Emulsion Technology in Nuclear Medicine: Targeted Radionuclide Therapies, Radiosensitizers, and Imaging Agents

dc.contributor.authorWinuprasith T.
dc.contributor.authorKoirala P.
dc.contributor.authorMcClements D.J.
dc.contributor.authorKhomein P.
dc.contributor.otherMahidol University
dc.date.accessioned2023-08-17T18:01:22Z
dc.date.available2023-08-17T18:01:22Z
dc.date.issued2023-01-01
dc.description.abstractRadiopharmaceuticals serve as a major part of nuclear medicine contributing to both diagnosis and treatment of several diseases, especially cancers. Currently, most radiopharmaceuticals are based on small molecules with targeting ability. However, some concerns over their stability or non-specific interactions leading to off-target localization are among the major challenges that need to be overcome. Emulsion technology has great potential for the fabrication of carrier systems for radiopharmaceuticals. It can be used to create particles with different compositions, structures, sizes, and surface characteristics from a wide range of generally recognized as safe (GRAS) materials, which allows their functionality to be tuned for specific applications. In particular, it is possible to carry out surface modifications to introduce targeting and stealth properties, as well as to control the particle dimensions to manipulate diffusion and penetration properties. Moreover, emulsion preparation methods are usually simple, economic, robust, and scalable, which makes them suitable for medical applications. In this review, we highlight the potential of emulsion technology in nuclear medicine for developing targeted radionuclide therapies, for use as radiosensitizers, and for application in radiotracer delivery in gamma imaging techniques.
dc.identifier.citationInternational journal of nanomedicine Vol.18 (2023) , 4449-4470
dc.identifier.doi10.2147/IJN.S416737
dc.identifier.eissn11782013
dc.identifier.pmid37555189
dc.identifier.scopus2-s2.0-85167371619
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/88348
dc.rights.holderSCOPUS
dc.subjectChemical Engineering
dc.titleEmulsion Technology in Nuclear Medicine: Targeted Radionuclide Therapies, Radiosensitizers, and Imaging Agents
dc.typeReview
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85167371619&origin=inward
oaire.citation.endPage4470
oaire.citation.startPage4449
oaire.citation.titleInternational journal of nanomedicine
oaire.citation.volume18
oairecerif.author.affiliationUniversity of Massachusetts Amherst
oairecerif.author.affiliationMahidol University
oairecerif.author.affiliationFaculty of Medicine, Chulalongkorn University

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