1) and occludin. Immunofluorescence study revealed disruption of tight junction, redistribution, and dissociation of ZO-1 and occludin. Moreover, transepithelial resistance (TER) showedPublication Metadata only Topical Application of Honey in Treatment of Abdominal Wound Disruption(1992-01-01) Winit Phuapradit; Nopadol Saropala; Mahidol Universityas if the problem was an infected haematoma which is an unusual cause of wound disruption in the editor's experience; yet the authors encountered 15 cases in 19 months, and quoted no case of the complete wound dehiscence referred to above! Summary: The usefulness... of honey application as an alternative method of managing abdominal wound disruption was assessed. Fifteen patients whose wound disrupted after Caesarean section were treated with honey application and wound approximation by micropore tape insteadPublication Metadata only Calcium oxalate monohydrate crystal disrupts tight junction via F-actin reorganization(2021-08-25) Paleerath Peerapen; Visith Thongboonkerd; Siriraj Hospitalcomposition in kidney stones, has been shown to disrupt tight junction but with an unclear mechanism. This study aimed to address whether COM crystal disrupts tight junction via actin deregulation. MDCK distal renal tubular epithelial cells were treated.... These findings indicate that COM crystal does not reduce the total level of actin but causes tight junction disruption via F-actin reorganization.Item Open Access ปาฐกถาเกียรติยศ ศาสตราจารย์นายแพทย์ชัชวาล โอสถานนท์ ครั้งที่ 11 เรี่อง การปรับตัวของมหาวิทยาลัย เพื่อตอบโจทย์การเปลี่ยนแปลงในยุค Disruption(2563) อุดม คชินทร; มหาวิทยาลัยมหิดล. กองบริหารงานวิจัยItem Metadata only Associations between the stringency of COVID-19 containment policies and health service disruptions in 10 countries(2023-12-01) Reddy T.; Kapoor N.R.; Kubota S.; Doubova S.V.; Asai D.; Mariam D.H.; Ayele W.; Mebratie A.D.; Thermidor R.; Sapag J.C.; Bedregal P.; Passi-Solar Á.; Gordon-Strachan G.; Dulal M.; Gadeka D.D.; Mehata S.; Margozzini P.; Leerapan B.; Rittiphairoj T.; Kaewkamjornchai P.; Nega A.; Awoonor-Williams J.K.; Kruk M.E.; Arsenault C.; Mahidol UniversityBackground: Disruptions in essential health services during the COVID-19 pandemic have been reported in several countries. Yet, patterns in health service disruption according to country responses remain unclear. In this paper, we investigate... associations between the stringency of COVID-19 containment policies and disruptions in 31 health services in 10 low- middle- and high-income countries in 2020. Methods: Using routine health information systems and administrative data from 10 countries (Chile