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Publication Metadata only Molecularly targeted therapy in neuro-oncology(2012-01-12) Sith Sathornsumetee; Jeremy N. Rich; Mahidol University; Cleveland Clinic Foundationtumors in adults, has been center stage for development of molecularly targeted therapy in neuro-oncology. Most targeted agents explored in brain tumors are monoclonal antibodies and small-molecule kinase inhibitors. First-generation, single-targeted... to overcome resistance have been developed simultaneously. In addition to tumor cells, therapies targeting the tumor microenvironment are also critical. As GBM is highly vascular tumor, antiangiogenic therapy may represent a novel treatment approachItem Metadata only Oral Pulmonary Arterial Hypertension-Targeted Therapy in Patients With Pulmonary Hypertension due to Interstitial Lung Disease(2025-01-01) Selvan K.C.; Teerapuncharoen K.; Bag R.; Selvan K.C.; Mahidol UniversityBackground: The aim of the study was to determine whether treatment with oral pulmonary arterial hypertension (PAH)-targeted therapy is associated with functional or hemodynamic improvement in patients with pulmonary hypertension due to interstitial... of inhaled treprostinil or iloprost and prior PAH-targeted therapy initiated before consenting to registry enrollment, thus precluding baseline data. Data analyzed included demographics, interstitial lung disease (ILD) classification, PAH-targeted therapyPublication Metadata only Targeted endometrial cancer therapy as a future prospect(2013-03-01) Duangmani Thanapprapasr; Chalong Cheewakriangkrai; Puchong Likittanasombut; Kamolrat Thanapprapasr; David G. Mutch; Mahidol University; Chiang Mai University; Thailand National Metal and Materials Technology Center; Washington University in St. Louisin patients with advanced disease is poor. Hence, better therapy is needed and targeted molecular therapies are emerging as possible treatment candidates. These include molecules that target VEGF, mTOR, tyrosine kinases, human EGF receptors and FGF receptors.... Therapies targeting specific molecular features should be evaluated in future strategies in the treatment of endometrial cancer. © 2013 Future Medicine Ltd.Publication Open Access กระบวนการซ่อมแซมดีเอ็นเอกับการรักษาโรคมะเร็งยุคใหม่(2558) ดลนิภัทร เดชสุพงศ์; ธัญนันท์ เรืองเวทย์วัฒนา; Donniphat Dejsuphong; Thanyanan Reungwetwattana; มหาวิทยาลัยมหิดล. คณะแพทยศาสตร์โรงพยาบาลรามาธิบดี. สำนักงานวิจัย; มหาวิทยาลัยมหิดล. คณะแพทยศาสตร์โรงพยาบาลรามาธิบดี. ภาควิชาอายุรศาสตร์cells as a novel target for targeted cancer therapy.... repair, mutation starts to accumulate in the genome and leads to genomic instability and cancer. In this article, we will review background of DNA damage repair, DNA repair deficiency in cancer cells and mechanism of targeting DNA repair pathway in cancerItem Metadata only Cost-Utility Analysis of Genomic Profiling in Directing Targeted Therapy in Advanced NSCLC in Thailand(2025-01-01) Turongkaravee S.; Nathisuwan S.; Baisamut T.; Meanwatthana J.; Turongkaravee S.; Mahidol UniversityBackground: Sequential next-generation sequencing (NGS) testing has demonstrated cost-effectiveness in guiding targeted therapy with tyrosine kinase inhibitors (TKIs) for advanced non-small cell lung cancer (aNSCLC) in developed countries. However... with first-line targeted therapy, as implemented under Thailand's Universal Health Coverage scheme for aNSCLC. Method: Hybrid decision tree and Markov models were developed to estimate the lifetime costs and quality-adjusted life years (QALYs) associatedItem Metadata only Innovative Design of Targeted Nanoparticles: Polymer–Drug Conjugates for Enhanced Cancer Therapy(2023-09-01) Junyaprasert V.B.; Thummarati P.; Mahidol Universityrelease, and targeted delivery to tumor tissues. This review provides a comprehensive overview of recent developments in PDCs for cancer therapy. First, various types of polymers used in these conjugates are discussed, including synthetic polymers... the drug to tumor cells, reducing off-target effects and improving therapeutic outcomes. In conclusion, PDCs have emerged as a versatile and effective approach to cancer therapy. Their ability to combine the advantages of polymers and drugs offers enhancedPublication Metadata only Efficacy of Targeted Immunotherapy as Induction or Salvage Therapy in Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis(2021-01-01) Ben Ponvilawan; Pongthep Vittayawacharin; Pattaraporn Tunsing; Weerapat Owattanapanich; Siriraj Hospitalstudies were randomized, controlled trials (RCTs) or cohort studies in which ALL patients received CD-targeted immunotherapy or conventional chemotherapy as the induction or salvage therapy. The reports had to report our primary outcomes of interest... the Hantel-Maenszel method. Results: Five RCTs and 9 retrospective cohort studies were eligible for the meta-analysis. ALL patients given CD-targeted immunotherapy in the induction or salvage therapy had significantly higher OS and RFS rates than thosePublication Metadata only N-terminal-pro-brain natriuretic peptide: A guide for early targeted indomethacin therapy for patent ductus arteriosus in preterm Infants(2011-09-01) Pracha Nuntnarumit; Prapaiporn Chongkongkiat; Anant Khositseth; Mahidol UniversityAim: To determine whether N-terminal-pro-brain natriuretic peptide (NT-proBNP) level could be an effective guide for early targeted indomethacin therapy for patent ductus arteriosus (PDA) in preterm infants. Methods: An interventional study involved...PDA. Unnecessary exposure to indomethacin occurred in two infants (11%). Overall, no enrolled infants had either reopening of ductus or PDA ligation. Conclusion: Using NT-proBNP level on day 2 as a guide for early targeted indomethacin therapy reduced later onsetPublication Metadata only Centrality searching on signal transduction pathway for drug selection support system in targeted cancer therapy(2017-02-21) Massaya Samnienggam; Tanasanee Phienthrakul; Mahidol University© 2016 IEEE. Cancer is a leading cause of death in the world. Many researchers are still searching for cancer treatments as well. This paper proposes a technique to support the cancer treatments, call Targeted Cancer Therapy. This treatment affects... specific to cancer cells to inhibit signal transduction processes because the signal transduction is the cause of the growth and division of cancer cells. Normally, this treatment will take drugs to the target gene that causes cancer. However, sometimesItem Metadata only Emulsion Technology in Nuclear Medicine: Targeted Radionuclide Therapies, Radiosensitizers, and Imaging Agents(2023-01-01) Winuprasith T.; Koirala P.; McClements D.J.; Khomein P.; Mahidol Universitymethods are usually simple, economic, robust, and scalable, which makes them suitable for medical applications. In this review, we highlight the potential of emulsion technology in nuclear medicine for developing targeted radionuclide therapies, for use...Radiopharmaceuticals serve as a major part of nuclear medicine contributing to both diagnosis and treatment of several diseases, especially cancers. Currently, most radiopharmaceuticals are based on small molecules with targeting ability. However