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Publication Open Access Radiation Dosimetry in Non-Hodgkin’s B-Cell Lymphoma Patients Treated with 131I-Rituximab Radioimmunotherapy(2017) Wirote Changmuang; Arpakorn Kositwattanarerk; Kittipong Thongklam; Kanokon Poonak; Putthiporn Charoenphun; Thanete Doungta; วิโรจน์ ช่างม่วง; อาภากร โฆษิตวัฒนฤกษ์; กิตติพงษ์ ทองกล่ำ; กนกอร ภู่นาค; พุทธิพรณ์ เจริญพันธุ์; ธเนศ ดวงตา; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Department of Diagnostic and Therapeutic Radiology; Thailand Institiute of Nuclear Technology (Public Organization). Radioisotope Center.3 ± 19.4 hours. The mean therapeutic dose was 1.16 ± 0.16 GBq. The mean absorbed dose to liver, lungs, ovaries, red marrow, testes and total body was 0.58 ± 0.05, 0.54 ± 0.05, 0.63 ± 0.06, 0.56 ± 0.05, 0.53 ± 0.05 and 0.54 ± 0.06 mGy/MBq, respectively...Objective: The aim of this study was to calculate a therapeutic dose of 131I-Rituximab after a tracer patient-specific dosimetry based on whole body absorbed dose of 0.75 Gy. Methods: Eight patients (mean ± S.D. age, 59.0 ± 11.6 years) were givenItem Metadata only Metabolic response of diacetoxyscirpenol treated mice to vitamin A(Mahidol University. Mahidol University Library and Knowledge Center, 2024) Tadsanee Punjanon; Voranunt Suphiphat; Thirayudh Glinsukon; Tongtavuch Anukarahanontaand bone marrow cell count of control and DAS treated at 5, 10 mg/KgBW IP for 1,6 hr. White blood cell particularly neutrophil and lymphocyte were elevated in DAS 10 mg/kgBW while the spleen weight was reduced. The hematological change after one dose of DAS... decrease in DNA and RNA of thetes. Hemoglobin, hematocrit, white blood cell, red blood cell count, bone marrow cell, reticulocyte were lower than control. Female was more sensitive than male mice. DAS 15 mg/KgBW IP 48 hr did reduce reticulocyte, white bloodItem Metadata only A 46-Year-Old Thai Woman with Secondary Acquired Pure Red Cell Aplasia Due to Treatment with Recombinant Erythropoietin While on Dialysis for End-Stage Renal Disease Who Recovered Following ABO-Incompatible Kidney Transplantation(2022-01-01) Kitpermkiat R.; Mahidol UniversityObjective: Rare disease Background: Pure red cell aplasia (PRCA) is an uncommon cause of anemia in end-stage kidney disease (ESKD). It is attribut-ed to recombinant human erythropoietin (rHuEPO) administration. Although immunosuppression is the main... developed severe anemia. Bone marrow aspiration and biopsy revealed a reduction of erythroid precursors, consistent with PRCA. Because she had no sibling’s blood group matched with her, ABO-incompatible kidney transplantation was an option for treatment. SheItem Metadata only Post-Therapeutic Dosimetry of Metastatic Castration-Resistant Prostate Cancer With 177Lu-PSMA: Experiences From Two University-Based Hospitals in Thailand(2025-01-01) Pattanawong O.; Charoenphun P.; Chamroonrat W.; Thongpraparn T.; Poon-iad N.; Khiewvan B.; Chuamsaamarkkee K.; Pattanawong O.; Mahidol University.79 GBq (range 5.00–7.29 GBq). Normal organ absorbed doses, from lowest to highest, were red marrow (0.03 ± 0.03 Gy/GBq), total body (0.04 ± 0.03 Gy/GBq), liver (0.13 ± 0.33 Gy/GBq), salivary glands (0.65 ± 0.42 Gy/GBq), and kidneys (0.72 ± 0.36 Gy/GBq...Objective: 177Lu-PSMA radioligand therapy (RLT) is increasingly used to treat metastatic castration-resistant prostate cancer (mCRPC). Posttreatment dosimetry is essential for assessing normal organ absorbed doses. Therefore, this study aimsPublication Metadata only Proteomic study of in vitro osteogenic differentiation of mesenchymal stem cells in high glucose condition(2020-01-01) Kuneerat Aswamenakul; Parin Klabklai; Supitcha Pannengpetch; Tulyapruek Tawonsawatruk; Chartchalerm Isarankura-Na-Ayudhya; Sittiruk Roytrakul; Chanin Nantasenamat; Aungkura Supokawej; Faculty of Medicine, Ramathibodi Hospital, Mahidol University; Mahidol University; Thailand National Center for Genetic Engineering and Biotechnologyreduced cell viability and increased number of β-galactosidase-positive cells. Furthermore, in vitro osteogenesis was shown to be reduced in MSCs cultured in osteogenic differentiation medium at 10, 25, and 40 mM glucose as demonstrated by Alizarin red... S staining and alkaline phosphatase activity assay. Moreover, a proteomic study was performed in MSCs cultured with 25 and 40 mM glucose. The proteomic results demonstrated that 12 proteins were up- and downregulated in bone marrow-derived mesenchymal stemItem Metadata only Eltrombopag in combination with immunosuppressive therapy in pediatric severe aplastic anemia: phase 2 ESCALATE trial(2025-08-12) Shimamura A.; Maschan A.; Bennett C.; Samarasinghe S.; Farrar J.E.; Li C.K.; Sirachainan N.; Pongtanakul B.; Komvilaisak P.; Zubarovskaya L.; Rothman J.A.; Walkovich K.; Nakano T.A.; Bertuch A.A.; Ferrao A.; Bhat R.; Hanna R.; Overholt K.; Boklan J.; Wong T.F.; Wang Q.; Urban P.; Strahm B.; Wang W.; Vlachos A.; Williams D.A.; Shimamura A.; Mahidol UniversitySevere aplastic anemia (SAA) is a rare, life-threatening disease with acquired pancytopenia and hypocellular bone marrow. ESCALATE evaluated eltrombopag in combination with immunosuppressive therapy (IST) in pediatric patients (aged 1 to <18 years...) with relapsed/ refractory (R/R) or treatment-naïve SAA. The eltrombopag starting dose was 25 mg/d for patients aged 1 to <6 years and 50 mg/d for patients aged 6 to <18 years; dose modifications (maximum dose, 150 mg/d) were allowed to achieve a target plateletPublication Open Access Radiotherapy as an Immunosuppressive Agent for Allotransplantation: Literature Review and Clinical Experience - Past, Present, and Future(2018) Chuleeporn Jiarpinitnun; Thiti Swangsilpa; Puangpen Tangboonduangjit; Rasin Worawongsakul; Orawan Rattanasuwan; ชุลีพร เจียรพินิจนันท์; ธิติ สว่างศิลป์; พวงเพ็ญ ตั้งบุญดวงจิตร; ราศิน วรวงศากุล; อรวรรณ รัตนสุวรรณ; Mahidol University. Faculty of Medicine Ramathibodi Hospital. Department of Radiologyradiotherapy techniques such as total marrow and/or lymphoid irradiation by volumetric arc therapy (VMAT) or helical tomotherapy (HT) have gained interests. These advanced techniques could increase therapeutic ratio by improving conformity high radiation dose...Radiotherapy could function as immunosuppressive agent for allotransplantation due to the ability of ionizing radiation to cause cell death, the technique could be applied to irradiate total body, bone marrow and/or lymphoid tissues of the recipientItem Metadata only Natural Polyphenol Corilagin Enhances Osteogenesis and Chondrogenesis Differentiation of Mesenchymal Stem Cells: Implications for Bone and Cartilage Regeneration(2026-01-01) Kulsirirat T.; Honsawek S.; Takeda-Morishita M.; Sathirakul K.; Kulsirirat T.; Mahidol Universitypharmacological properties, its potential role in regulating bone marrow mesenchymal stem cell (BM-MSC) differentiation has not been fully explored in biomedical applications. In this study, we investigated the effects of corilagin on BM-MSC viability, protein....56 to 50 µg/mL within 48 h, whereas prolonged exposure resulted in a time-dependent reduction in viability. In BM-MSCs, corilagin significantly enhanced osteogenic and chondrogenic differentiation in a dose-dependent manner, as evidenced by increasedPublication Open Access Severe falciparum malaria treated with artesunate complicated by delayed onset haemolysis and acute kidney injury(2015) Katherine Plewes; Haider, Md Shafiul; Kingston, Hugh W F; Yeo, Tsin W; Aniruddha Ghose; Hossain, Md Amir; Dondorp, Arjen M; Turner, Gareth D H; Anstey, Nicholas M; Mahidol University. Faculty of Tropical Medicine. Mahidol-Oxford Tropical Medicine Research UnitBackground: Severe falciparum malaria may be complicated by haemolysis after parasite clearance, however the mechanisms remain unclear. Recent reports describe a pattern of delayed onset haemolysis among non-immune travellers with hyperparasitaemia treated with intravenous artesunate, termed post-artesunate delayed haemolysis (PADH). The occurrence and clinical impact of PADH following severe malaria infections in areas of unstable transmission are unknown. Case: A 45-year-old Bangladeshi male was initially admitted to a local hospital with severe falciparum malaria complicated by hyperparasitaemia and treated with intravenous artesunate. Twenty days from his first presentation he was readmitted with delayed onset haemolytic anaemia and acute kidney injury. Multiple blood transfusions and haemodialysis were required. Renal biopsy revealed acute tubular injury and haem pigment nephropathy. His haemoglobin and renal function recovered to baseline after 62 days from his second admission. Discussion: This case highlights the differential diagnosis of post-malaria delayed onset haemolysis, including the recently described syndrome of post-artemisinin delayed haemolysis. The pathophysiology contributing to acute kidney injury in this patient and the limited treatment options are discussed. Conclusions: This report describes PADH complicated by acute kidney injury in an adult patient living in a malaria hypoendemic region who subsequently required blood transfusions and haemodialysis. This case emphasizes the importance of routine follow up of haemoglobin and renal function in artesunate-treated patients who have recovered from severe malaria.Publication Open Access Phenotypic alterations in human saphenous vein culture induced by tumor necrosis factor-alpha and lipoproteins: a preliminary development of an initial atherosclerotic plaque model(2013) Kriengchai Prasongsukarn; Urai Chaisri; Peenutchanee Chartburus; Kamolwan Wetchabut; Surachet Benjathummarak; Vasant Khachansaksumet; Yaowapa Maneerat; Mahidol University. Faculty of Tropical Medicine. Department of Tropical Pathology: Normal HSV segments, from male patients who had coronary bypass graft, were cultured in DMEM containing 5% heat inactivated fetal bovine serum. TNF-α (5 ng/ml) was applied in combination with native LDL (nLDL) or oxidized LDL (oxLDL) at the dose of 50 μ