Publication: Dengue virus-specific memory t cell responses in human volunteers receiving a live attenuated dengue virus type 2 candidate vaccine
Issued Date
1994-01-01
Resource Type
ISSN
15376613
00221899
00221899
Other identifier(s)
2-s2.0-0028364079
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.170, No.1 (1994), 27-33
Suggested Citation
Tararaj Dharakul, Ichiro Kurane, Natth Bhamarapravati, Sutee Vaughn, David W. Vaughn, Charles H. Hoke, Francis A. Ennis Dengue virus-specific memory t cell responses in human volunteers receiving a live attenuated dengue virus type 2 candidate vaccine. Journal of Infectious Diseases. Vol.170, No.1 (1994), 27-33. doi:10.1093/infdis/170.1.27 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/9843
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Title
Dengue virus-specific memory t cell responses in human volunteers receiving a live attenuated dengue virus type 2 candidate vaccine
Abstract
A live attenuated dengue virus type 2 candidate vaccine (16681-PDK53) was evaluated in a phase I trial in 10 nonimmune adult volunteers. The dengue virus-specific memory T cell responses were analyzed as part of this study. Dengue virus-specific T cell proliferative responses were observed in all subjects after stimulating their peripheral blood mononuclear cells with live viruses or noninfectious viral antigens. The highest proliferative response was against dengue virus type 2, although cross-reactivity with other flaviviruses was detected to a lesser degree in some subjects. Dengue virus type 2-specific CD4 + and CD8 + cytotoxic T lymphocytes were generated in all vaccinees. This study investigated whether the candidate vaccine was efficacious in inducing dengue virus-specific CD4 + and CD8 + T cell memory after a single immunization in nonimmune recipients. © 1994 by The University of Chicago.