Publication: Transition metal complexes of 8-aminoquinoline-5-substituted uracils with antioxidative and cytotoxic activities
Issued Date
2013-11-01
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ISSN
1875628X
15701808
15701808
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2-s2.0-84887864374
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Mahidol University
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SCOPUS
Bibliographic Citation
Letters in Drug Design and Discovery. Vol.10, No.9 (2013), 859-864
Suggested Citation
Ratchanok Pingaew, Apilak Worachartcheewan, Veda Prachayasittikul, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul Transition metal complexes of 8-aminoquinoline-5-substituted uracils with antioxidative and cytotoxic activities. Letters in Drug Design and Discovery. Vol.10, No.9 (2013), 859-864. doi:10.2174/15701808113109990004 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/31175
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Title
Transition metal complexes of 8-aminoquinoline-5-substituted uracils with antioxidative and cytotoxic activities
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Abstract
Metal complexes of 8-aminoquinoline (8AQ) derivatives were reported. This study presents a series of synthesized transition metal complexes of mixed ligands 8AQ-5-iodouracils (1-3) and 8AQ-5-nitrouracil (4-6) which have been investigated for their antioxidative and cytotoxic activities, as well as, powder X-ray diffraction patterns. Ni complex of 8AQ-5-nitrouracil (6) exerted significant cytotoxicity against MOLT-3 cell and superoxide scavenging activity. The results demonstrate an application of 8AQ molecule as a potential ligand for new bioactive compounds. ©2013 Bentham Science Publishers.