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Item Metadata only Speciation and structural characterization of meso-HMPAO metal complexes(Mahidol University. Mahidol University Library and Knowledge Center, 2002) Chomchai Suksai; Waret Veerasai; Prapin WilairatPublication Metadata only Synthesis, antioxidant and antimicrobial activities of metal complexes of 2-thiouracil-hydroxyquinoline derivatives(2018-01-01) Apilak Worachartcheewan; Ratchanok Pingaew; Decha Lekcharoen; Supaluk Prachayasittikul; Somsak Ruchirawat; Virapong Prachayasittikul; Chulabhorn Research Institute; Thailand Ministry of Education; Mahidol University; Srinakharinwirot Universitycontaining metal ions coordination are designed for SOD mimic and other biological activities. Objective: This study aimed to synthesize metal (Ni, Cu, Mn) complexes of mixed ligands of 2-thiouracil (2TU) with 8-hydroxyquinoline (8HQ) (1-3) and with 2...-hydroxyquinoline (2HQ) (4-6), and to determine antioxidant and antimicrobial activities. Results: The metal complexes 1-6 elicited SOD activity with IC 50 of 1.20-500.26 µM, particularly, complex 5 (2TU-Cu-2HQ) showed the highest SOD activity with IC 50 of 1.20 µPublication Metadata only Conformational analysis of alkali metal complexes of anionic species of aspartic acid, their interconversion and deprotonation: A DFT investigation(2008-02-01) Wichien Sang-Aroon; Vithaya Ruangpornvisuti; Mahidol UniversityGas-phase geometry-optimized structures of aspartate complexes of anionic species (Hasp-) with lithium, sodium and potassium metal cations and transition-state structures for their interconversions were obtained using the density functional theory... computations at the B3LYP/6-311++G(d,p) level of theory. The metal ion affinities of Hasp-species and deprotonation energies of [Hasp-M] complexes, M = Li+, Na+and K+, and their conformers were obtained. Relative energies of the [Hasp-M] complex conformersPublication Open Access Investigation of aromatase inhibitory activity of metal complexes of 8-hydroxyquinoline and uracil derivatives(2014-08-14) Veda Prachayasittikul; Ratchanok Pingaew; Virapong Prachayasittikul; Chanin Nantasenamat; Somsak Ruchirawat; Supaluk Prachayasittikul; Mahidol University. Faculty of Medical Technology. Department of Clinical Microbiology and Applied Technology; Mahidol University. Faculty of Medical Technology. Center of Data Mining and Biomedical Informaticsfor controlling estrogen levels to improve prognosis of estrogen-related cancers and diseases. Herein, a series of metal (Mn, Cu, and Ni) complexes of 8-hydroxyquinoline (8HQ) and uracil derivatives (4–9) were investigated for their aromatase inhibitory...) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results: Only Cu complexes (6 and 9) exhibited aromatase inhibitory effect with IC50 0.30 and 1.7 µM, respectively. Cytotoxicity test against MRC-5 cells showed that MnPublication Metadata only Conformational analysis of alkali metal complexes of aspartate dianion and their interactions in gas phase(2007-07-01) Wichien Sang-aroon; Vithaya Ruangpornvisuti; Mahidol University. The metal ion affinities (MIAs) of asp2-species and its complexes [asp-M]-, M = Li+, Na+and K+were determined using the vibrational frequency calculations at the same level of theory. The most stable complex conformer for aspartate complexes with Li+, Na...+and K+alkali cations were found as a tri-coordinated form. All complexations of [asp-M]-and [asp-M2] complexes were found to be exothermic reactions. Relative bond distances between the alkali metal cation M+and the binding atoms of aspartate ion in [aspPublication Open Access Antimalarial and Antimicrobial Activities of 8-Aminoquinoline-Uracils Metal Complexes(2015-12) Kamonrat Phopin; Nujarin Sinthupoom; Lertyot Treeratanapiboon; Sarun Kunwittaya; Supaluk Prachayasittikul; Somsak Ruchirawat; Virapong Prachayasittikul; Mahidol University. Faculty of Medical Technology. Department of Clinical Microbiology and Applied Technology8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6...) as antimalarial and antimicrobial agents. Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities. Moreover, Cu complexes 2 (8AQ-Cu-5Iu) and 5 (8AQ-Cu-5Nu) exerted antimicrobial activities against Gram-negative bacteria including PPublication Metadata only Antimalarial and antimicrobial activities of 8-aminoquinoline-uracils metal complexes(2016-02-18) Kamonrat Phopin; Nujarin Sinthupoom; Lertyot Treeratanapiboon; Sarun Kunwittaya; Supaluk Prachayasittikul; Somsak Ruchirawat; Virapong Prachayasittikul; Mahidol University; Chulabhorn Research Institute; Ministry of Educationof 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and antimicrobial agents. Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities. Moreover, Cu complexes 2 (8AQ-Cu-5Iu) and 5... (8AQ-Cu-5Nu) exerted antimicrobial activities against Gram-negative bacteria including P. shigelloides and S. dysenteriae. The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novelPublication Metadata only Highly efficient metal(iii) porphyrin and salen complexes for the polymerization of: Rac -lactide under ambient conditions(2019-01-01) Siriwan Praban; Parichat Piromjitpong; Vagulejan Balasanthiran; Savithra Jayaraj; Malcolm H. Chisholm; Jonggol Tantirungrotechai; Khamphee Phomphrai; Vidyasirimedhi Institute of Science and Technology; Mahidol University; Ohio State University; Monomer-Polymer and Dajac Labs© 2019 The Royal Society of Chemistry. Ligated metal(iii) complexes, Al(iii), In(iii), Cr(iii), and Co(iii), containing tetraphenylporphyrin (TPP) and cyclohexylsalen (Cy-salen) ligands were investigated for the polymerization of rac-lactide (rac...-LA). A combination of metal complexes, co-catalyst, and co-initiator was shown to be highly efficient for the ring-opening polymerization of rac-LA at room temperature. Influences of metal centers, ligands, and co-catalysts were investigated. HigherPublication Metadata only Transition metal complexes of 8-aminoquinoline-5-substituted uracils with antioxidative and cytotoxic activities(2013-11-01) Ratchanok Pingaew; Apilak Worachartcheewan; Veda Prachayasittikul; Supaluk Prachayasittikul; Somsak Ruchirawat; Virapong Prachayasittikul; Srinakharinwirot University; Mahidol University; Chulabhorn Research InstituteMetal complexes of 8-aminoquinoline (8AQ) derivatives were reported. This study presents a series of synthesized transition metal complexes of mixed ligands 8AQ-5-iodouracils (1-3) and 8AQ-5-nitrouracil (4-6) which have been investigated... for their antioxidative and cytotoxic activities, as well as, powder X-ray diffraction patterns. Ni complex of 8AQ-5-nitrouracil (6) exerted significant cytotoxicity against MOLT-3 cell and superoxide scavenging activity. The results demonstrate an application of 8AQPublication Metadata only Antimicrobial activity of 8-hydroxyquinoline and transition metal complexes(2013-06-17) S. Srisung; T. Suksrichavalit; S. Prachayasittikul; S. Ruchirawat; V. Prachayasittikul; Srinakharinwirot University; Mahidol University; Chulabhorn Research InstituteHeterocyclic compounds like 8-hydroxyquinoline (8HQ) and derivatives have been found in natural products and therapeutics. Herein 8HQ and metal complexes of 8HQ-5-substituted (X) uracils, X = I, N02(1-6) were investigated for their antimicrobial... fungus, Candida albicans. The findings reveal 8HQ as the very potent antimicrobial agent and a series of 8HQ transition metal complexes as novel antimicrobials as well as the applications of 8HQ for the design and synthesis of new and potential