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Item Metadata only Mapping the immune response to burkholderia mallei during experimental equine glanders infection(2004) Rachaneeporn Tiyawisutsri; รัชนีพร ติยะวิสุทธิ์ศรี; Clarke, Simon; Foster, Simon; Narisara Chantratita; นริศรา จันทราทิตย์; White, Nicholas J; Day, Nicholas PJ; Woods, Don; Peacock, Sharon J; Mahidol University. Faculty of Tropical Medicine. The Wellcome Trust-Mahidol University-Oxford Tropical Medicine Research ProgrammeBurkholoderia mallei is the cause of glanders Human infection is extremely. Rare, but renewed interesting parallels the realization that this organism could be used as an agent of bioterrorism. There is a need to develop an effective vaccine.... This was used to screen sera from two horses with experimental glanders infected with B mallei 23344. More than 140 inserts were sequenced, 30 of which were unique. These included surface expressed and Transmemembrane proteins secreted proteinsPublication Metadata only Melioidosis and Glanders(2012-11-01) Nicholas J. White; Mahidol UniversityPublication Metadata only Burkholderia Hep_Hap autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis(2007-04-11) Rachaneeporn Tiyawisutsri; Matthew T.G. Holden; Sarinna Tumapa; Sirirat Rengpipat; Simon R. Clarke; Simon J. Foster; William C. Nierman; Nicholas P.J. Day; Sharon J. Peacock; Mahidol University; Chulalongkorn University; Wellcome Trust Sanger Institute; University of Sheffield; J. Craig Venter Institute; George Washington University School of Medicine and Health Sciences; Nuffield Department of Clinical MedicineBackground. The bacterial biothreat agents Burkholderia mallei and Burkholderia pseudomallei are the cause of glanders and melioidosis, respectively. Genomic and epidemiological studies have shown that B. mallei is a recently emerged, host... restricted clone of B. pseudomallei. Results. Using bacteriophage-mediated immunoscreening we identified genes expressed in vivo during experimental equine glanders infection. A family of immunodominant antigens were identified that share protein domainItem Metadata only Evaluation of two different vaccine platforms for immunization against melioidosis and glanders(2022-08-17) Biryukov S.S.; Cote C.K.; Klimko C.P.; Dankmeyer J.L.; Rill N.O.; Shoe J.L.; Hunter M.; Shamsuddin Z.; Velez I.; Hedrick Z.M.; Rosario-Acevedo R.; Talyansky Y.; Schmidt L.K.; Orne C.E.; Fetterer D.P.; Burtnick M.N.; Brett P.J.; Welkos S.L.; DeShazer D.; Mahidol Universitymelioidosis and glanders to identify the most efficacious one(s) and define residual requirements for their transition to the non-human primate aerosol model. Studies were conducted in the C57BL/6 mouse model to evaluate the humoral and cell-mediated immunePublication Metadata only Melioidosis patient serum-reactive synthetic tetrasaccharides bearing the predominant epitopes of Burkholderia pseudomallei and Burkholderia mallei O-antigens(2019-01-01) Maude Cloutier; Emmanilo Delar; Kevin Muru; Seynabou Ndong; Robert R. Hoyeck; Taniya Kaewarpai; Narisara Chantratita; Mary N. Burtnick; Paul J. Brett; Charles Gauthier; INRS-Institut Armand Frappier; Mahidol University; University of Nevada School of Medicine© 2019 The Royal Society of Chemistry. Melioidosis and glanders, respectively caused by the Gram-negative bacteria Burkholderia pseudomallei (Bp) and Burkholderia mallei (Bm), are considered as urgent public health issues in developing countries... and potential bioterrorism agents. Bp and Bm lipopolysaccharides (LPS) have been identified as attractive vaccine candidates for the development of prophylactic measures against melioidosis and glanders. Bp and Bm express structurally similar LPSs wherein the OItem Metadata only Melioidosis vaccines: recent advances and future directions(2025-01-01) Sengyee S.; Weiby S.B.; Rok I.T.; Burtnick M.N.; Brett P.J.; Sengyee S.; Mahidol Universityto provide some level of protection against Burkholderia mallei, the etiologic agent of glanders. In this review, we examine the different approaches that have recently been used to develop melioidosis vaccine candidates, highlighting both traditional... and emerging vaccine platform technologies. Using these approaches, several promising melioidosis and glanders candidates have been identified with pre-clinical animal studies providing valuable insights into the immunogenic and protective capacitiesPublication Metadata only Workshop on Treatment of and Postexposure Prophylaxis for Burkholderia pseudomallei and B. mallei Infection, 2010(2012-12-01) Rebecca Lipsitz; Susan Garges; Rosemarie Aurigemma; Prasith Baccam; David D. Blaney; Allen C. Cheng; Bart J. Currie; David Dance; Jay E. Gee; Joseph Larsen; Direk Limmathurotsakul; Meredith G. Morrow; Robert Norton; Elizabeth O'Mara; Sharon J. Peacock; Nicki Pesik; L. Paige Rogers; Herbert P. Schweizer; Ivo Steinmetz; Gladys Tan; Patrick Tan; W. Joost Wiersinga; Vanaporn Wuthiekanun; Theresa L. Smith; United States Department of Health and Human Services; National Institutes of Health, Bethesda; IEM; Centers for Disease Control and Prevention; Royal Darwin Hospital; Menzies School of Health Research; Monash University; Alfred Hospital; Mahosot Hospital; University of Oxford; Mahidol University; Townsville Hospital; University of Cambridge; Colorado State University; Ernst-Moritz-Arndt-Universitat Greifswald; DSO National Laboratories; Genome Institute of; Duke-NUS Graduate Medical School Singapore; Academic Medical Centre, University of Amsterdampseudomallei and B. mallei infections, which cause melioidosis and glanders, respectively. Drugs recommended by consensus of the participants are ceftazidime or meropenem for initial intensive therapy, and trimethoprim/sulfamethoxazole or amoxicillin/clavulanic... acid for eradication therapy. For postexposure prophylaxis, recommended drugs are trimethoprim/sulfamethoxazole or co-amoxiclav. To improve the timely diagnosis of melioidosis and glanders, further development and wide distribution of rapid diagnosticPublication Metadata only Antigenic relatedness between Burkholderia pseudomallei and Burkholderia mallei(2002-01-01) Narisara Anuntagool; Stitaya Sirisinha; Mahidol UniversityBurkholderia pseudomallei and Burkholderia mallei are causative agents of distinct diseases, namely, melioidosis and glanders, respectively. The two species are very closely related, based on DNA-DNA homology, base sequence of the 16S rPublication Metadata only Short report: Evaluation of a latex agglutination assay for the identification of Burkholderia pseudomallei and Burkholderia mallei(2014-01-01) Brea D. Duval; Mindy G. Elrod; Jay E. Gee; Narisara Chantratita; Sarunporn Tandhavanant; Direk Limmathurotsakul; Alex R. Hoffmaster; Centers for Disease Control and Prevention; Mahidol UniversityCases of melioidosis and glanders are rare in the United States, but the etiologic agents of each disease (Burkholderia pseudomallei and Burkholderia mallei, respectively) are classified as Tier 1 select agents because of concerns aboutPublication Metadata only PCR-RFLP based differentiation of Burkholderia mallei and Burkholderia pseudomallei(2004-04-01) Suda Tanpiboonsak; Atchara Paemanee; Sasinee Bunyarataphan; Sumalee Tungpradabkul; Mahidol UniversityBurkholderia mallei and Burkholderia pseudomallei manifest a high similarity with regard to clinical syndromes, glanders and melioidosis. Phenotypic and genotypic characters are also highly similar. In an attempt to differentiate the two organisms