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Item Metadata only Genetic changes resulting in breast and ovarian cancers in BRCA 1/2 negative families in Thailand(Mahidol University. Mahidol University Library and Knowledge Center, 2023) Malinee Pongsavee; Pimpicha PatmasiriwatPublication Metadata only The accuracy of intraoperative frozen sections in epithelial ovarian tumor(2021-02-01) Korrakot Soitong; Tharintorn Chansoon; Chompunoot Kongsawatvorakul; Ramathibodi Hospital), negative predictive values (NPV) were studied. Results: One hundred sixteen ovarian specimen reports were reviewed, comprised of 74 (63.8%) benign, 21 (18.1%) borderline, and 21 (18.1%) malignant neoplasms. Nine cases (7.7%) were discordant diagnoses....7%, 80.9%, and 100%, and 100%, 95.8%, and 95.0%, respectively. Conclusion: The intraoperative frozen section has high accuracy in the diagnosis of ovarian epithelial neoplasm. The results can be used in guidance on the extent and type of surgicalItem Metadata only Cost effectiveness of bevacizumab plus carboplatin paclitaxel versus carboplatin paclitaxel as front line for advanced ovarian cancer in Thailand(2025-12-01) Katanyoo K.; Chaikledkaew U.; Chandeying N.; Katanyoo K.; Mahidol UniversityBevacizumab (BEV) combined with standard chemotherapy with carboplatin and paclitaxel (CP) as the front-line treatment for newly diagnosed advanced-stage epithelial ovarian cancer (EOC) is a promising treatment option. In Thailand, combined BEV... combined BEV and CP according to the Gynecologic Oncology Group-218 (GOG-218) and the Gynecologic Cancer Intergroup International Collaboration on Ovarian Neoplasms 7 (ICON-7) regimens in patients with EOC. The decision tree model and Markov model werePublication Metadata only Malignant ascites in female patients : A seven-year review(1999-01-01) Sarikapan Wilailak; Vasant Linasmita; Songsri Srivannaboon; Mahidol Universitycarried out a retrospective study of 118 cases of malignant ascites diagnosed from January 1986 to December 1992 in female patients. Of the 118 cases, the primary site of the neoplasms was gynecologic in 65 cases (cervix 4, endometrium 6, ovary 52... supportive and symptomatic, surgery and chemotherapy. Survival was longer in gynecologic than in the non-gynecologic and the unknown primary groups. The most common primary site of malignant ascites in females was ovarian cancer. In malignant ascitesPublication Metadata only Does magnetic resonance imaging give value-added than bone scintigraphy in the detection of vertebral metastasis?(2009-06-01) Pipat Chiewvit; Nasuda Danchaivijitr; Kaewta Sirivitmaitrie; Sunanta Chiewvit; Kullatorn Thephamongkhol; Mahidol Universityage 61 years and range 8-84 years). Primary neoplasms include breast cancer (n = 11), colorectal cancer (n = 7), lung cancer (n = 6), prostate cancer (n = 5), nasopharyngeal cancer (n = 5), head and neck cancer (n = 3), thyroid cancer (n = 2), liver... cancer (n = 2), esophagus cancer (n = 1), bladder cancer (n = 1), retroperitoneum cancer (n = 1), medulloblastoma (n = 1), cervical cancer (n = 1), ovarian cancer (n = 1), malignant melanoma (n = 1). The result of bone scintigraphy and MR imaging is usedPublication Open Access Calcific panniculitis and nasopharyngeal cancer-associated adult-onset dermatomyositis: a case report and literature review(2015) Manasmon Chairatchaneeboon; Kanokvalai Kulthanan; Araya Manapajon; Mahidol University. Faculty of Medicine Siriraj Hospital. Department of DermatologyPanniculitis is an uncommon cutaneous manifestation in dermatomyositis. It not only occurs in idiopathic dermatomyositis, but also rarely occurs in the setting of malignancy-associated dermatomyositis. Calcinosis cutis is also less likely to be found in adult-onset dermatomyositis. In malignancy-associated dermatomyositis, panniculitis can precede, concur, or follow the diagnosis of malignancy. We report the case of a 26-year-old Thai female with calcific panniculitis in the setting of adult-onset dermatomyositis associated with nasopharyngeal cancer. The clinical course of calcific panniculitis in our case was not parallel to the course of malignancy. Calcific panniculitis can appear many years after, despite the remission of the cancer. A thorough review of the previously reported literature is also provided.Publication Open Access The effectiveness of cucurbitacin B in BRCA1 defective breast cancer cells(Mahidol University, 2013-02) Moltira Promkan; Sumana Dakeng; Subhas Chakrabarty; Oliver Bögler; Pimpicha Patmasiriwat; Mahidol University. Faculty of Medical TechnologyCucurbitacin B (CuB) is one of the potential agents for long term anticancer chemoprevention. Cumulative evidences has shown that cucurbitacin B provides potent cellular biological activities such as hepatoprotective, anti-inflammatory and antimicrobial effects, but the precise mechanism of this agent is not clearly understood. We examine the biological effects on cancer cells of cucurbitacin B extracted from a Thai herb, Trichosanthes cucumerina L. The wild type (wt) BRCA1, mutant BRCA1, BRCA1 knocked-down and BRCA1 overexpressed breast cancer cells were treated with the cucurbitacin B and determined for the inhibitory effects on the cell proliferation, migration, invasion, anchorage-independent growth. The gene expressions in the treated cells were analyzed for p21/Waf1, p27Kip1 and survivin. Our previous study revealed that loss of BRCA1 expression leads to an increase in survivin expression, which is responsible for a reduction in sensitivity to paclitaxel. In this work, we showed that cucurbitacin B obviously inhibited knocked-down and mutant BRCA1 breast cancer cells rather than the wild type BRCA1 breast cancer cells in regards to the cellular proliferation, migration, invasion and anchorage-independent growth. Furthermore, forcing the cells to overexpress wild type BRCA1 significantly reduced effectiveness of cucurbitacin B on growth inhibition of the endogenous mutant BRCA1 cells. Interestingly, cucurbitacin B promotes the expression of p21/Waf1 and p27Kip1 but inhibit the expression of survivin. We suggest that survivin could be an important target of cucurbitacin B in BRCA1 defective breast cancer cells.Publication Open Access High Incidence of Hepatitis B Infection-Associated Cirrhosis and Hepatocellular Carcinoma in the Southeast Asian Patients with Portal Vein Thrombosis(2011) Korn Lertpipopmetha; Chirayu U Auewarakul; Mahidol University. Faculty of Medicine Siriraj Hospital. Department of Medicine- Trénaunay vascular malformation syndrome were also identified. Other thrombophilic conditions such as myeloproliferative neoplasms, paroxysmal nocturnal hemoglobinuria, protein S deficiency, and anti-phospholipid syndrome were rarely encounteredPublication Open Access Hysteroscopy in Endometrial Cancer(2018) Navamol Lekskul; นวมลล์ เล็กสกุล; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Department of Obstetrics and GynecologyEndometrial cancer is one of the most common gynecological malignancies. The majority of the patients present with abnormal vaginal bleeding; hence, the disease is diagnosed in the early stages. Usually transvaginal ultrasound and endometrial biopsy are the beneficial investigations, notably with occasional failure to obtain adequate endometrial tissue. Hysteroscopy increases the sensitivity and accuracy to identify endometrial cancer; however, the pressure of fluid distension media should be optimized because of the concern of impaired prognosis from malignant cell spillage. In sentinel lymph node mapping, hysteroscopic injection is considered as a method to potentially increase the detection rate in the para-aortic area. Fertility-sparing treatment of endometrial cancer in early stages is feasible with the combination of hysteroscopic resection and progestin therapy.Publication Open Access LINE-1 and Alu hypomethylation in mucoepidermoid carcinoma(2013) Porntipa Sirivanichsuntorn; Somboon Keelawat; Kittipong Danuthai; Apiwat Mutirangura; Keskanya Subbalekha; Nakarin Kitkumthorn; Mahidol University. Faculty of Dentistry. Department of Oral and Maxillofacial PathologyBackground: Mucoepidermoid carcinoma (MEC) can be classified into low-, intermediate-, and high-grade tumors based on its histological features. MEC is mainly composed of three cell types (squamous or epidermoid, mucous and intermediate cells), which correlates with the histological grade and reflects its clinical behavior. Most cancers exhibit reduced methylation of repetitive sequences such as Long INterspersed Element-1 (LINE-1) and Alu elements. However, to date very little information is available on the LINE-1 and Alu methylation status in MEC. The aim of this study was to investigate LINE-1 and Alu element methylation in MEC and compare if key differences in the methylation status exist between the three different cell types, and adjacent normal salivary gland cells, to see if this may reflect the histological grade. Methods: LINE-1 and Alu element methylation of 24 MEC, and 14 normal salivary gland tissues were compared using Combine Bisulfite Restriction Analysis (COBRA). Furthermore, the three different cell types from MEC samples were isolated for enrichment by laser capture microdissection (LCM), essentially to see if COBRA was likely to increase the predictive value of LINE-1 and Alu element methylation. Results: LINE-1 and Alu element methylation levels were significantly different (p<0.001) between the cell types, and showed a stepwise decrease from the adjacent normal salivary gland to the intermediate, mucous and squamous cells. The reduced methylation levels of LINE-1 were correlated with a poorer histological grade. In addition, MEC tissue showed a significantly lower level of LINE-1 and Alu element methylation overall compared to normal salivary gland tissue (p<0.001). Conclusions: Our findings suggest that LINE-1 methylation differed among histological grade mucoepidermoid carcinoma. Hence, this epigenetic event may hold value for MEC diagnosis and prognostic prediction.