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Item Metadata only Associations of angiotensin-converting enzyme and angiotensin II type 1 receptor gene polymorphisms on development of coronary artery disease in type 2 diabetic patients(Mahidol University. Mahidol University Library and Knowledge Center, 2008) Kanchana IntarajornItem Metadata only Gαq protein-biased ligand of angiotensin II type 1 receptor mediates myofibroblast differentiation through TGF-β1/ERK axis in human cardiac fibroblasts(2023-07-15) Parichatikanond W.; Duangrat R.; Mangmool S.; Mahidol Universityunderlying myofibroblast differentiation in human cardiac fibroblasts have not been fully elucidated. Our results demonstrated that antagonism of angiotensin II type 1 receptor (AT1 receptor) and blockade of Gαq protein suppressed angiotensin II (Ang II...Angiotensin II receptors are members of G protein-coupled receptor superfamily that manifest biased signals toward G protein- and β-arrestin-dependent pathways. However, the role of angiotensin II receptor-biased ligands and the mechanismsItem Metadata only The correlation of angiotensin-converting enzyme and angiotensin II receptor type 1 polymorphisms in primary hypercholesterolemia and coronary heart disease(Mahidol University. Mahidol University Library and Knowledge Center, 2007) Decha Silsorn; Atip LikidlilidPublication Metadata only Bivalent angiotensin II suppresses oxidative stress-induced hyper-responsiveness of angiotensin II receptor type i(2013-04-15) Titiwat Sungkaworn; Chutima Jiarpinitnun; Pongkorn Chaiyakunvat; Varanuj Chatsudthipong; Mahidol UniversityAngiotensin II receptor type I (AT1R) is a G-protein coupled receptor involved in regulation of body water-electrolyte balance and blood pressure. Oxidative stress promotes AT1R oligomerization and hyper-responsiveness to its cognate ligand Ang II...) provides another strategy in the development of novel drugs specifically designed for attenuating aberrant responsiveness of cognate receptor (AT1R) under pathological (oxidative stress) conditions. © 2013 Elsevier Masson SAS. All rights reserved.Publication Metadata only Oxidative stress increases angiotensin receptor type i responsiveness by increasing receptor degree of aggregation using image correlation spectroscopy(2011-10-01) Titiwat Sungkaworn; Yongwimon Lenbury; Varanuj Chatsudthipong; Mahidol UniversityOxidative stress and hyper-functioning of angiotensin II receptor type I (AT 1 R) are commonly observed in hypertensive patients but the relationship between oxidative stress and AT 1 R function is still unclear. We investigated the effects of H 2 O...-800 μM), [Ca 2+ ] i was significantly increased upon angiotensin II stimulation. Similarly ICS revealed a significant increase in degree of AT 1 R aggregation in H 2 O 2 treated group during Ang II activation but no difference in cluster densityPublication Metadata only Successful Treatment of Anti–angiotensin II Type 1 Receptor Antibody–Associated Rejection in Kidney Transplantation: A Case Report(2018-04-01) P. Wiwattanathum; A. Ingsathit; D. Thammanichanond; S. Worawichawong; Faculty of Medicine, Ramathibodi Hospital, Mahidol University© 2017 Elsevier Inc. Angiotensin II type 1 receptor (AT1R) antibody, a non-HLA antibody, has been found to have a detrimental effect on kidney allografts. Similarly to HLA antibodies, recipients who have AT1R antibodies are at risk for allograft... to remove these pathologic antibodies similarly to the treatment of HLA antibody–associated rejection, have been unsatisfactory. Some studies recommend using angiotensin receptor blocker to attenuate the adverse effects of AT1R antibody on kidney allograftPublication Metadata only Epac is required for exogenous and endogenous stimulation of adenosine A2B receptor for inhibition of angiotensin II-induced collagen synthesis and myofibroblast differentiation(2018-06-01) Sarawuth Phosri; Kwanchai Bunrukchai; Warisara Parichatikanond; Vilasinee H. Sato; Supachoke Mangmool; Mahidol University© 2018, Springer Science+Business Media B.V., part of Springer Nature. Angiotensin II (Ang II) plays an important role on the pathogenesis of cardiac fibrosis. Prolong and overstimulation of angiotensin II type 1 receptor with Ang II-induced... collagen synthesis and myofibroblast differentiation in cardiac fibroblasts, leading to cardiac fibrosis. Although adenosine and its analogues are known to have cardioprotective effects, the mechanistic by which adenosine A2 receptors (A2Rs) inhibit Ang IIItem Metadata only Dual Blockade of TGF-β Receptor and Endothelin Receptor Synergistically Inhibits Angiotensin II-Induced Myofibroblast Differentiation: Role of AT1R/Gαq-Mediated TGF-β1 and ET-1 Signaling(2023-04-01) Duangrat R.; Parichatikanond W.; Mangmool S.; Mahidol UniversityAngiotensin II (Ang II) upregulates transforming growth factor-beta1 (TGF-β1) and endothelin-1 (ET-1) in various types of cells, and all of them act as profibrotic mediators. However, the signal transduction of angiotensin II receptor (ATR... to and activated endothelin receptor type A (ETAR), leading to increases in collagen I and α-SMA synthesis and stress fiber formation. Remarkably, dual blockade of TGF-β receptor and ETR exhibited the restorative effects to reverse the myofibroblast phenotypePublication Metadata only Angiotensin II may mediate apoptosis via AT1-receptors in the rat cardiac conduction system(2004-01-01) Uraporn Vongvatcharanon; Surapong Vongvatcharanon; Nisaudah Radenahmad; Pornpimol Kirirat; Pranom Intasaro; Prasert Sobhon; Terry Parker; Prince of Songkla University; Mahidol University; University of NottinghamApoptosis and angiotensin II (Ang II) have been suggested as possible causes of arrhythmias. In addition, Ang II via Ang II type I (AT1-) receptors, has been demonstrated to induce cardiomyocyte apoptosis. The transgenic m(Ren-2)27 (TG) rat carries... the additional Ren-2 gene, the expression of which results in an increase in cardiac Ang II, thus potentially affecting the cell growth/death equilibrium. In this study we have investigated the effect of Ang II, via AT1-receptors, on mediating apoptosis in aPublication Metadata only The role of the renin-angiotensin system in the development of insulin resistance in skeletal muscle(2013-09-25) Erik J. Henriksen; Mujalin Prasannarong; University of Arizona College of Medicine - Tucson; Mahidol Universityin numerous physiological functions, and RAS overactivity underlies many conditions of cardiovascular dysregulation. In addition, ANG II, by acting on both endothelial and myocellular AT1 receptors, can induce insulin resistance by increasing cellular... action, due at least in part to enhanced Akt-dependent insulin signaling and insulin-dependent glucose transport activity. ANG-(1-7), which is produced from ANG II by the action of ACE2 and acts via Mas receptors, can counterbalance the deleterious