Emulsion Technology in Nuclear Medicine: Targeted Radionuclide Therapies, Radiosensitizers, and Imaging Agents
Issued Date
2023-01-01
Resource Type
eISSN
11782013
Scopus ID
2-s2.0-85167371619
Pubmed ID
37555189
Journal Title
International journal of nanomedicine
Volume
18
Start Page
4449
End Page
4470
Rights Holder(s)
SCOPUS
Bibliographic Citation
International journal of nanomedicine Vol.18 (2023) , 4449-4470
Suggested Citation
Winuprasith T., Koirala P., McClements D.J., Khomein P. Emulsion Technology in Nuclear Medicine: Targeted Radionuclide Therapies, Radiosensitizers, and Imaging Agents. International journal of nanomedicine Vol.18 (2023) , 4449-4470. 4470. doi:10.2147/IJN.S416737 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/88348
Title
Emulsion Technology in Nuclear Medicine: Targeted Radionuclide Therapies, Radiosensitizers, and Imaging Agents
Author(s)
Other Contributor(s)
Abstract
Radiopharmaceuticals serve as a major part of nuclear medicine contributing to both diagnosis and treatment of several diseases, especially cancers. Currently, most radiopharmaceuticals are based on small molecules with targeting ability. However, some concerns over their stability or non-specific interactions leading to off-target localization are among the major challenges that need to be overcome. Emulsion technology has great potential for the fabrication of carrier systems for radiopharmaceuticals. It can be used to create particles with different compositions, structures, sizes, and surface characteristics from a wide range of generally recognized as safe (GRAS) materials, which allows their functionality to be tuned for specific applications. In particular, it is possible to carry out surface modifications to introduce targeting and stealth properties, as well as to control the particle dimensions to manipulate diffusion and penetration properties. Moreover, emulsion preparation methods are usually simple, economic, robust, and scalable, which makes them suitable for medical applications. In this review, we highlight the potential of emulsion technology in nuclear medicine for developing targeted radionuclide therapies, for use as radiosensitizers, and for application in radiotracer delivery in gamma imaging techniques.